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Home › Medications › acetaminophen

acetaminophen

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of acetaminophen

129 trials tracked of acetaminophen: 62 in phase 3 or 4 and 14 with published results. The most-cited published study has 375 citations.

129Trials tracked
62Phase 3 & 4
0Recruiting
14With published results
Phase distribution
Phase 4 45 Phase 3 17 Phase 2 41 Phase 1 9 Other / NA 17
  1. Phase 3 Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A Completed · 375 cited
  2. Phase 3 Acetaminophen Versus Ibuprofen in Children With Asthma Completed · 80 cited
  3. Phase 4 Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients Completed · 77 cited
  4. Phase 4 Effect of Race/Ethnicity and Genes on Acetaminophen Pharmacokinetics Completed · 68 cited
  5. Phase 4 Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout Completed · 54 cited
  6. Phase 3 Maxigesic 325 Acute Dental Pain Study Completed · 39 cited
Show 44 more trials
  1. Phase 4 Intravenous Acetaminophen in Craniotomy Completed · 35 cited
  2. Phase 4 Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment Completed · 24 cited
  3. Phase 3 Safety, Efficacy, and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients Completed · 24 cited
  4. Phase 4 Modified Pre-operative Oral Doses Acetaminophen Versus Intravenous Acetaminophen Completed · 19 cited
  5. Phase 4 Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises? Completed · 15 cited
  6. Phase 4 Single Dose Preoperative Gabapentin Use in Minimally Invasive Hysterectomy for Acute Pain Management Completed · 11 cited
  7. Phase 4 OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients Completed · 6 cited
  8. Phase 4 A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery Completed · 6 cited
  9. Phase 4 Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults Completed
  10. Phase 4 The Effect of NSAID Use in the Acute Phase of Skeletally Immature Bone Healing: A Prospective Study Completed
  11. Phase 4 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed
  12. Phase 4 Pre-emptive Analgesics in Orthodontic Treatment Completed
  13. Phase 4 TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy Completed
  14. Phase 4 The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy Completed
  15. Phase 4 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed
  16. Phase 4 Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section Completed
  17. Phase 4 A Randomized Controlled Trial of Oral Acetaminophen for Analgesic Control After Transvaginal Oocyte Retrieval Completed
  18. Phase 4 Opioid-Free Shoulder Arthroplasty Completed
  19. Phase 4 Multimodal Analgesia With Acetaminophen vs. Narcotics Alone After Hip Arthroscopy Completed
  20. Phase 4 IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty Completed
  21. Phase 4 The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period Completed
  22. Phase 4 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Completed
  23. Phase 4 Acetaminophen (APAP) +/- Oxycodone Completed
  24. Phase 4 Preemptive Analgesia With Celecoxib for Acute Dental Pain Management Completed
  25. Phase 4 Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty Completed
  26. Phase 4 Pre vs Post Block in Total Knee Arthroplasty (TKA) Completed
  27. Phase 4 Efficacy of IV Acetaminophen Versus Oral Acetaminophen Completed
  28. Phase 4 A Prospective Study to Investigate Safety and Tolerability of Shorter Infusion of Fabrazyme Completed
  29. Phase 4 Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain Management Completed
  30. Phase 4 Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures Completed
  31. Phase 4 Effects of a Common Cold Treatment on Cognitive Function Completed
  32. Phase 4 Treatment of Acute Sinusitis Completed
  33. Phase 4 A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies Completed
  34. Phase 4 Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics Completed
  35. Phase 4 Aminotransferase Trends During Prolonged Acetaminophen Dosing Completed
  36. Phase 4 Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days Completed
  37. Phase 4 Time of Intravenous Acetaminophen Administration Completed
  38. Phase 4 A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis Completed
  39. Phase 4 Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever Completed
  40. Phase 4 An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain Completed
  41. Phase 4 Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-menopausal Women With Low Bone Mass Completed
  42. Phase 4 Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13® Completed
  43. Phase 4 Assess the Blood-Oxygen-Level-Dependent (BOLD) Signal Changes in the Brain by Paracetamol as Measured by Functional Magnetic Resonance Imaging (fMRI) in Subjects With Osteoarthritis (OA) Completed
  44. Phase 3 Preoperative Acetaminophen and Carbohydrate Loading Completed

Showing the 50 most-cited and recently-updated of 129 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Proof of concept study uses preSCRIPT framework to annotate prescriptions in UK Biobank
Genetics & Precision Medicine
Proof of concept study uses preSCRIPT framework to annotate prescriptions in UK Biobank preSCRIPT framework identifies genetic links to drug response in UK Biobank
This proof of concept study utilized the preSCRIPT framework to filter and annotate raw prescription data from the UK Biobank, which include…
A proof of concept study in the UK Biobank used preSCRIPT to find genetic links to how people respond to common medications like warfarin an…
medRxiv Apr 30, 2026
Fetal paracetamol exposure linked to reduced ovarian and uterine volume in girls
Pediatrics Cohort
Fetal paracetamol exposure linked to reduced ovarian and uterine volume in girls Prenatal Paracetamol Linked to Smaller Ovaries and Uterus in Girls
This prospective, observational cohort study examined 3425 eligible participants, including 302 girls examined at follow-up.
Prenatal paracetamol exposure is linked to smaller ovaries and uterus in infant girls, raising new questions about long-term reproductive he…
medRxiv Apr 28, 2026
Opioid prescribing in pregnancy increased in Catalonia from 2011 to 2020
Drug Pipeline Cohort
Opioid prescribing in pregnancy increased in Catalonia from 2011 to 2020 Pregnant women getting more pain pills in Spain
This retrospective drug-utilization study of 41,398 pregnancies in Catalonia found that 2.41% involved opioid exposure, with prescribing inc…
A new study shows doctors in Spain are prescribing pain pills to pregnant women more often, but current rules might not be protecting babies…
Frontiers Apr 22, 2026
In silico modeling shows acetaminophen overdose levels affect liver damage sensitivity and metabolic parameters
Drug Pipeline Cohort
In silico modeling shows acetaminophen overdose levels affect liver damage sensitivity and metabolic parameters New computer models predict who is most at risk from acetaminophen overdose
This in silico modeling study evaluated a representative patient cohort exposed to acetaminophen overdose at lower and higher levels.
This research helps us understand why some people suffer worse liver damage from acetaminophen overdose, paving the way for safer drug use.
Frontiers Apr 21, 2026
Paracetamol or ibuprofen treatment outcomes in preterm infants with patent ductus arteriosus: a retrospective cohort analysis
Pediatrics Cohort
Paracetamol or ibuprofen treatment outcomes in preterm infants with patent ductus arteriosus: a retrospective cohort analysis Tiny Hearts, Big Risk: New Clues to a Common Preemie Problem
This retrospective cohort study evaluated pharmacological treatment with intravenous paracetamol or ibuprofen in 60 preterm infants with pat…
For the tiniest premature babies, an open heart passage that doesn't close can be life-threatening, but early treatment helps most infants r…
medRxiv Apr 18, 2026
CBD oil shows no surrogate evidence of drug interactions with opioids or benzodiazepines in advanced cancer patients
Geriatrics & Aging RCT
CBD oil shows no surrogate evidence of drug interactions with opioids or benzodiazepines in advanced cancer patients Study finds CBD oil did not increase side effects when taken with certain cancer medications
A randomized controlled trial in advanced cancer patients found no evidence from surrogate measures that CBD oil increased adverse effects o…
Advanced cancer patients taking CBD oil alongside pain and mental health drugs did not experience increased side effects or drug interaction…
Apr 2, 2026