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Home › Conditions › Moral Injury

Moral Injury

Part of Post-Traumatic Stress Disorder

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Moral Injury

6 trials tracked for Moral Injury: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 36 citations.

6Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Other / NA 5
  1. Phase 3 Frontline Clinician Psilocybin Study Completed · 36 cited
  2. N/A Thriving in the Midst of Moral Pain: The Acceptability and Feasibility of Acceptance and Commitment Therapy for Moral Injury (ACT-MI) Among Warzone Veterans Completed
  3. N/A Psychosocial Rehabilitation After Moral Injury and Loss With Adaptive Disclosure Completed
  4. N/A Pilot Study Testing a Web-Based Moral Elevation Intervention for Veterans With PTSD and Moral Injury Completed
  5. N/A Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD Completed
  6. N/A A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Moral Injury: what the trials found

Psilocybin (Usona Institute) is being investigated in a Phase 3 trial for moral injury 1. No outcome results are available yet.

Acceptance and Commitment Therapy for Moral Injury (ACT-MI) has been studied in a recent trial 2.

Impact of Killing (IOK) showed no significant difference in quality of life (WHOQOL-BREF, p=0.975) or PTSD symptoms (CAPS-5, p=0.831) compared to control 3.

Recent results — preliminary, needs further review

  • Adaptive Disclosure for Moral Injury and Loss showed a significant improvement in functional impairment (SDS, p=0.03) but not in psychosocial functioning (B-IPF, p=0.35) 4.
  • Mindful Self-Compassion reduced alcohol use days from baseline at post-treatment (-24.30 days) and 1-month follow-up (-26.20 days) in a small trial 5.
  • Moral Elevation intervention is being studied 6.

For the clinician treating this condition

  • Psilocybin is under Phase 3 investigation; no efficacy data available yet 1.
  • Impact of Killing (IOK) did not improve quality of life or PTSD symptoms 3.
  • Adaptive Disclosure may improve functional impairment but not psychosocial functioning 4.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Self-transcendence via mindfulness practices may serve as a mechanism for moral injury recovery
Psychiatry Sys. Review
Self-transcendence via mindfulness practices may serve as a mechanism for moral injury recovery Self-Transcendence May Help Heal Moral Injury
This integrative review explores the role of self-transcendence (ST) in addressing moral injury. The authors synthesize how mindfulness and …
A new review suggests that cultivating self-transcendence through mindfulness could help people recover from moral injury.
Frontiers Jun 10, 2026
Scoping review identifies operational and organizational drivers of burnout in public safety personnel
Psychiatry Sys. Review
Scoping review identifies operational and organizational drivers of burnout in public safety personnel Why do we know so little about moral injury in first responders?
A scoping review of 43 studies examined burnout and moral injury drivers in public safety personnel (EMTs, firefighters, dispatchers).
While burnout gets studied, moral injury in first responders is almost ignored, leaving a critical gap in how we help EMTs and firefighters.
Frontiers Apr 3, 2026