1 published article · Updated continuously
7 trials tracked for Nail psoriasis: 6 in phase 3 or 4 and 1 with published results. The most-cited published study has 37 citations.
Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →
Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.
Systemic treatments have demonstrated significant improvements in nail psoriasis severity. Etanercept resulted in a substantial reduction in both target fingernail NAPSI scores (-4.32, -4.36) and overall NAPSI scores (-22.64, -22.63) (p<0.0001), with over 80% of participants achieving at least a 50% improvement in target fingernail NAPSI by week 24 (p<0.001) 3.
Adalimumab showed significant efficacy compared to placebo, with a -56.2% change from baseline in total fingernail NAPSI scores at week 26 (p<0.001). Furthermore, 46.6% of patients achieved an mNAPSI 75 response and 48.9% achieved a 'clear' or 'minimal' physician global assessment of fingernails 5.
Topical and botanical interventions have also been evaluated. Enstilar Foam showed a modified mNAPSI score of 18 at week 24 1. Indigo Naturalis Extract in Oil demonstrated improvements in shNAPSI scores ranging from 14.4 to 27.4 over 24 weeks [4, 6].
AI synthesis of 3 cited trials, updated Jul 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.
