Mode
Text Size
Log in / Sign up

Procedural Pain

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Procedural Pain

10 trials tracked for Procedural Pain: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 9 citations.

10Trials tracked
5Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 4 Phase 3 1 Phase 2 1 Other / NA 4
  1. Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
  2. Phase 4 Regional Anesthesia Following Pediatric Cardiac Surgery Completed · 5 cited
  3. Phase 4 Comparison of Two Application Techniques for LET Gel Completed · 2 cited
  4. Phase 4 Addition of Buprenorphine to Paracervical Block for Pain Control During Osmotic Dilator Insertion Completed
  5. Phase 3 The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort Completed
  6. Phase 2 Pediatric Pain Optimization After Tonsillectomy Completed
Show 4 more trials
  1. N/A Evaluating the Feasibility of VR for Pediatric Renal Biopsies Completed
  2. N/A Crochet Octopus in The Process of Heel Lance in Neonates Completed
  3. N/A The Effect of Vibration and Cold on Pain and Anxiety Associated With Chest Tube Removal Following CABG Completed
  4. N/A Can Virtual Reality Reduce Pain and Anxiety During Blood Draw Completed

Showing the 10 most-cited and recently-updated of 10 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Procedural Pain: what the trials found

Pharmacological interventions have been evaluated for procedural pain management. The administration of Ropivacaine 0.2% injectable solution was associated with a significant reduction in the total amount of opioid medications administered (p=0.004) 4.

Local anesthetic agents, including Lidocaine 7 and a topical gel combination of LET Lidocaine (4%), Epinephrine (0.1%), and Tetracaine (0.5%), have been utilized in clinical settings [5, 7]. Additionally, Buprenorphine 0.15 MG was evaluated for pain management during osmotic dilator insertion, with reported pain scores at the time of insertion ranging from 3.0 to 4.0 and decreasing or remaining low at one and two hours post-insertion 6.

Recent results — preliminary, needs further review

  • The use of an Oculus Go Virtual Reality Headset was associated with significant reductions in self-reported procedural anxiety as measured by both the Childhood Anxiety Meter (p=0.001) and the Child Fear Scale (p=0.001) 1.
  • A vibration device demonstrated a statistically significant effect on anxiety levels (p=0.001) 2.

For the clinician treating this condition

  • Ropivacaine 0.2% injectable solution may reduce the requirement for systemic opioids during procedures 4.
  • Buprenorphine 0.15 MG has been shown to maintain low pain scores during and following osmotic dilator insertion 6.

AI synthesis of 5 cited trials, updated Jul 3, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.