Research across Leukemia
Related studies from across the Leukemia family.
Early genetic diagnosis of inherited bone marrow failure syndromes facilitates timely transplant and lifelong surveillance
Genetic Factors May Influence Diagnosis of Bone Marrow Failure
This narrative review explores the pathogenesis, clinical manifestations, and management of pediatric patients with inherited bone marrow fa…
Genetic factors can be the hidden cause of bone marrow failure in children, making early genetic testing vital for proper treatment and plan…
Positive LSC status is associated with inferior survival outcomes in patients with acute myeloid leukemia
Leukemia Stem Cell Counts Help Doctors Predict Patient Survival Outcomes
This systematic review and reconstructed individual patient data meta-analysis analyzed survival outcomes in patients with acute myeloid leu…
Testing for specific leukemia stem cells can help doctors predict how well a patient will do during treatment.
Icotinib treatment for EGFR-mutated NSCLC may be associated with rare treatment-related myeloid neoplasm
Icotinib Treatment for Lung Cancer Linked to Rare Blood Condition
This case report and literature review describes a 75-year-old female with lung adenocarcinoma treated with icotinib. The report identifies …
A rare case of acute myeloid leukemia was linked to a specific lung cancer treatment, highlighting the need for regular blood monitoring.
Low-dose chemotherapy shows no difference in remission but worse outcomes in KIT-mutated AML
Low-dose chemotherapy shows similar results for some children with leukemia
This retrospective secondary analysis of a multicenter randomized controlled trial evaluated low-dose chemotherapy (LDC) versus standard-dos…
A study of children with a specific type of leukemia found that lower doses of chemotherapy can be as effective as standard doses for many p…
Busulfan-based conditioning favors survival in AML while TBI yields better outcomes in ALL
Busulfan Shows Survival Benefits for Patients with Acute Myeloid Leukemia
This meta-analysis of 26 studies compared Busulfan-based conditioning to total body irradiation for children and young adults undergoing hem…
Busulfan may offer better survival for certain leukemias while reducing long-term side effects like growth issues and cataracts in young pat…
MRG mutations correlate with worse overall survival and lower remission in NPM1-mutated AML
Specific gene mutations linked to worse outcomes in certain leukemia
This meta-analysis of 4,363 patients found that MRG mutations (such as ASXL1, BCOR, and EZH2) are associated with inferior overall survival …
New data shows that specific gene mutations can predict poorer survival and lower remission rates for patients with a specific type of leuke…
Treosulfan-fludarabine improves 24-month event-free survival to 65% versus 53% in AML patients
Treosulfan Shows Better Outcomes for Patients with Acute Myeloid Leukemia
This Phase 3 randomized trial subgroup analysis of 352 patients with AML undergoing alloHCT found treosulfan-fludarabine superior to reduced…
A new analysis of a Phase 3 trial suggests treosulfan may offer better survival rates and fewer complications for patients with acute myeloi…
Dasatinib 50 mg maintains efficacy while reducing pleural effusion and thrombocytopenia in CP-CML
Lower Dasatinib Dose May Improve Tolerability for Leukemia Patients
This meta-analysis of 7 nonoverlapping reports compared dasatinib 50 mg and 100 mg in adults with chronic-phase chronic myeloid leukemia. Th…
A lower daily dose of dasatinib may offer similar effectiveness with fewer side effects for adults with chronic-phase chronic myeloid leukem…
6-month IS value predicts MR4.5 attainment and TKI discontinuation eligibility in CML patients
Trial Shows Early Markers Predict Success in Chronic Myeloid Leukemia
This observational study of 431 patients with chronic myeloid leukemia (CML) on second-generation TKIs found that the 6-month IS value is a …
New data from a Phase 3 trial shows that early markers can help predict which patients with chronic myeloid leukemia may reach specific trea…
Leukapheresis not clearly linked to lower 30-day mortality in AML with hyperleukocytosis
Leukapheresis Shows No Clear Early Death Benefit in AML
This meta-analysis of 1406 adults with AML and hyperleukocytosis found that leukapheresis was not clearly associated with lower 30-day morta…
A review of 1406 AML patients found leukapheresis did not clearly lower 30-day death risk. Evidence is weak.
AML infiltration of bile duct identified as primary cause of acute pancreatitis in case report
Leukemia Cells Found as Cause of Severe Pancreatitis
This case report and literature review describes a 34-year-old man with acute pancreatitis and type 2 diabetes, where acute myeloid leukemia…
A rare case shows how a specific type of leukemia can infiltrate the pancreas and cause severe inflammation in patients with diabetes.
TKI plus chemotherapy achieves deep molecular remission in Ph+ leukemia case with diagnostic framework
One patient's leukemia remission offers clues for rare diagnosis
This systematic review with a case report describes a patient with Philadelphia chromosome-positive leukemia who achieved complete remission…
A patient with a rare leukemia achieved deep remission for 35 months. The case highlights how to tell apart two similar-looking blood cancer…