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Home › Conditions › Lymphedema

Lymphedema

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Lymphedema

21 trials tracked for Lymphedema: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 134 citations.

21Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 2 3 Other / NA 15
  1. Phase 4 Lymphedema Study for Arm or Leg Lymphedema Completed · 134 cited
  2. Phase 4 Effect of Exercise on Indocyanine Green (ICG) Lymphography Imaging Completed
  3. Phase 4 Low Level Laser Treatment and Breast Cancer Related Lymphedema Completed
  4. Phase 2 A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer Completed
  5. Phase 2 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Completed
  6. Phase 2 Ubenimex in Adult Patients With Lymphedema of The Lower Limb (ULTRA) Completed
Show 15 more trials
  1. N/A A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema Completed
  2. N/A Assessment of 3M Oedema Reduction System in the Treatment of Lymphoedema Compared to Commercial Short-stretch Bandage Completed
  3. N/A Using Traditional Acupuncture in the Management of Cancer Treatment Related Lymphoedema Completed
  4. N/A Lymphedema Prophylaxis in Breast Cancer Survivors Who Show Early Evidence of High-risk Status Completed
  5. N/A Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema Completed
  6. N/A LLLT Combined With CDT in Breast Cancer-Related Lymphedema Completed
  7. N/A Low-Level Laser in Head and Neck Chronic Lymphedema Completed
  8. N/A Intraoperative Evaluation of Axillary Lymphatics Completed
  9. N/A Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema Completed
  10. N/A Prospective Evaluation of a Surgical Solution for Breast Cancer-Associated Lymphedema Completed
  11. N/A Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Completed
  12. N/A Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL Completed
  13. N/A Low-Level Laser in Treatment of Head and Neck Lymphedema: A Pilot Study Completed
  14. N/A Self-Care for Head and Neck Cancer Survivors With Lymphedema and Fibrosis Completed
  15. N/A Study of Prone Accelerated Breast And Nodal IMRT Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Lymphedema: what the trials found

Clinical evidence for lymphedema management includes the use of low-level laser therapy and combination therapies. Low-level laser treatment was associated with a reduction in symptom burden scores related to soft tissues and neurologic toxicity (9, 14). Additionally, combining laser therapy with manual lymphatic drainage (MLD) is an established approach (5).

Diagnostic imaging and pharmacological interventions have also been evaluated. Indocyanine green was utilized for fluorescence signal assessment (10), while Ketoprofen demonstrated a significant change from baseline in cutaneous histological architecture (p<0.0001), though it did not significantly impact skin thickness measurements (3).

Recent results — preliminary, needs further review

  • Advanced Pneumatic Compression Device (APCD) is currently being evaluated (1).
  • The Dayspring Active Wearable Compression System showed a LYMQOL of 0.83, with all 24 patients using the device for at least 45 minutes daily (2).

For the clinician treating this condition

  • Low-level laser therapy is an established intervention that may reduce soft tissue and neurologic toxicity symptoms.
  • Combining laser treatment with manual lymphatic drainage (MLD) is a recognized multimodal approach for lymphedema management.
  • Ketoprofen has been shown to improve cutaneous histological architecture, though its effect on skin thickness is not statistically significant.

AI synthesis of 0 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Axillary lymph node dissection increases risk of arm swelling and lymphoedema in breast cancer patients
OB/GYN & Women's Health RCT
Axillary lymph node dissection increases risk of arm swelling and lymphoedema in breast cancer patients Trial Shows Axillary Surgery Predicts Long Term Arm Swelling
This randomized controlled trial of 469 patients undergoing surgery and radiotherapy for node-positive breast cancer found that axillary lym…
New research shows that axillary lymph node dissection is a primary predictor of long-term arm swelling for patients after breast cancer tre…
Jul 24, 2026
Lymphovenous anastomosis improves quality of life in breast cancer-related lymphedema
OB/GYN & Women's Health Meta-analysis
Lymphovenous anastomosis improves quality of life in breast cancer-related lymphedema Lymphedema surgery improves quality of life in breast cancer survivors
This meta-analysis of observational studies found that therapeutic lymphovenous anastomosis (LVA) significantly improves quality of life in …
A new analysis finds that lymphovenous anastomosis significantly boosts quality of life for breast cancer survivors with lymphedema, especia…
Jun 1, 2026
Protocol for randomized controlled trial of TEAS pretreatment for breast cancer-related lymphedema
Oncology RCT
Protocol for randomized controlled trial of TEAS pretreatment for breast cancer-related lymphedema New electrical therapy may stop breast cancer swelling before surgery starts
This document outlines a randomized controlled trial protocol evaluating transcutaneous electrical acupoint stimulation pretreatment in brea…
A new electrical therapy might stop arm swelling before breast cancer surgery begins
Frontiers Apr 29, 2026
Network meta-analysis suggests surgical techniques may reduce breast cancer-related lymphedema
OB/GYN & Women's Health Meta-analysis
Network meta-analysis suggests surgical techniques may reduce breast cancer-related lymphedema Surgical techniques may help prevent and treat breast cancer-related arm swelling
A network meta-analysis of breast cancer survivors found axillary reverse mapping and lymphovascular anastomoses were associated with reduce…
Specific surgeries significantly reduce breast cancer arm swelling before it starts and help shrink swollen arms after treatment while impro…
Apr 7, 2026

Questions about Lymphedema

Is lymphvenous anastomosis an effective treatment for breast cancer-related Lymphedema?

Lymphovenous anastomosis (LVA) is an effective treatment for established breast cancer-related lymphedema, showing consistent improvements in patient quality of life and physical function.

Full answer →
Do surgical techniques like axillary reverse mapping reduce the risk of Lymphedema?

Axillary reverse mapping is a surgical technique that shows significant promise in reducing the risk of breast cancer-related lymphedema.

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Does axillary lymph node dissection increase the risk of Lymphedema?

Yes, axillary lymph node dissection significantly increases the risk of lymphedema, with studies showing it is a strong predictor of arm swelling.

Full answer →