Research across Sepsis
Related studies from across the Sepsis family.
Dendritic cells bridge innate and adaptive immunity but suffer dysfunction during sepsis-induced immunoparalysis
Dendritic cells play a vital role in fighting sepsis
This systematic review examines the role of dendritic cells (DCs) in the immunopathology of sepsis. The authors conclude that while DCs are …
Dendritic cells act as a critical bridge in the immune system, but sepsis can cause them to fail, leading to dangerous immune suppression.
Malignancy linked to higher mortality in sepsis, with pooled odds ratios up to 2.41
Cancer Diagnosis Impacts Survival Rates for Patients with Sepsis and Septic Shock
This systematic review and meta-analysis of 105 studies (20,089,138 participants) examined mortality among adults with sepsis or septic shoc…
Patients with cancer face a much higher risk of death when they develop sepsis. This study looks at how cancer affects survival.
Sivelestat-containing regimens reduce all-cause mortality in sepsis-induced ARDS with OR 0.55
Sivelestat shows lower mortality for patients with sepsis and ARDS
This meta-analysis of 943 patients found that a sivelestat-containing regimen significantly reduced all-cause mortality in sepsis-induced AR…
A new review of data suggests the drug sivelestat may lower death rates for adults with severe lung and blood infections.
High THBS1 expression is associated with poorer outcomes in patients with sepsis
High THBS1 levels linked to poorer outcomes in sepsis patients
This meta-analysis of public datasets and an exploratory cohort identifies THBS1 as a candidate molecule for myeloid immune responses in sep…
A new look at medical data shows that high levels of a specific protein marker may signal a higher risk for sepsis patients.
AI decision support improves detection in bounded tasks but not in open-ended reasoning
AI Tools Show Mixed Results in Cancer and Sepsis Detection
This narrative review examines the impact of AI decision support and large language models on clinician performance in cancer and sepsis. Th…
AI tools may help doctors find more cancer and reduce workload, but they do not improve complex reasoning or always ensure consistent accura…
Heparin Shows No Mortality Benefit in Sepsis Meta-Analysis of 426 Patients
Heparin treatment shows mixed results for patients with sepsis
This meta-analysis examined heparin use in critically ill patients with sepsis, pooling data from 426 patients. No significant mortality red…
New data on heparin for sepsis shows it does not significantly reduce death rates, and its role in blood clotting remains unclear.
MitoQ acts as an upstream mitochondrial redox modulator to attenuate oxidative injury in SALI
MitoQ may protect lung cells from damage during severe infection
This narrative review explores the role of MitoQ in treating sepsis and acute lung injury. The authors suggest MitoQ may mitigate mitochondr…
A new review suggests the compound MitoQ could protect lung tissue and energy production during severe infections like sepsis.
Hemodiafiltration in Neonates: Narrative Review Maps Applications but Reports No Clinical Outcomes
Hemodiafiltration in Babies: What We Still Do Not Know
This narrative review examines hemodiafiltration (HDF) in neonates and infants, focusing on clinical applications, potential benefits, safet…
A new review looks at hemodiafiltration for newborns and infants, but reports no actual results or safety data.
Higher H3.1 nucleosome levels associate with 48% increased 28-day mortality in septic shock
H3.1 Nucleosome Levels Linked to Sepsis Mortality and Kidney Risk
This secondary analysis of a multicenter randomized controlled trial involved 971 patients with sepsis and septic shock. Higher plasma H3.1 …
Higher levels of H3.1 nucleosomes in patients with sepsis and septic shock are linked to a higher risk of death and need for kidney replacem…
Phoenix Sepsis Criteria outperforms IPSCC criteria for pediatric in-hospital mortality risk stratification
New criteria improve risk prediction for children with sepsis
This meta-analysis of 15 studies and 16 cohorts involving 2,601,038 encounters evaluates the Phoenix Sepsis Criteria (PSC) compared to IPSCC…
A new scoring system helps doctors better predict which children with severe infections are at the highest risk of dying in the hospital.
Feasibility study for meropenem versus piperacillin/tazobactam in sepsis shows 30.5% 30-day mortality
Trial Tests Meropenem for Treatment of Sepsis in Critical Care
This feasibility study of 200 critically ill adults with sepsis in 10 Danish ICUs evaluated the trial's operational viability. The study rep…
A new feasibility study explores the use of meropenem to treat critically ill adults suffering from sepsis in intensive care units.
Sepsis-associated delirium affects 43% of ICU patients, mechanical ventilation strongest risk factor
Risk Factors Linked to Delirium in Patients with Sepsis
This meta-analysis of 89,789 ICU patients estimates the pooled incidence of sepsis-associated delirium (SAD) at 43% (95% CI 39%-47%). Higher…
A large review of ICU patients identifies key risk factors, such as advanced age and mechanical ventilation, for developing delirium during …