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Home › Conditions › uterine prolapse

Uterine prolapse

Part of Pelvic organ prolapse

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for uterine prolapse

8 trials tracked for uterine prolapse: 5 in phase 3 or 4 and 1 with published results. The most-cited published study has 23 citations.

8Trials tracked
5Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 5 Other / NA 3
  1. Phase 4 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Completed · 23 cited
  2. Phase 4 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Completed
  3. Phase 4 Efficacy Study of Vaginal Mesh for Anterior Prolapse Completed
  4. Phase 4 Lessons on Urethral Lidocaine in Urodynamics Completed
  5. Phase 4 Outcomes of Anterior Colporrhaphy Versus Graft Reinforced Anterior Prolapse Repair Completed
  6. N/A Efficacy Study of Vaginal Mesh for Prolapse Completed
Show 2 more trials
  1. N/A A Randomized Controlled Trial of Permanent vs Absorbable Suture for Uterosacral Ligament Suspension Completed
  2. N/A Prediction of Postsurgical Symptomatic Outcomes With Preoperative Pessary Use Completed

Showing the 8 most-cited and recently-updated of 8 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Uterine prolapse: what the trials found

Surgical interventions for uterine prolapse show varying results regarding anatomical success and complication rates. Synthetic polypropylene mesh was evaluated for anterior prolapse, with a reported objective treatment success rate of 10% to 12% at one year 3. Grafted anterior prolapse repair demonstrated significantly lower rates of recurrent Stage II or greater anterior vaginal prolapse (11% vs. 24%, p=0.005) compared to other methods, while showing no significant difference in operative time (p=0.5) but a statistically significant difference in vaginal mesh exposure (p<0.05) 5.

Pharmacological and supportive interventions provide different clinical outcomes. Conjugated Estrogens Cream was evaluated in a Phase 4 study 1. Water-based vaginal lubricants were associated with voiding efficiency metrics of 94.6% and 95.9% 2. In surgical settings involving Rocuronium, peak airway pressures showed significant variation (p=0.01), while abdominal insufflation pressure and surgical rating scales did not show statistically significant differences (p=0.28, p=0.63 respectively) 4.

Recent results — preliminary, needs further review

  • Synthetic monofilament polypropylene mesh was associated with an anatomic cure at 3 years in a subset of patients (p<0.05) 6.
  • Preoperative pessary use was associated with significant improvements in both prolapse symptom severity and the bother of bladder/vaginal/bowel symptoms (p=0.001) 7.
  • The use of absorbent suture (polydioxanone) combined with permanent suture (Gore-Tex CV2) was evaluated regarding POP-Q Point C measurements 8.

For the clinician treating this condition

  • Grafted anterior prolapse repair significantly reduces the rate of recurrent Stage II or greater anterior vaginal prolapse compared to other surgical techniques 5.
  • Surgical outcomes for synthetic polypropylene mesh show specific success rates for anatomical correction at one year 3.
  • Preoperative pessary use is associated with significant improvements in patient-reported symptom severity and related bothers 7.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review finds 54.8% of Indian women with reproductive morbidities seek treatment
OB/GYN & Women's Health Meta-analysis
Systematic review finds 54.8% of Indian women with reproductive morbidities seek treatment Half of Indian women ignore reproductive pain
This systematic review and meta-analysis examined health-seeking behavior for reproductive morbidities among Indian women.
Ignoring common reproductive problems like pelvic pain or irregular periods leads to worse health outcomes for millions of women in India.
Frontiers Apr 11, 2026

Research across Pelvic organ prolapse

Related studies from across the Pelvic organ prolapse family.

Systematic review of 41 RCTs evaluates surgical options for anterior compartment prolapse
ENT (Otolaryngology) Sys. Review
Systematic review of 41 RCTs evaluates surgical options for anterior compartment prolapse Researchers find prolapse surgery risks vary by method used
This systematic review synthesizes data from 41 randomized controlled trials involving 4531 women with anterior compartment prolapse.
Women choosing prolapse surgery face different risks depending on the method used, with long-term safety for mesh still unknown.
Cochrane Apr 25, 2026