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Home › Conditions › Methamphetamine Use Disorder

Methamphetamine Use Disorder

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Methamphetamine Use Disorder

6 trials tracked for Methamphetamine Use Disorder: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 14 citations.

6Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 2 Phase 1 1 Other / NA 2
  1. Phase 3 Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT-2) for Methamphetamine Use Disorder Completed · 14 cited
  2. Phase 2 Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM Completed
  3. Phase 2 Accelerated Development of Additive Pharmacotherapy Treatment for Methamphetamine Use Disorder Completed
  4. Phase 1 Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine] Completed
  5. N/A Bupropion in the Treatment of Methamphetamine Dependence Completed
  6. N/A rTMS for Stimulant Use Disorders Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Methamphetamine Use Disorder: what the trials found

Naltrexone (Vivitrol®) has been evaluated in a Phase 3 trial for Methamphetamine Use Disorder. The study assessed Treatment Effectiveness Scores across two stages, reporting scores of 5.72 and 13.84 at Stage 1, and 7.45 and 11.55 at Stage 2 1.

In the same Phase 3 trial, the percentage of participants who used methamphetamine in the pre-evaluation period was reported across multiple cohorts as 5.10%, 11.93%, 7.95%, 10.20%, 29.46%, and 22.56% 1.

Recent results — preliminary, needs further review

  • Naltrexone Hydrochloride was evaluated in a Phase 2 trial (N=60) 2.
  • Naltrexone plus bupropion was evaluated in a Phase 2 trial (N=49) 3.
  • rTMS was evaluated in a study where 29%, 40%, 37%, and 23% of participants received at least 20 sessions over the treatment period 5.
  • bupropion SR was evaluated in a trial (N=40) 6.

For the clinician treating this condition

  • Naltrexone (Vivitrol®) has been studied in Phase 3 trials to assess treatment effectiveness and methamphetamine use rates in patients with Methamphetamine Use Disorder 1.
  • Data from established evidence indicates specific variations in both Treatment Effectiveness Scores and the percentage of patients reporting methamphetamine use during pre-evaluation periods when using Naltrexone 1.

AI synthesis of 5 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Mirtazapine reduces methamphetamine use in phase 3 trial
Drug Pipeline RCT
Mirtazapine reduces methamphetamine use in phase 3 trial Mirtazapine cuts meth use days more than placebo in adults with severe addiction
In a phase 3 RCT, mirtazapine 30 mg daily for 12 weeks led to a greater reduction in methamphetamine use days compared to placebo, with a me…
Adults with severe methamphetamine use disorder took less meth when on mirtazapine compared to placebo, with fewer days of use over 12 weeks…
Jun 7, 2026
Network meta-analysis of exercise, TMS, and behavioral therapies for methamphetamine use disorder craving
Physical Medicine & Rehab Meta-analysis
Network meta-analysis of exercise, TMS, and behavioral therapies for methamphetamine use disorder craving Exercise and brain stimulation cut meth cravings without drugs
This network meta-analysis evaluated exercise, transcranial magnetic stimulation (TMS), transcranial direct current stimulation, behavioral …
Exercise and brain stimulation reduce cravings better than standard care for people with methamphetamine use disorder.
Apr 27, 2026
Yoga with mindfulness improves sleep, anxiety, and physical function in methamphetamine addicts
Primary Care & Family Medicine RCT
Yoga with mindfulness improves sleep, anxiety, and physical function in methamphetamine addicts Yoga Class Helped People Fight Meth Addiction for 24 Weeks
A 24-week randomized controlled trial in 80 methamphetamine addicts found that a yoga intervention with mindfulness components improved slee…
A 24-week yoga program cut anxiety and sharply improved sleep in meth users, offering a quiet tool to help adults in recovery manage stress …
Frontiers Apr 16, 2026
High-frequency rTMS plus exercise reduced craving and negative emotions in methamphetamine use disorder
Physical Medicine & Rehab RCT
High-frequency rTMS plus exercise reduced craving and negative emotions in methamphetamine use disorder Magnetic Pulses Plus Exercise Lift Mood in Meth Recovery
A randomized trial in 54 male patients with methamphetamine use disorder found that adding high-frequency rTMS to physical exercise reduced …
Pairing gentle magnetic brain pulses with regular exercise helped people in recovery feel better and want meth less.
Apr 13, 2026

Questions about Methamphetamine Use Disorder

How does adding rTMS to exercise affect negative emotions in methamphetamine use disorder?

Adding high-frequency rTMS to exercise significantly reduces negative emotions like depression and anxiety in people with methamphetamine use disorder compared to exercise alone.

Full answer →
Which therapies are best for treating methamphetamine use disorder craving?

Exercise and transcranial magnetic stimulation (TMS) are the most effective non-drug therapies for reducing methamphetamine cravings, while behavioral therapies like cognitive behavioral therapy also show strong results.

Full answer →
Does adding high-frequency rTMS and exercise reduce negative emotions in methamphetamine use disorder?

Yes, a 2024 trial found that adding high-frequency rTMS to exercise significantly reduced depression, anxiety, and craving in methamphetamine use disorder compared to exercise alone.

Full answer →