Research across Sepsis
Related studies from across the Sepsis family.
Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
Cystatin C shows promise for early detection of kidney injury
This meta-analysis of 17 studies evaluates the diagnostic performance of Cystatin C for detecting acute kidney injury in patients with sepsi…
A new look at 17 studies suggests that Cystatin C could help doctors identify kidney damage in sepsis patients much earlier than current met…
Sepsis Mortality Prediction Models Show Moderate Performance
Prediction models show moderate success in forecasting sepsis deaths
A meta-analysis of 84 studies finds that externally validated models for sepsis mortality achieve a pooled AUC of 0.794, but most studies ha…
New data from millions of records helps identify which factors most accurately predict if a patient with sepsis will survive.
Prediction models show moderate discrimination for ARDS occurrence and mortality in sepsis patients
Machine Learning Models Show Mixed Results for Predicting Sepsis Lung Injury
This systematic review and meta-analysis evaluated prediction models for ARDS occurrence and short-term mortality in patients with sepsis-as…
New analysis shows that while machine learning can predict lung injury in sepsis patients, these models do not consistently outperform stand…
Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
Sepsis may damage kidneys by letting gut bacteria toxins leak into the blood
This narrative review examines the role of gut microbiota dysbiosis in sepsis-associated acute kidney injury and acute kidney injury. The au…
A review suggests that sepsis changes gut bacteria, causing harmful toxins to leak and hurt kidneys in humans and animals.
Modulation of neutrophil function and death in critically ill patients with sepsis is discussed in this narrative review
Review discusses neutrophil modulation in sepsis for critically ill patients
This narrative review discusses modulation of neutrophil function and death in critically ill patients with sepsis. The authors synthesize c…
This narrative review explores how changing neutrophil function might affect sepsis outcomes in critically ill patients, though no specific …
Source control and antibiotic stewardship remain cornerstones of sepsis management
Review prioritizes antibiotic stewardship over live probiotics for sepsis
This narrative review synthesizes current evidence on sepsis management, emphasizing source control and antibiotic stewardship as key pillar…
A narrative review suggests avoiding live probiotics in high-risk sepsis patients while prioritizing antibiotic stewardship and source contr…
Antibiotic stewardship bundle aims to cut antibiotic use in Chinese NICUs
A new plan aims to cut unnecessary antibiotics for sick newborns in China
This protocol describes a multicenter, before-and-after, interrupted time series quality improvement study testing a bundled antimicrobial s…
This ongoing project in China seeks to reduce antibiotic use for newborns with sepsis while keeping them safe during treatment.
Interleukin-7 therapy improves lymphocyte counts in sepsis and COVID-19 patients
Recombinant human interleukin-7 boosts white blood cells but does not save lives in sepsis or COVID-19
A meta-analysis shows recombinant IL-7 boosts lymphocytes in sepsis and COVID-19, but only reduces secondary infections in COVID-19.
A new analysis shows this drug raises low white blood cell counts in sepsis and COVID-19 but does not lower death risk or improve survival.
Antioxidant nanomedicine in sepsis: a narrative review with no reported outcomes or safety data
Antioxidant nanomedicine review explores sepsis treatment options
This narrative review discusses antioxidant nanomedicine for sepsis. The authors note that key details such as population, sample size, outc…
A review looks at antioxidant nanomedicine for sepsis, a serious infection that kills many people. More research is needed to see if this ap…
Systematic review and meta-analysis of sepsis screening tools in low- and middle-income countries
Sepsis screening tools show mixed accuracy in low-income country adult patient groups
This systematic review and meta-analysis evaluated sepsis screening tools in adult populations in low- and middle-income countries. It found…
A review of thirty thousand patients found that common sepsis checklists work differently in low-income areas. Some tools miss cases while o…
Systematic review of acupuncture for sepsis-associated acute gastrointestinal injury
Acupuncture helped some sick patients feel better but did not save more lives in this review
This systematic review and meta-analysis synthesized evidence on adjunctive acupuncture for sepsis-associated acute gastrointestinal injury …
This review looked at acupuncture for very sick people with stomach problems caused by sepsis. While it helped lower inflammation and improv…
Review discusses metabolic reprogramming of macrophages for sepsis-associated acute lung injury with noted limitations
Immune Cell Energy Switch Offers Hope Against Deadly Sepsis Lungs
This narrative review examines the concept of metabolic reprogramming of macrophages as a potential approach for sepsis-associated acute lun…
• Scientists reprogrammed immune cells to calm sepsis lung damage • Helps critically ill patients with few current options • Still in lab te…