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Lymphedema

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Lymphedema

21 trials tracked for Lymphedema: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 130 citations.

21Trials tracked

3Phase 3 & 4

0Recruiting

1With published results

Phase distribution

Phase 4 3 Phase 2 3 Other / NA 15

Phase 4 Lymphedema Study for Arm or Leg Lymphedema Completed · 130 cited
Phase 4 Effect of Exercise on Indocyanine Green (ICG) Lymphography Imaging Completed
Phase 4 Low Level Laser Treatment and Breast Cancer Related Lymphedema Completed
Phase 2 A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer Completed
Phase 2 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Completed
Phase 2 Ubenimex in Adult Patients With Lymphedema of The Lower Limb (ULTRA) Completed

Show 15 more trials

N/A A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema Completed
N/A Assessment of 3M Oedema Reduction System in the Treatment of Lymphoedema Compared to Commercial Short-stretch Bandage Completed
N/A Using Traditional Acupuncture in the Management of Cancer Treatment Related Lymphoedema Completed
N/A Lymphedema Prophylaxis in Breast Cancer Survivors Who Show Early Evidence of High-risk Status Completed
N/A Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema Completed
N/A LLLT Combined With CDT in Breast Cancer-Related Lymphedema Completed
N/A Low-Level Laser in Head and Neck Chronic Lymphedema Completed
N/A Intraoperative Evaluation of Axillary Lymphatics Completed
N/A Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema Completed
N/A Prospective Evaluation of a Surgical Solution for Breast Cancer-Associated Lymphedema Completed
N/A Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Completed
N/A Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL Completed
N/A Low-Level Laser in Treatment of Head and Neck Lymphedema: A Pilot Study Completed
N/A Self-Care for Head and Neck Cancer Survivors With Lymphedema and Fibrosis Completed
N/A Study of Prone Accelerated Breast And Nodal IMRT Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Lymphedema: what the trials found

Clinical evidence for lymphedema management includes the use of low-level laser therapy and combination therapies. Low-level laser treatment was associated with a reduction in symptom burden scores related to soft tissues and neurologic toxicity (9, 14). Additionally, combining laser therapy with manual lymphatic drainage (MLD) is an established approach (5).

Diagnostic imaging and pharmacological interventions have also been evaluated. Indocyanine green was utilized for fluorescence signal assessment (10), while Ketoprofen demonstrated a significant change from baseline in cutaneous histological architecture (p<0.0001), though it did not significantly impact skin thickness measurements (3).

Recent results — preliminary, needs further review

Advanced Pneumatic Compression Device (APCD) is currently being evaluated (1).
The Dayspring Active Wearable Compression System showed a LYMQOL of 0.83, with all 24 patients using the device for at least 45 minutes daily (2).

For the clinician treating this condition

Low-level laser therapy is an established intervention that may reduce soft tissue and neurologic toxicity symptoms.
Combining laser treatment with manual lymphatic drainage (MLD) is a recognized multimodal approach for lymphedema management.
Ketoprofen has been shown to improve cutaneous histological architecture, though its effect on skin thickness is not statistically significant.

AI synthesis of 0 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.