Research across Parkinson's Disease
Related studies from across the Parkinson's Disease family.
Gut microbiota-associated signals may influence immune homeostasis and neuroinflammation in neurodegenerative diseases
Gut bacteria may influence immune health in the central nervous system
This systematic review explores how gut microbiota-associated signals, including short-chain fatty acids and bile acids, may influence immun…
Gut bacteria and their byproducts may influence immune responses and inflammation in the brain, potentially impacting several neurodegenerat…
Neuromelanin-sensitive MRI shows significant group-level differences in LC signal and volume in Parkinson's disease
MRI Imaging Shows Distinct Changes in Parkinson's Disease Patients
This meta-analysis of 1,078 participants with Parkinson's disease and 543 healthy controls found significantly lower LC signal (Hedges' g = …
New imaging data shows significant differences in brain signals for people with Parkinson's disease compared to healthy individuals.
STN-SNr co-stimulation adds no motor or gait benefit over STN-only in Parkinson's
Trial shows no added benefit for specific Parkinson's brain stimulation
This meta-analysis of 10 studies (109 evaluable participants) found no between-group difference for STN-SNr co-stimulation versus STN-only s…
New analysis shows that adding a second stimulation point in the brain does not improve movement for Parkinson's patients.
Higher GrimAge epigenetic age acceleration is significantly associated with higher dementia risk
GrimAge metric shows link to increased risk of dementia
This meta-analysis of 46,365 individuals with neurodegenerative diseases found that only the GrimAge metric showed a significant association…
One specific biological age clock, known as GrimAge, showed a link to higher dementia risk in a large study of over 46,000 people.
Dietary habits and eating behaviors significantly modulate drug disposition and clinical performance in Parkinson's disease
Dietary Habits Influence How Parkinson's Medications Work in the Body
This systematic review examines how various dietary patterns and eating behaviors influence the pharmacokinetics and clinical efficacy of Pa…
Specific eating patterns and dietary habits can change how Parkinson's medications are processed and how well they work for patients.
Photobiomodulation shows consistent anti-inflammatory effects but inconsistent clinical results in various neurodegenerative disorders
Red and near-infrared light may help certain brain disorders
This narrative review explores the role of photobiomodulation in treating Alzheimer's disease, Multiple Sclerosis, Parkinson's disease, and …
Red and near-infrared light therapy shows promise for some brain conditions, though results are mixed for others.
KRTCAP2 genetic burden and depression polygenic risk scores are associated with increased depression odds in Parkinson's
Genetic Factors Linked to Depression in Parkinson's Disease Patients
This meta-analysis of three population-based studies identifies genetic associations between specific genes and depression in Parkinson's di…
Specific genetic markers and a general risk score for depression were linked to higher rates of depression in patients with Parkinson's dise…
Transposable elements show widespread cell-type-specific dysregulation in Parkinson's substantia nigra
Transposable Elements Linked to Parkinson's Disease and Sex Differences
This meta-analysis synthesizes transposable element (TE) expression in the substantia nigra of donors with Parkinson's disease. It reports w…
New research identifies specific genetic elements that may contribute to Parkinson's disease and vary significantly between men and women.
Mind-body exercise shows largest posterior median effect for motor symptoms in Parkinson's disease
Mind-body exercise shows promise for managing Parkinson's disease symptoms
This systematic review and Bayesian network meta-analysis of 173 randomized trials evaluated exercise modalities and dose-response effects i…
Mind-body exercises may help manage motor symptoms and balance for people living with Parkinson's disease.
GALC and GBA1 loci are associated with altered enzyme activity ratios in Parkinson's disease
Genetic variants linked to enzyme balance in Parkinson's disease
This meta-analysis of genetic and enzymatic data from 1,290 individuals identifies significant associations between the GALC locus and the g…
New research identifies specific genetic markers that may affect how enzymes work together in people with Parkinson's disease.
HMGB1 acts as a progression-associated inflammatory amplifier in Alzheimer's, Parkinson's, and ALS models
New research explores a protein linked to several brain diseases
This narrative review explores the role of HMGB1 in various neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS. The auth…
A specific protein called HMGB1 may act as a driver of inflammation in conditions like Alzheimer's and Parkinson's disease.
Mesenchymal stromal cells and MSC-derived extracellular vesicles may reprogram neuroimmune responses in neurodegenerative diseases
Stem cells and vesicles show potential for neurodegenerative diseases
This critical review examines the mechanisms and translational barriers of mesenchymal stromal cells (MSCs) and MSC-derived extracellular ve…
New research explores how stem cell products might protect the brain and repair blood-brain barriers in diseases like Parkinson's and Alzhei…