Research across Sepsis
Related studies from across the Sepsis family.
Tachypnoea at 60 breaths per minute increases odds of mortality in infants with sepsis
Rapid breathing in infants linked to higher sepsis mortality
This meta-analysis evaluates the association between tachypnoea and mortality or culture-confirmed sepsis in infants aged 0 to 59 days. Tach…
Fast breathing rates can signal a serious risk of death in newborns with sepsis, helping doctors identify the most at-risk infants more quic…
IgM-enriched immunoglobulin shows directionally favorable but statistically inconclusive results for short-term mortality in sepsis
IgM Therapy for Sepsis Shows Promise but Not Proof
This meta-analysis of 411 adults with sepsis or septic shock found that IgM-enriched immunoglobulin (Pentaglobin) showed a favorable trend f…
A new analysis hints IgM therapy may lower sepsis deaths, but the evidence isn't strong enough to recommend it yet.
Sepsis-induced neuromuscular dysfunction affects 60% of ICU adults, pooled meta-analysis finds
More than half of sepsis patients experience muscle weakness
This meta-analysis of 596 adult ICU patients with sepsis found a pooled SIND prevalence of 60% (95% CI 50-70%), with ICU-acquired neuromuscu…
A new look at intensive care data shows that 60% of adults with sepsis suffer from significant muscle dysfunction.
Skin perfusion parameters Mottling Score, CRT, and PPI correlate with higher mortality in sepsis patients
Skin Perfusion Markers Linked to Higher Sepsis Mortality Risk
This meta-analysis of 22 articles involving 2,727 subjects indicates that skin perfusion markers are associated with increased mortality ris…
Specific skin signs like mottling and slow capillary refill may help doctors identify patients with sepsis who are at a higher risk of death…
Plasma ANXA3 shows superior predictive accuracy for sepsis compared to PCT, IL-6, and SOFA
Protein levels may help doctors predict life-threatening sepsis faster
This meta-analysis and retrospective cohort study evaluate Annexin A3 (ANXA3) as a biomarker for sepsis. The analysis found that plasma ANXA…
A specific protein called ANXA3 shows more promise than current markers at predicting sepsis and identifying high-risk patients in intensive…
Sepsis, not breastfeeding, and no KMC significantly increase mortality risk in low birth weight neonates
Several Factors Linked to Higher Mortality in Low Birth Weight Infants
This meta-analysis of observational studies evaluates predictors of mortality in 7539 low birth weight neonates in Ethiopia. The analysis id…
A large meta-analysis identifies several key factors, including sepsis and lack of breastfeeding, linked to higher mortality in low birth we…
Bleeding, sepsis, and liver impairment each independently raise thrombocytopenia risk in ICU patients
Critical illness factors linked to lower platelet counts in patients
This meta-analysis of 27,147 critically ill patients found that bleeding (OR 3.49), sepsis (OR 2.32), and impaired liver function (OR 1.55) …
New data shows that bleeding, sepsis, and liver issues significantly increase the risk of low platelets in critically ill patients.
Age, male sex, low BMI, and comorbidities like diabetes are significant risk factors for sepsis incidence
Age, diabetes, and COPD raise sepsis risk, meta-analysis finds
This meta-analysis of 21 studies identifies several significant risk factors associated with increased sepsis incidence, including age over …
A new analysis of 21 studies pinpoints key risk factors for sepsis, including age, diabetes, and COPD.
Early postnatal antibiotic exposure increases BPD risk in very preterm infants across 11 studies
Early Antibiotic Exposure Linked to Risks for Very Preterm Infants
This meta-analysis of 11 studies indicates that early postnatal antibiotic exposure is associated with an increased risk of bronchopulmonary…
Early antibiotic use in very preterm infants is linked to higher risks of lung issues, intestinal damage, and mortality.
Toll-like receptor signaling governs inflammatory phenotypes and progression in infectious myocarditis
Toll-like receptors shape severity of infectious myocarditis
This systematic review examines the role of toll-like receptors (TLRs) in infectious myocarditis associated with COVID-19, influenza, and se…
A systematic review finds that pathogen-specific TLR signaling determines inflammation and outcomes in infectious myocarditis, with COVID-19…
HMGB1 and LPS interactions provide potential therapeutic targets for inflammation and coagulation in sepsis
New research identifies how specific proteins drive sepsis inflammation
This narrative review explores the mechanistic roles of Lipopolysaccharide (LPS) and High Mobility Group Box 1 (HMGB1) in sepsis. The author…
Scientists have identified a specific interaction between two molecules that triggers severe inflammation and organ failure during sepsis.
Sepsis is an inflammation-driven immune reprogramming disorder characterized by time-resolved trajectories and biologically defined subtypes
New research reframes sepsis as an immune reprogramming disorder
This narrative review explores the pathophysiology of sepsis as a dynamic immune reprogramming disorder involving hyperinflammation and low-…
Sepsis is more than just a severe infection; it is now being understood as a complex failure of the body's immune system.