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Home › Conditions › Schistosomiasis

Schistosomiasis

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Schistosomiasis

7 trials tracked for Schistosomiasis: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 35 citations.

7Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 3 Phase 1 2 Other / NA 1
  1. Phase 3 L-PZQ ODT in Schistosoma Infected Children Completed · 35 cited
  2. Phase 2 Praziquantel in Children Under Age 4 Completed
  3. Phase 2 S. Japonicum and Pregnancy Outcomes Completed
  4. Phase 2 An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni) Completed
  5. Phase 1 Safety, Tolerability, and Immunogenicity Study of Sm-p80 + GLA-SE (SchistoShield(R)) Vaccine in Healthy Adults Completed
  6. Phase 1 A Study to Evaluate the Safety, Tolerability, and Immunogenicity of the rSm-p80 + GLA-SE (SchistoShield®) Candidate Vaccine in Healthy Adults in Burkina Faso and Madagascar Completed
Show 1 more trials
  1. N/A Health Education Model Led by Community Health Volunteers. Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Schistosomiasis: what the trials found

Praziquantel is established as an effective intervention for schistosomiasis, with high egg reduction rates observed in multiple cohorts (up to 99.5%) 3. Clinical safety data indicates that praziquantel is well-tolerated during pregnancy; studies showed no significant differences in newborn birth weight, live birth rates, or maternal hemoglobin levels across treatment groups (p > 0.926) 5.

Health education programs have been shown to significantly improve knowledge scores among participants 7.

Recent results — preliminary, needs further review

  • [  ] The rSm-p80 + GLA-SE vaccine candidate showed a low incidence of clinical safety laboratory adverse events (0-4 cases) across different dose formulations 2.
  • [  ] Sm-p80 was evaluated for reactogenicity and laboratory adverse events in early phase studies 6.

For the clinician treating this condition

  • Praziquantel remains a highly effective treatment with high egg reduction rates and a favorable safety profile in pregnant patients [3, 5].
  • Health education is an effective non-pharmacological intervention to improve patient knowledge regarding the condition 7.

AI synthesis of 5 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Explainable artificial intelligence offers a structured framework to improve neglected tropical disease diagnosis
Neurology Sys. Review
Explainable artificial intelligence offers a structured framework to improve neglected tropical disease diagnosis Explainable artificial intelligence could improve diagnosis of neglected tropical diseases
This narrative review explores the role of explainable artificial intelligence (XAI) in diagnosing neglected tropical diseases like malaria …
New research explores how explainable AI can help doctors identify and treat overlooked infections like malaria in areas with limited resour…
Frontiers Aug 11, 2026
Environmental DNA and next-generation sequencing offer potential for post-elimination surveillance of neglected tropical diseases
Radiology & Imaging Sys. Review
Environmental DNA and next-generation sequencing offer potential for post-elimination surveillance of neglected tropical diseases New DNA tracking methods could help stop tropical diseases
This narrative review explores the use of environmental DNA (eDNA) and next-generation sequencing (NGS) for monitoring lymphatic filariasis,…
Scientists are looking at how environmental DNA can track hidden parasites and worms to keep communities safe after initial treatments succe…
Frontiers Aug 5, 2026
Schistosomiasis infection increases odds of malaria co-infection by 1.27 in children and adolescents
Pediatrics Meta-analysis
Schistosomiasis infection increases odds of malaria co-infection by 1.27 in children and adolescents Schistosomiasis infection increases risk of malaria in African children
This systematic review and meta-analysis of 30 studies involving children and adolescents in Sub-Saharan Africa indicates that schistosomias…
Children with schistosomiasis have higher odds of also having malaria, especially those who have direct contact with water.
Jun 16, 2026
Prior Exorchis infection blocks S. japonicum in snails: a narrative review
Allergy & Immunology Sys. Review
Prior Exorchis infection blocks S. japonicum in snails: a narrative review Snail parasite blocks schistosomiasis infection, researchers find
This narrative review examines competitive exclusion in Oncomelania hupensis snails, finding that prior infection with Exorchis sp. can comp…
A parasite in snails may block schistosomiasis, a disease affecting millions worldwide.
Frontiers May 29, 2026
Meta-analysis finds AI tools show high accuracy for Schistosoma haematobium detection in sub-Saharan Africa
Radiology & Imaging Meta-analysis
Meta-analysis finds AI tools show high accuracy for Schistosoma haematobium detection in sub-Saharan Africa AI tools show high accuracy for detecting a parasitic infection in Africa
This meta-analysis of 10 studies in sub-Saharan Africa synthesized the diagnostic accuracy of AI-assisted tools for Schistosoma haematobium …
A review of studies in Africa found AI tools can accurately detect a parasitic infection in urine samples, offering a promising new screenin…
May 12, 2026

Questions about Schistosomiasis

Does a child with schistosomiasis have higher odds of having malaria?

Yes, a child with schistosomiasis has about 1.27 times higher odds of also having malaria, based on a 2026 meta-analysis.

Full answer →
Does having schistosomiasis increase the risk of malaria in children?

Yes, having schistosomiasis is linked to a higher chance of malaria in children, with about 1.27 times higher odds of co-infection.

Full answer →