Research across Osteoarthritis
Related studies from across the Osteoarthritis family.
Immune and chondrocyte ligand-receptor axes drive osteoarthritis progression and offer therapeutic targets
Scientists Map Immune Signals That May Drive Knee Arthritis
This narrative review examines immune-chondrocyte ligand-receptor (LR) axes in osteoarthritis, identifying cytokine, chemokine, DAMP-PRR, an…
A new review maps the immune signals that may push cartilage cells to break down in osteoarthritis, pointing to possible future treatment ta…
Macrophage-fibroblast interactions drive inflammatory amplification and cartilage-degrading enzyme production in osteoarthritis
Cell interactions drive inflammation and tissue damage in osteoarthritis
This mini review examines macrophage-fibroblast interactions in osteoarthritis. Findings suggest that macrophage signals increase fibroblast…
New research reveals how specific cell interactions drive the inflammation and tissue breakdown seen in osteoarthritis.
Telemedicine May Improve Pain and Function in Arthritis Patients
Telemedicine helps manage pain for patients with arthritis conditions
Telemedicine may improve pain, function, and quality of life in osteoarthritis and inflammatory arthritis, but evidence certainty is low.
Telemedicine shows promise in reducing pain and improving quality of life for people living with osteoarthritis and inflammatory arthritis.
Metabolic stress from obesity and hyperglycemia impairs macrophage efferocytosis in osteoarthritis joint environments
Metabolic Stress Linked to Joint Damage in Osteoarthritis
This mini review explores how metabolic stress, specifically obesity and hyperglycemia, impacts macrophage efferocytosis and joint homeostas…
New research identifies how obesity and high blood sugar may impair the body's ability to clear dead cells in joints, potentially worsening …
Non-steroidal anti-inflammatory drugs are a predictably effective first-line pharmacologic therapy for canine osteoarthritis
New guidelines offer a multi-step plan for dog joint pain
This clinical guideline provides a consensus-driven framework for managing osteoarthritis in adult dogs. It identifies non-steroidal anti-in…
New guidelines suggest a mix of nutrition, exercise, and medication to help dogs with osteoarthritis live more comfortable lives.
Kinematic vs Mechanical Alignment in Total Knee Arthroplasty: Similar Outcomes, Higher Preference
Kinematic Alignment Shows Specific Patient Preference in Knee Replacement
Kinematic alignment did not improve reoperation rates or patient-reported outcomes versus mechanical alignment, but bilateral patients prefe…
Patients with both knees replaced may prefer the kinematic alignment technique, even though overall surgical outcomes are similar to standar…
Immune-cell activation and metabolic dysfunction may interact to influence synovial inflammation and cartilage homeostasis in osteoarthritis
Immune and Metabolic Signals Linked to Osteoarthritis
This narrative review explores the interplay between immune and metabolic processes in osteoarthritis. The authors suggest that these intera…
Osteoarthritis may involve a two-way conversation between immune cells and metabolism, a new review suggests.
Ultrasound-guided peripheral nerve blocks provide analgesic benefits for patients with refractory osteoarthritis pain
Ultrasound-guided nerve blocks provide relief for chronic joint pain
This narrative review synthesizes evidence on ultrasound-guided peripheral nerve blocks for refractory osteoarthritis pain. The review indic…
Newer nerve block techniques using ultrasound may offer lasting pain relief for people with severe osteoarthritis that does not respond to s…
Lateral meniscal abnormalities do not significantly impact short- to mid-term outcomes after medial UKA
Lateral Meniscus Injuries May Not Affect Knee Surgery Outcomes
This meta-analysis of 1,709 patients with anteromedial osteoarthritis found that lateral meniscal abnormalities did not significantly impact…
A review of 1,709 patients suggests that certain lateral meniscus issues do not significantly impact recovery after specific knee replacemen…
Coumarins and derivatives may protect musculoskeletal health by modulating inflammatory and oxidative mediators
Coumarins may protect bone and joint health in several diseases
This systematic review examines the role of coumarins and their derivatives in managing musculoskeletal diseases including osteoporosis, rhe…
Coumarins and their derivatives may slow the progression of bone and joint diseases by targeting inflammation and specific cellular pathways…
Gut microbiota-targeted interventions reduce pain and function scores in patients with osteoarthritis
Gut health treatments may reduce pain for osteoarthritis patients
This meta-analysis of 18 trials involving 2,080 adults with osteoarthritis found that probiotics, prebiotics, and synbiotics significantly r…
Targeting the gut with probiotics and prebiotics may help ease pain and improve physical function for people living with osteoarthritis.
Immune signaling and bidirectional neuropeptide release drive nociceptor sensitization in osteoarthritis pain
Immune Signaling and Nerve Activity Drive Osteoarthritis Pain
This mini review explores the mechanisms of synovial inflammation and immune signaling in osteoarthritis. It describes how macrophages, T ce…
New research highlights how immune cells and nerve signals work together to create and amplify chronic pain in people with osteoarthritis.