Research across Kidney Diseases
Related studies from across the Kidney Diseases family.
Gut microbiota-associated metabolites and microbial products influence renal inflammatory and fibrotic responses in diabetic kidney disease
Gut bacteria and metabolites may impact diabetic kidney disease
This narrative review examines the role of gut microbiota-associated metabolites and microbial products in diabetic kidney disease. The auth…
Changes in gut bacteria and the chemicals they produce may play a role in how diabetes affects kidney health.
Insulin resistance serves as a sentinel biomarker for progression toward multiple cardiometabolic diseases
Insulin Resistance May Signal Early Risk for Chronic Diseases
This clinical guideline review evaluates insulin resistance (IR) as a sentinel biomarker for early progression toward type 2 diabetes, heart…
Insulin resistance can act as an early warning sign for several conditions, including heart disease and type 2 diabetes, before symptoms app…
nsMRA plus SGLT2 inhibitor combination therapy reduces ACR by approximately 33% in CKD patients
Combination therapy shows better kidney protection for chronic disease
This meta-analysis of 1835 adults with CKD and albuminuria found that nsMRA plus SGLT2 inhibitor combination therapy resulted in a greater r…
Combining two specific medications may better reduce protein in the urine for people with chronic kidney disease, though it carries a higher…
Psychosocial interventions significantly reduce depressive symptoms in patients with stage 4 or 5 chronic kidney disease
Psychosocial Interventions Reduce Depression in Chronic Kidney Disease Patients
This meta-analysis of 792 patients with chronic kidney disease found that psychosocial interventions, primarily cognitive-behavioral therapy…
Psychosocial treatments like cognitive-behavioral therapy may help reduce depressive symptoms for patients living with advanced chronic kidn…
Active serum phosphorus reduction reduces all-cause mortality and dialysis risk in non-dialysis CKD patients
Lowering phosphorus levels may help patients with chronic kidney disease
This meta-analysis of randomized controlled trials involving 3149 patients found that actively reducing serum phosphorus significantly reduc…
Lowering phosphorus levels in the blood may reduce the risk of death and delay the need for dialysis for people with chronic kidney disease.
Endothelin receptor antagonists reduce albuminuria and kidney events in patients with diabetic kidney disease
Endothelin Receptor Antagonists May Help Protect Kidneys in Diabetes
This narrative review explores the role of the ET-1/ETAR axis in the progression of diabetic kidney disease (DKD) and the therapeutic potent…
New research explores how specific medications might slow kidney damage for people living with type 2 diabetes and kidney disease.
CKD-MBD care should shift from biochemical targets to phenotype-informed, outcome-oriented management
New approach to managing bone and vascular health in kidney disease
This narrative review argues that chronic kidney disease-mineral and bone disorder (CKD-MBD) management should move beyond biochemical targe…
Doctors are pushing for a new way to treat bone and blood vessel issues in patients with chronic kidney disease.
Kidney and brain share common pathways linking renal dysfunction to neurological impairment
Kidney and Brain Health Share Linked Biological Pathways
This narrative review explores the bidirectional relationship between renal and neurological health. It details how shared vascular, metabol…
Research shows that kidney and brain health are linked through shared metabolic and immune pathways, affecting how patients recover from inj…
H. pylori eradication linked to lower proteinuria and reduced CKD risk in meta-analysis
Treating a common stomach bacteria may help manage kidney disease
This meta-analysis examines the association between Helicobacter pylori eradication and kidney outcomes in patients with kidney disease or p…
Treating a common stomach infection called H. pylori may lower protein levels in the urine and reduce the risk of chronic kidney disease.
Intermittent Hemodialysis Falls Short of Continuous Therapy in Critically Ill AKI Trial
Trial shows continuous renal-replacement therapy may reduce kidney injury mortality
In critically ill adults with acute kidney injury, intermittent hemodialysis did not prove noninferior to continuous therapy and was linked …
A trial of 554 critically ill adults found that continuous renal-replacement therapy was associated with lower mortality rates than intermit…
nsMRAs reduce UACR and systolic BP in patients with diabetic kidney disease
New medication class shows promise for diabetic kidney disease
This meta-analysis of 15,143 patients found that nsMRAs reduced log-transformed UACR by 0.36 mg/g and systolic BP by 4.72 mmHg in patients w…
A new class of drugs may lower blood pressure and protein in the urine for people with diabetic kidney disease, though some risks exist.
Metabolic profiles and specific metabolites serve as potential biomarkers for diabetic kidney disease progression
Metabolites May Help Identify New Pathways in Diabetic Kidney Disease
This systematic review synthesizes the roles of metabolites as signaling hubs and substrates for epigenetic modifications in diabetic kidney…
New research identifies how specific metabolites act as signaling hubs that could help doctors better predict and treat diabetic kidney dise…