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Neurogenic Bladder

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Neurogenic Bladder

16 trials tracked for Neurogenic Bladder: 7 in phase 3 or 4 and 2 with published results. The most-cited published study has 387 citations.

16Trials tracked
7Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 5 Phase 2 3 Other / NA 6
  1. Phase 3 Vaginal Estriol in Multiple Sclerosis Completed · 387 cited
  2. Phase 3 Safety and Efficacy Study of OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Neurogenic Detrusor Overactivity (NDO) in Non-Catheterizing Patients With Multiple Sclerosis (MS) Completed · 25 cited
  3. Phase 4 Safety and Efficacy of botulinumA Toxin (BotoxA) for Treatment of Neurogenic Bladder of Parkinson's Disease Completed
  4. Phase 4 Safety and Efficacy Evaluation of Oxybutynin Topical Gel In Children With Neurogenic Bladder Completed
  5. Phase 3 Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury Completed
  6. Phase 3 Study to Evaluate the Efficacy and Safety of Tamsulosin in Children With Neurogenic Bladder Completed
Show 10 more trials
  1. Phase 3 Alfuzosin Treatment in Children and Adolescents With Hydronephrosis of Neuropathic Etiology Completed
  2. Phase 2 Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections Completed
  3. Phase 2 PK/PD, Long-term Safety and Efficacy of Tamsulosin Treatment in Children With Neurogenic Bladder Completed
  4. Phase 2 Multifaceted Treatment of Catheter-related Urinary Tract Infection Completed
  5. N/A The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury Completed
  6. N/A Reducing Anticholinergic Bladder Medication Use in Spinal Cord Injury With Home Neuromodulation Completed
  7. N/A A Biochip for Rapid Diagnosis of Complicated Urinary Tract Infection Completed
  8. N/A Central Nervous System Changes Following OnabotulinumtoxinA Injection in the Bladder Completed
  9. N/A Brain Targets in Patients With Bladder Emptying Difficulties Completed
  10. N/A Optimization of OnabotulinumtoxinA (BTX-A) Injection for the Treatment of Neurogenic Lower Urinary Tract Dysfunction Completed

Showing the 16 most-cited and recently-updated of 16 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Neurogenic Bladder: what the trials found

Cystoscopic injection of Botox into the urinary bladder significantly reduced the number of incontinence episodes per day (p=0.0087) 2. OnabotulinumtoxinA was also associated with changes in Incontinence Quality of Life Instrument (I-QOL) total summary scores 4.

Vaginal estriol administration resulted in a significant improvement in the Bladder Control Scale (BLCS) (p=0.002) and an increase in physical score on the MS Quality of Life Questionnaire 3. Gentamicin Sulfate was associated with a significant reduction in the number of urinary tract infections over time (p=<0.0001) 5, while its use also showed a trend toward improvement in Neurogenic Bladder Symptom Severity (NBSS) scores (p=<0.06) 5.

Tamsulosin hydrochloride was evaluated for detrusor leak point pressure (LPP); however, results were not statistically significant regarding the percentage of responders or the change from baseline in LPP at week 14 [6, 9]. Alfuzosin was associated with a decrease in the Society of Fetal Urology (SFU) Grade of Hydronephrosis in some participants 7.

Oxybutynin resulted in a statistically significant reduction in the average volume of urine collected per catheterization at week 6 (p=0.0054), though it did not significantly change the percentage of catheterizations without a leaking accident or the volume of urine collected during first morning awakening 1.

Recent results — preliminary, needs further review

  • Intra-detrusor injection of Onabotulinumtoxin-A was associated with significant changes in Blood Oxygen Level Dependent (BOLD) signals in the brain (p=0.0012) 11.
  • Transcranial Rotating Permanent Magnet Stimulator (TRPMS) showed statistically significant changes in brain activity measured via functional MRI (p=<0.05), and a significant change in %Post-Void Residual/Bladder Capacity (PVR/BC) 14.

For the clinician treating this condition

  • Botox injections into the bladder are established to reduce daily incontinence episodes 2.
  • Vaginal estriol is associated with improved bladder control scores and physical quality of life 3.
  • Gentamicin Sulfate significantly reduces the frequency of urinary tract infections in this population 5.
  • Oxybutynin can effectively reduce the average volume of urine collected per catheterization 1.

AI synthesis of 8 cited trials, updated Jul 10, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.