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Home › Conditions › trachoma

Trachoma

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for trachoma

6 trials tracked for trachoma: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 34 citations.

6Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 1 1 Other / NA 2
  1. Phase 4 Partnership for Rapid Elimination of Trachoma Completed · 34 cited
  2. Phase 4 Azithromycin Reduction to Reach Elimination of Trachoma Completed · 5 cited
  3. Phase 4 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed
  4. Phase 1 Safety and Immunogenicity of a Chlamydia Vaccine CTH522 Completed
  5. N/A Modified Instrumentation for Surgery to Correct Trichiasis Completed
  6. N/A A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Trachoma: what the trials found

Azithromycin is established as a primary intervention for trachoma in large-scale clinical evaluations [1, 3].

Long-term monitoring of community prevalence of Trachoma and Ocular C. Trachomatis (CT) infection following azithromycin treatment showed no statistically significant difference across various groups at 36 months (p=0.22) 2.

Recent results — preliminary, needs further review

  • Surveillance and treatment with azithromycin for newcomer and traveler families did not show a statistically significant difference in the proportion of communities with C. Trachomatis infection prevalence of 1% or below (p=>0.05) 5.
  • The use of azithromycin for newcomer and traveler families did not result in a statistically significant difference in the proportion of communities with clinical trachoma prevalence of 5% or below (p=1) 5.
  • CTH522-CAF01 IM is currently undergoing early-phase investigation but results are not yet corroborated 4.
  • The TT Clamp is under investigation but findings are not yet corroborated 6.

For the clinician treating this condition

  • Azithromycin is a standard intervention for trachoma, supported by large-scale phase 4 trials [1, 3].
  • Long-term community prevalence of Trachoma and Ocular C. Trachomatis (CT) infection did not show significant changes at the 36-month mark following azithromycin administration 2.

AI synthesis of 4 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Evaluating Enhanced Intervention Strategies for Trachoma Elimination in Rural Ethiopian Communities
Infectious Disease RCT
Evaluating Enhanced Intervention Strategies for Trachoma Elimination in Rural Ethiopian Communities Enhanced treatment shows no extra benefit for children with trachoma
A cluster-randomized trial evaluates if adding fly control and hygiene behaviors to azithromycin dosing reduces trachoma prevalence.
A three-year study in Ethiopia found that adding extra fly control and hygiene measures did not lower infection rates more than standard dru…
Jul 4, 2026
Enhanced face-washing intervention increases soap use in trachoma-endemic Ethiopia
Pediatrics RCT
Enhanced face-washing intervention increases soap use in trachoma-endemic Ethiopia Free wash stations helped families in Ethiopia wash faces with soap more often
This cluster-randomised trial in 204 Ethiopian households found that an enhanced face-washing intervention increased face-washing prevalence…
A new program in Ethiopia gave families free wash stations and taught them to use soap. This simple change boosted face washing rates among …
May 1, 2026