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Home › Conditions › uterine atony

Uterine atony

Part of Obstetric Labor Complications

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for uterine atony

6 trials tracked for uterine atony: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 61 citations.

6Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 3 1 Phase 2 1 Other / NA 1
  1. Phase 4 Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial Completed · 61 cited
  2. Phase 3 Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery Completed · 12 cited
  3. Phase 4 Oxytocin And Uterotonic Agent Use For Cesarean Delivery Completed
  4. Phase 4 Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT Completed
  5. Phase 2 Calcium Chloride for Prevention of Uterine Atony During Cesarean Completed
  6. N/A Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Uterine atony: what the trials found

Management of uterine atony involves various pharmacological interventions. 15-methyl prostaglandin F2α has been evaluated for its effect on uterine tone scores 1. Oxytocin is a standard intervention, with large-scale data showing that the risk of requiring increased doses based on pre-specified factors was not statistically significant (p=0.670) 3.

Calcium chloride has also been utilized in clinical settings for this condition. While it showed no statistically significant difference in uterine tone numerical rating scores at 7 minutes post-delivery (p=0.415) or 12 minutes post-delivery (p=0.566), it was associated with a statistically significant difference in quantitative blood loss (p=<0.05) 4. Additionally, calcium chloride administration resulted in a maximum heart rate increase from baseline of 15.4 and 14.2 beats per minute respectively 5.

Recent results — preliminary, needs further review

  • Uterine cooling is currently under investigation but remains unconfirmed.

For the clinician treating this condition

  • Oxytocin is established as a treatment, with evidence suggesting that the need for increased doses based on specific risk factors was not statistically significant.
  • Calcium chloride shows a statistically significant impact on quantitative blood loss compared to alternatives, despite no significant difference in uterine tone scores at 7 or 12 minutes post-delivery.

AI synthesis of 4 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
General Anesthesia Associated With Increased Severe Postpartum Hemorrhage Risk Compared to Neuraxial Anesthesia in Cesarean Deliveries
Emergency Medicine Cohort
General Anesthesia Associated With Increased Severe Postpartum Hemorrhage Risk Compared to Neuraxial Anesthesia in Cesarean Deliveries General anesthesia in emergency cesareans linked to higher severe bleeding risk compared to neuraxial options
This retrospective dual-cohort study evaluated patients receiving general or neuraxial anesthesia during emergency cesarean deliveries and p…
Patients receiving general anesthesia during emergency cesarean deliveries faced nearly three times the risk of severe bleeding compared to …
Frontiers Apr 22, 2026