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Home › Conditions › Rabies

Rabies

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Rabies

16 trials tracked for Rabies: 12 in phase 3 or 4 and 5 with published results. The most-cited published study has 57 citations.

16Trials tracked
12Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 3 Phase 3 9 Phase 2 1 Phase 1 2 Other / NA 1
  1. Phase 3 Simplifying the Rabies Pre-exposure Vaccination Completed · 57 cited
  2. Phase 3 A Phase III Clinical Study to Evaluate SYN023's Efficacy and Safety Completed · 20 cited
  3. Phase 4 Immunogenicity of Rabies Vaccine for Pre Exposure Prophylaxis Completed · 13 cited
  4. Phase 4 Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis. Completed · 11 cited
  5. Phase 3 Study of Purified Vero Rabies Vaccine Compared With Two Reference Rabies Vaccines, Given in a Pre-exposure Regimen to Children and Adults and as Single Booster Dose to a Subset of Adults Completed · 4 cited
  6. Phase 4 Immunogenicity and Safety of Rabies Vaccine, Administered With Two Different Simulated Post Exposure Schedules Completed
Show 10 more trials
  1. Phase 3 Phase II/III Study of the Safety and Effectiveness of HRIG With Active Rabies Vaccine in Healthy Subjects Completed
  2. Phase 3 A Phase 3 Clinical Trial to Evaluate Long-term Immunogenicity and Boostability of Purified Chick-Embryo Cell Rabies Vaccine in Adults Following Primary Series of Pre/Exposure Prophylaxis. Completed
  3. Phase 3 Safety and Immunogenicity (Non-inferiority) of a Purified Chick Embryo Cell Vaccine Vaccine Administered in Two Different Schedules (Conventional Versus Abbreviated Schedule) Completed
  4. Phase 3 Safety and Immunogenicity of 2 Different Vaccination Schedules of Rabies and Japanese Encephalitis Vaccines in Healthy Adult Subjects Completed
  5. Phase 3 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed
  6. Phase 3 A Randomized, Open-label Study Comparing Two Different Rabies Vaccine Schedules in Chinese Children and Older Adults Completed
  7. Phase 2 Comparison of SYN023 to Human Rabies Immune Globulin in Post Exposure Prophylaxis of Rabies Completed
  8. Phase 1 A Study to Assess the Safety, Reactogenicity and Immune Response of CureVac's Candidate Rabies mRNA Vaccine in Healthy Adults Completed
  9. Phase 1 Dosage-Escalation Study of the Safety and Immunogenicity of a Novel Rabies Vaccine ChAd155-RG vs. the Comparator RABAVERT Vaccine in Healthy Adult Subjects Completed
  10. N/A Immune Response After Booster Vaccination in HIV - Infected Patients Who Received Rabies Primary Vaccination Completed

Showing the 16 most-cited and recently-updated of 16 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Rabies: what the trials found

Several rabies vaccine formulations demonstrate high efficacy in inducing protective humoral immune responses. The SYN023 vaccine showed a high percentage of participants with Rabies Virus Neutralizing Activity (RVNA) ≥0.5 IU/mL at Day 99 1 and in other cohorts 6. The purified vero rabies vaccine - serum free - VRVg-2 demonstrated near-universal seroconversion (≥0.5 IU/mL) across pooled populations 7. Additionally, an active rabies vaccine showed 100% of subjects achieving RVNA ≥0.5 IU/mL at 7 days post-vaccination and 99-100% reaching PRNT50 titers ≥1:10 at 28 days post-vaccination 10.

Specific dosing schedules have been evaluated for efficacy and non-inferiority. The abbreviated Zagreb 2-1-1 schedule achieved 100% seroconversion by Day 42 13, while the standard Zagreb schedule was found to be non-inferior to the Essen schedule in both children and older adults 11. Rabipur showed stable RVNA concentrations over a three-year period, with significant increases in antibody concentration following booster doses 8.

The Purified Chick Embryo Cell Inactivated Rabies Vaccine (PCECV) was evaluated for additional value; results showed that the addition of a fifth dose did not significantly change the percentage of subjects achieving protective titers compared to four doses 3. Furthermore, concurrent administration of rabies and Japanese Encephalitis vaccines with MenACWY-CRM197 resulted in 100% of subjects reaching RVNA concentrations ≥0.5 IU/mL 12.

Safety profiles for Rabipur indicate that local and systemic solicited adverse events (AEs) were generally low in frequency and severity following the first dose 14.

Recent results — preliminary, needs further review

  • ChAd155-RG was evaluated for reactogenicity, but results regarding serious adverse events are not yet corroborated 15.
  • A study investigating rabies vaccines administered on days 0 and 3 is currently under review/not yet corroborated 16.

For the clinician treating this condition

  • Multiple vaccine platforms (SYN023, VRVg-2, and active US-FDA approved vaccines) consistently achieve high rates of protective RVNA titers.
  • Both the Zagreb and Essen postexposure schedules are established as effective; the abbreviated Zagreb 2-1-1 schedule shows high seroconversion rates by day 42.
  • Rabipur maintains stable antibody levels over three years, with booster doses providing significant increases in RVNA concentrations.

AI synthesis of 12 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Three Human Rabies Deaths in the United States Attributed to Bat Exposures
Infectious Disease
Three Human Rabies Deaths in the United States Attributed to Bat Exposures Three people died from rabies after bat exposures. What happened?
A case report describes three human rabies deaths in the United States attributed to bat exposures.
Three people in the United States died from rabies after bat exposures, proving the disease remains fatal and preventable only with prompt m…
CDC Apr 6, 2026
Case report describes rabies in a dog imported from Azerbaijan to the United States
Infectious Disease
Case report describes rabies in a dog imported from Azerbaijan to the United States A dog imported from Azerbaijan brought rabies to the United States
A case report describes a single case of rabies in a dog imported from Azerbaijan to the United States.
A rabies-infected dog imported from Azerbaijan to the United States highlights the real-world risk of bringing diseases across borders.
CDC Apr 5, 2026
Case report describes human rabies in Texas boy after bat bite
Infectious Disease
Case report describes human rabies in Texas boy after bat bite A boy in Texas got rabies after a bat bite. What does this tell us?
A case report describes a young boy in Texas who developed rabies after a bat bite.
A Texas boy developed rabies after a bat bite, proving the disease can spread to humans and remains almost always fatal once symptoms start.
CDC Apr 5, 2026
132 imported dogs identified with potentially ineffective rabies vaccination
Infectious Disease
132 imported dogs identified with potentially ineffective rabies vaccination Why are dogs arriving in the US with questionable rabies protection?
A field report identified 132 dogs imported into the U.S.
A recent check found 132 dogs entering the U.S. from rabies-heavy countries had vaccination records that might not work.
CDC Apr 5, 2026
ACIP Updates Rabies Preexposure Prophylaxis Vaccination Recommendations for At-Risk Individuals
Allergy & Immunology
ACIP Updates Rabies Preexposure Prophylaxis Vaccination Recommendations for At-Risk Individuals U.S. health officials update recommendations for rabies prevention vaccination schedule
The Advisory Committee on Immunization Practices has issued updated recommendations for a modified rabies preexposure prophylaxis vaccinatio…
U.S. health officials updated rabies prevention schedules for at-risk workers and travelers, offering new expert guidance on when to get sho…
CDC Apr 4, 2026
Case report describes fatal rabies in US organ transplant recipient from undiagnosed donor
Infectious Disease
Case report describes fatal rabies in US organ transplant recipient from undiagnosed donor Patient dies after receiving organ transplant from donor with undiagnosed rabies
A case report describes a patient in the United States who died after receiving a solid organ transplant from a donor with undiagnosed rabie…
A patient in the United States died after receiving a transplant from a donor with undiagnosed rabies, a very rare event that highlights the…
CDC Apr 4, 2026
Case report describes fatal rabies in a child from Pedernales, Dominican Republic
Pediatrics
Case report describes fatal rabies in a child from Pedernales, Dominican Republic Child dies from rabies in Dominican Republic, according to field investigation report
A field investigation case report describes a child from Pedernales, Dominican Republic who died after developing clinical signs consistent …
A child in the Dominican Republic died after developing signs consistent with rabies, highlighting the continued risk of this disease in som…
CDC Apr 4, 2026
Case report describes cluster of rabid steers on Minnesota dairy farm infected by single skunk
Infectious Disease
Case report describes cluster of rabid steers on Minnesota dairy farm infected by single skunk Single skunk infected multiple steers with rabies on Minnesota dairy farm
A case report describes a cluster of rabid steers on a Minnesota dairy farm infected by a single skunk.
A single skunk infected multiple steers with rabies on a Minnesota dairy farm, showing how one animal can spread the virus to others.
CDC Apr 4, 2026

Questions about Rabies

How can a child in the Dominican Republic die from rabies?

A child in the Dominican Republic died from rabies after being bitten by an infected animal, likely a dog, which allowed the virus to travel to the brain and cause fatal brain swelling.

Full answer →
Can a bat bite in Texas lead to fatal human rabies?

Yes, a bat bite in Texas can lead to fatal human rabies, as confirmed by a specific case report of a boy who died after being bitten by a bat in that state.

Full answer →
Is it possible for an imported dog to bring rabies to the US?

Yes, an imported dog can bring rabies to the US, as documented by a specific case where a dog from Azerbaijan was found to have the disease upon arrival.

Full answer →
Can a bat exposure cause human rabies death in the United States?

Yes, bat exposure can cause fatal human rabies in the United States, as bats are the primary source of domestically acquired cases and have caused recent deaths.

Full answer →