Research across Kidney Diseases
Related studies from across the Kidney Diseases family.
cGAS-STING signaling pathway activation drives inflammation, fibrosis, and functional decline in various kidney diseases
Immune pathway linked to kidney disease progression
This systematic review explores the role of the cGAS-STING signaling pathway in renal pathologies. The authors conclude that this pathway is…
A newly mapped immune pathway may drive kidney damage, opening doors for future treatments.
Post-translational modifications represent a critical target for precise molecular intervention in diabetic kidney disease
Protein modifications may drive diabetic kidney disease progression
This systematic review examines the role of post-translational modifications (PTMs) such as phosphorylation and acetylation in diabetic kidn…
A new review reveals how tiny protein changes fuel diabetic kidney disease, opening doors for targeted treatments.
Machine learning models show high diagnostic accuracy for predicting pediatric cardiac surgery associated acute kidney injury
Machine Learning Models Show Promise Predicting Pediatric Kidney Injury
This meta-analysis of 7 studies evaluated the diagnostic accuracy of machine learning models for predicting pediatric cardiac surgery associ…
New analysis shows machine learning models can accurately predict kidney injury in children undergoing cardiac surgery, though more testing …
Continuous renal replacement therapy may support metabolic and circulatory stability in preterm infants with AKI
CRRT Treatment Shows Promise for Infants with Kidney Injury
This case report and literature review describes the use of continuous renal replacement therapy (CRRT) for a very low birth weight preterm …
A new case report highlights how continuous renal replacement therapy may help stabilize very low birth weight infants facing acute kidney i…
Programmed cell death pathways form a spatiotemporally regulated network driving tubular damage in renal IRI
New research identifies key pathways driving acute kidney injury
This systematic review examines the roles of pyroptosis, ferroptosis, cuproptosis, and necroptosis as key mediators of inflammation and oxid…
Researchers have mapped out a complex network of cell death pathways that drive inflammation and damage in patients with acute kidney injury…
Active stone-directed intervention reduces odds of composite recurrence and surgery for asymptomatic kidney stones
Active Intervention Reduces Surgery for Patients with Kidney Stones
This meta-analysis of 592 patients found that active stone-directed intervention significantly reduced the odds of composite recurrence (OR …
Active treatment for asymptomatic kidney stones may lower the risk of future surgeries and stone growth while maintaining a similar safety p…
Ambulatory hypertension in pediatric chronic kidney disease patients increases risk of left ventricular hypertrophy
High Blood Pressure Linked to Heart Changes in Children
This meta-analysis of 51 studies involving 6509 children with chronic kidney disease found that ambulatory hypertension is associated with i…
New data shows a strong link between high blood pressure and heart muscle thickening in children with chronic kidney disease.
Roxadustat increases odds of vascular access thrombosis and all-cause mortality in patients with chronic kidney disease
Roxadustat Linked to Higher Risk of Blood Clots in Kidney Patients
This systematic review and meta-analysis of 11,418 adults with chronic kidney disease found that roxadustat is associated with higher odds o…
A review of over 11,000 patients suggests roxadustat may increase the risk of blood clots and death for those with chronic kidney disease.
Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
Cystatin C shows promise for early detection of kidney injury
This meta-analysis of 17 studies evaluates the diagnostic performance of Cystatin C for detecting acute kidney injury in patients with sepsi…
A new look at 17 studies suggests that Cystatin C could help doctors identify kidney damage in sepsis patients much earlier than current met…
Semaglutide reduces risk of kidney decline or death in type 2 diabetes and CKD
Semaglutide lowers kidney and heart risks in type 2 diabetes patients
This randomized controlled trial enrolled 3,533 participants with type 2 diabetes and chronic kidney disease. Once-weekly subcutaneous semag…
A large trial shows once-weekly semaglutide reduces kidney failure and death risks in people with type 2 diabetes and chronic kidney disease…
Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
Sepsis may damage kidneys by letting gut bacteria toxins leak into the blood
This narrative review examines the role of gut microbiota dysbiosis in sepsis-associated acute kidney injury and acute kidney injury. The au…
A review suggests that sepsis changes gut bacteria, causing harmful toxins to leak and hurt kidneys in humans and animals.
Jinlida Granule reduces serum creatinine and HbA1c in diabetic kidney disease patients across a meta-analysis
Jinlida Granule lowers key kidney markers in diabetic kidney disease patients
This systematic review and meta-analysis evaluated Jinlida Granule for diabetic kidney disease in 1,341 patients. The pooled analysis showed…
A large review of 1,341 patients found Jinlida Granule significantly lowered kidney stress markers and blood sugar levels compared to standa…