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Home › Conditions › Fungal infection

Fungal infection

Subtypes of Fungal infection

Coccidioidomycosis 6 Blastomycosis 3 Histoplasmosis 3 Mucormycosis 3 Invasive candidiasis 2 Valley Fever 2 Aspergillosis 1 Mucorales infection 1 Mycetoma 1 Vulvovaginal candidiasis 1

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Fungal infection

29 trials tracked for Fungal infection: 16 in phase 3 or 4 and 5 with published results. The most-cited published study has 273 citations.

29Trials tracked
16Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 4 Phase 3 12 Phase 2 4 Phase 1 6 Other / NA 3
  1. Phase 3 A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) Completed · 273 cited
  2. Phase 3 Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Completed · 108 cited
  3. Phase 3 Endemic Mycoses Treatment With SUBA-itraconazole vs Itraconazole Completed · 39 cited
  4. Phase 3 Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant Completed · 39 cited
  5. Phase 3 Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis Completed · 16 cited
  6. Phase 4 A Trial Comparing Efficacy and Safety of Voriconazole Administered With Therapeutic Drug Monitoring vs. Standard Dosing Completed
Show 23 more trials
  1. Phase 4 Itraconazole Oral Absorption Completed
  2. Phase 4 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed
  3. Phase 4 Effect of Weight and/or Obesity on Caspofungin Drug Concentrations Completed
  4. Phase 3 Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Completed
  5. Phase 3 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed
  6. Phase 3 A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults (MK-0991-066) Completed
  7. Phase 3 Posaconazole Treatment of Invasive Fungal Infection (IFI) (P05551) Completed
  8. Phase 3 Beta Glucan Assay in Patients Receiving Voriconazole Prophylaxis Completed
  9. Phase 3 Oral Posaconazole Three Times Per Day vs Weekly High Dose Amphotericin B Lipid Complex (ABLC) Completed
  10. Phase 3 A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED) Completed
  11. Phase 2 Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients Completed
  12. Phase 2 CD101 Compared to Caspofungin Followed by Oral Step Down in Subjects With Candidemia and/or Invasive Candidiasis-Bridging Extension Completed
  13. Phase 2 Pharmacokinetics of Posaconazole Prophylaxis in Acute Leukemia Completed
  14. Phase 2 Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options Completed
  15. Phase 1 Pharmacokinetics and Safety of Posaconazole Tablet in Participants at High Risk for Invasive Fungal Infections (MK-5592-065/P05615) Completed
  16. Phase 1 Pharmacokinetics and Safety of Oral Posaconazole (MK-5592)Tablets in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-117) Completed
  17. Phase 1 Anidulafungin PK in Infants and Toddlers Completed
  18. Phase 1 Pharmacokinetics and Safety of Intravenous Posaconazole (MK-5592) in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-120) Completed
  19. Phase 1 Phase I Clinical Trial for Comparison of Pharmacokinetic Characteristics of Vorico Injection 200mg(Voriconazole) and Vfend® IV 200mg for Single Dose Crossover Intravenous Infusion in Healthy Volunteers Completed
  20. Phase 1 Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension in Subjects at High Risk for Invasive Fungal Infections (P05520) Completed
  21. N/A A Russian Prospective Observational Study of Invasive Fungal Infections in Patients With Acute Leukemia and Hematopoietic Stem Cell Transplantation Completed
  22. N/A Open, Non Comparative Study Of Voriconazole In Slovak Patients With Very High Risk Of Developing An Invasive Fungal Infection Completed
  23. N/A Vfend Special Investigation For Prophylaxis Completed

Showing the 29 most-cited and recently-updated of 29 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Fungal biotransformation platform may generate new anti-infective molecules to combat antimicrobial resistance
Infectious Disease Sys. Review
Fungal biotransformation platform may generate new anti-infective molecules to combat antimicrobial resistance Fungal Biotransformation May Help Combat Antimicrobial Resistance
This narrative review discusses fungal biotransformation as a discovery platform for generating structurally refined metabolites with anti-i…
New research explores how fungal systems can transform chemicals into new molecules to help fight stubborn bacterial and fungal infections.
Frontiers Jun 10, 2026
Vitamin D's role in antifungal immunity remains uncertain due to species differences
Nutrition & Obesity Medicine Sys. Review
Vitamin D's role in antifungal immunity remains uncertain due to species differences Primate biology limits how rodent vitamin D data applies to human fungal infections
This narrative review examines the potential role of vitamin D in antifungal immunity. The authors synthesize evidence from animal models bu…
A review notes that species differences and model limitations prevent direct translation of rodent findings to human fungal disease treatmen…
Frontiers Jun 6, 2026
Laboratory study evaluates antifungal susceptibility of Aspergillus from Costa Rican coffee beans
Primary Care & Family Medicine Guideline
Laboratory study evaluates antifungal susceptibility of Aspergillus from Costa Rican coffee beans Lab study finds coffee bean fungi often resist common antifungal drugs
This laboratory study evaluated antifungal susceptibility of Aspergillus spp. isolated from coffee beans in Costa Rica. The authors report m…
Laboratory testing of fungi from Costa Rican coffee beans shows many strains resist standard antifungal medications like amphotericin B and …
Frontiers May 20, 2026
Review of antifungal options for vulvovaginal candidiasis in women of reproductive age
Infectious Disease Sys. Review
Review of antifungal options for vulvovaginal candidiasis in women of reproductive age New Treatments for a Common Yeast Infection That Keeps Coming Back
This review examines antifungal treatments for vulvovaginal candidiasis in women of reproductive age. The authors discuss azoles, boric acid…
If you have a yeast infection that won't go away with standard creams, new oral medications and even boric acid are changing how doctors tre…
Frontiers May 15, 2026
Secondary analysis of 342 sepsis patients reveals limited diagnostic utility for serum biomarkers in invasive candidiasis diagnosis
Emergency Medicine RCT
Secondary analysis of 342 sepsis patients reveals limited diagnostic utility for serum biomarkers in invasive candidiasis diagnosis Doctors tested blood markers to find infection signs in sick patients quickly
Analysis of 342 sepsis patients across German ICUs shows serum antigens rise in infection, but antibodies do not. Single biomarkers offer mo…
A study of 342 sick patients found that one specific blood test works best for spotting dangerous infections. Combining multiple tests did n…
May 13, 2026
Review of preclinical FH12-based Sandwich-ELISA for mucormycosis detection
Infectious Disease
Review of preclinical FH12-based Sandwich-ELISA for mucormycosis detection Lab test shows promise for detecting mucormycosis in humans
This preclinical review evaluates an FH12-based Sandwich-ELISA for detecting mucormycosis.
A new lab method detects a specific marker for mucormycosis without cross-reacting with other fungi, offering a potential tool for diagnosis…
medRxiv Apr 24, 2026
Clinical-immuno-inflammatory signature for Aspergillus–Mucorales co-infection in ICU patients
Infectious Disease Cohort
Clinical-immuno-inflammatory signature for Aspergillus–Mucorales co-infection in ICU patients ICU patients with co-infection show higher but not significant mortality
This single-center observational cohort study of 93 critically ill ICU patients found that a clinical-immuno-inflammatory signature for earl…
Critically ill patients with both Aspergillus and Mucorales infections had higher ICU mortality, but the difference was not statistically si…
Frontiers Apr 23, 2026
Nasopharyngeal swab tNGS shows high bacterial concordance with BALF in ICU pneumonia
Infectious Disease Cohort
Nasopharyngeal swab tNGS shows high bacterial concordance with BALF in ICU pneumonia Nasal swabs can spot key pneumonia germs in ICU patients when lung tests aren't ready
This prospective observational cohort study in 105 critically ill ICU patients found high concordance between nasopharyngeal swab (NPS) and…
For critically ill pneumonia patients, a quick nasal swab can often match the gold-standard lung test for major bacteria, offering a faster …
Frontiers Apr 22, 2026
Narrative review on essential oils versus traditional antifungal drugs for fungal infections
Drug Pipeline Sys. Review
Narrative review on essential oils versus traditional antifungal drugs for fungal infections Nature's Shield: Essential Oils Fight Fungal Resistance
This narrative review synthesizes evidence on essential oils (EOs) and their compounds compared to traditional antifungal drugs for fungal i…
Essential oils from common plants can stop fungal infections more effectively and safely than many traditional medicines.
Frontiers Apr 19, 2026
Pooled analysis review of rezafungin versus caspofungin for candidemia and invasive candidiasis
Drug Pipeline
Pooled analysis review of rezafungin versus caspofungin for candidemia and invasive candidiasis Weekly Drug Clears Blood Fungus Faster Than Daily Treatment
This review synthesizes a pooled analysis of two randomized trials evaluating rezafungin versus caspofungin in adults with candidemia or inv…
A new weekly medication clears blood infections just as well as daily shots, offering hope for shorter care.
Apr 19, 2026
Observational study in Sudan finds few immune differences in mycetoma species
Infectious Disease
Observational study in Sudan finds few immune differences in mycetoma species Grains hide a secret immune trap in mycetoma
This research article describes an observational study of 11 patients with mycetoma in Sudan, analyzing immune protein distribution and cell…
In mycetoma, a shield of immune cells forms right next to the grain, blocking healing and trapping the disease inside the body.
medRxiv Apr 16, 2026
Review synthesizes fungal immune evasion mechanisms and emerging immunotherapies for invasive fungal infections
Infectious Disease Sys. Review
Review synthesizes fungal immune evasion mechanisms and emerging immunotherapies for invasive fungal infections Review explores how fungi evade immune systems and potential new treatment approaches
A narrative review synthesizes advances in understanding immune evasion by major fungal pathogens and immune dysregulation in immunocompromi…
Fungi like Candida and Aspergillus evade the immune system by hiding or forming biofilms, but new treatments could combine antifungal drugs …
Frontiers Apr 7, 2026

Questions about Fungal infection

Does having a fungal infection mean I have a bacterial infection in my lungs?

Having a fungal infection in your lungs does not automatically mean you have a bacterial infection, though both can occur together in certain conditions like HIV or COPD.

Full answer →

All Fungal infection Articles