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Diabetes & Endocrinology
RCT
AI prescreening tool identifies primary aldosteronism with AUROC 0.709 in hypertension
AI tool helps identify patients with high blood pressure condition
In a retrospective cohort of 22,264 adults with hypertension or PA testing, an AI prescreening tool using EHR data achieved an AUROC of 0.70…
A new AI tool uses electronic health records to help doctors find patients who need testing for a specific heart condition.
medRxiv
Oct 9, 2026
Diabetes & Endocrinology
Meta-analysis
MACS affects 26.2% of primary aldosteronism patients and tracks with higher cardiometabolic odds
Mild Cortisol Secretion Linked to Heart Risks in Aldosteronism
This meta-analysis of 2356 patients with primary aldosteronism estimates a pooled MACS prevalence of 26.2% (95% CI 24.1-28.4). MACS co-occur…
Patients with primary aldosteronism and mild cortisol secretion may face higher risks of heart issues and type 2 diabetes.
Oct 2, 2026
Diabetes & Endocrinology
Meta-analysis
Primary aldosteronism is associated with lower serum potassium and higher urinary albumin excretion
Primary aldosteronism shows distinct chemical markers compared to high blood pressure
This meta-analysis of 74 observational studies involving 26,143 participants identifies distinct biochemical and renal-metabolic profiles in…
Patients with primary aldosteronism show unique chemical markers and higher kidney protein levels than those with standard high blood pressu…
Frontiers
Sep 15, 2026
Cardiology
Meta-analysis
Genetic risk scores for Primary Aldosteronism identify blood pressure independent pathways for cardiovascular disease
Genetic Markers Linked to Heart Health in High Blood Pressure
This meta-analysis identifies 19 genetic loci associated with Primary Aldosteronism, including 13 new loci. The analysis suggests that a sub…
New research identifies 19 genetic markers for Primary Aldosteronism, showing how certain genes may impact heart health independently of blo…
medRxiv
Aug 18, 2026
Nephrology
Sys. Review
Concurrent primary aldosteronism and micro-pheochromocytoma can coexist in patients with paroxysmal hypertension
Surgery helps woman with complex high blood pressure and tumors
This case report describes a 65-year-old woman with paroxysmal hypertension who presented with concurrent primary aldosteronism and a micro-…
A 65-year-old woman found to have two different types of adrenal gland issues was successfully treated after surgery.
Frontiers
Jul 24, 2026
Diabetes & Endocrinology
Sys. Review
Review examines current endocrine causes of secondary osteoporosis and clinical management approaches
Why Normal Hormones Can Still Break Bones
This review synthesizes evidence on endocrine-related secondary osteoporosis across conditions like hypercortisolism and male hypogonadism.
You might think strong bones only come from aging women or older men.
Frontiers
Apr 21, 2026
Diabetes & Endocrinology
Sys. Review
Review of mineralocorticoid receptor antagonists and aldosterone synthase inhibitors for primary aldosteronism
High Blood Pressure Isn't the Only Danger
This narrative review examines the use of mineralocorticoid receptor antagonists and aldosterone synthase inhibitors in patients with primar…
Controlling your blood pressure is not enough to protect your heart if you have this specific type of high blood pressure.
Frontiers
Apr 16, 2026
Questions about Primary aldosteronism
Is there a link between primary aldosteronism and higher urinary albumin excretion?
Yes. A large meta-analysis found that people with primary aldosteronism have higher urinary albumin excretion than people with essential hypertension [1].
Full answer →Does primary aldosteronism cause lower potassium levels in the blood?
Yes. Primary aldosteronism is consistently linked to lower blood potassium levels, and the drop is larger in more severe or unilateral cases [1][2][6].
Full answer →