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Home › Conditions › Premenstrual Dysphoric Disorder

Premenstrual Dysphoric Disorder

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Premenstrual Dysphoric Disorder

6 trials tracked for Premenstrual Dysphoric Disorder: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 87 citations.

6Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 3 1 Other / NA 2
  1. Phase 4 Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder Completed · 87 cited
  2. Phase 4 Continuous Oral Contraceptive Treatment in Premenstrual Dysphoric Disorder (PMDD) Completed · 41 cited
  3. Phase 4 The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder Completed
  4. Phase 3 Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study Completed
  5. N/A Premenstrual Hormonal and Affective State Evaluation (PHASE) Project Completed
  6. N/A Single Session of tACS in a Depressive Episode Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Prevalence of Premenstrual Dysphoric Disorder and Syndrome among female medical students in Saudi Arabia
Psychiatry Sys. Review
Prevalence of Premenstrual Dysphoric Disorder and Syndrome among female medical students in Saudi Arabia High Rates of PMS and PMDD Found Among Female Students
This descriptive study assessed the prevalence of premenstrual conditions and associated triggers among a cohort of female medical students.…
Over 40% of female medical students reported moderate to severe PMS, with stress identified as a major trigger for these symptoms.
Frontiers Jun 30, 2026
fMRI shows decreased activation in anterior cingulate cortex and increased activation in amygdala in women with premenstrual dysphoric disorder
Psychiatry Meta-analysis
fMRI shows decreased activation in anterior cingulate cortex and increased activation in amygdala in women with premenstrual dysphoric disorder Brain scans show PMDD linked to distinct activity patterns
This systematic review examined functional brain alterations in 598 participants, including 294 PMDD patients and 304 healthy controls. Wome…
Brain scans of women with PMDD show different activity in emotion and pain areas compared to healthy women, a review finds.
Frontiers Jun 4, 2026