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Neurogenic orthostatic hypotension

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for neurogenic orthostatic hypotension

5 trials tracked for neurogenic orthostatic hypotension: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 50 citations.

5Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 2 2
  1. Phase 4 Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study Completed · 50 cited
  2. Phase 3 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed
  3. Phase 3 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) Completed
  4. Phase 2 TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) Completed
  5. Phase 2 Norepinephrine Transporter Blockade, Autonomic Failure (NETAF) Completed

Showing the 5 most-cited and recently-updated of 5 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Neurogenic orthostatic hypotension: what the trials found

Midodrine has been shown to result in a reduction of the Depression Score (Beck Depression Inventory-II) by values ranging from -3.5 to -7.8 1.

Droxidopa was evaluated for its impact on orthostatic hypotension symptoms; however, it did not produce statistically significant improvements in OHQ composite scores (p=0.438), OHDAS scores (p=0.554), or OHSA composite scores (p=0.198) 2. Droxidopa was also evaluated in a larger cohort of 350 patients 3.

Recent results — preliminary, needs further review

  • TD-9855 showed a change from baseline in Likert Scale Score at week 4 of -2.4, with various changes observed across different time points and OHSA scores (not yet corroborated) 4.
  • Atomoxetine was evaluated for its effect on the OHQ Composite Score, showing varied results ranging from 3.35 to 4.61 and -0.58 to -0.5 (not yet corroborated) 5.

For the clinician treating this condition

  • Midodrine is associated with a decrease in Beck Depression Inventory-II scores in patients with neurogenic orthostatic hypotension 1.
  • Droxidopa did not demonstrate statistically significant improvements across multiple orthostatic hypotension assessment scales (OHQ, OHDAS, and OHSA) 2.

AI synthesis of 5 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.