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Home › Medications › epinephrine

epinephrine

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of epinephrine

30 trials tracked of epinephrine: 18 in phase 3 or 4 and 7 with published results. The most-cited published study has 61 citations.

30Trials tracked
18Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 4 16 Phase 3 2 Phase 2 4 Other / NA 8
  1. Phase 4 Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular Completed · 61 cited
  2. Phase 4 Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension Completed · 60 cited
  3. Phase 4 Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery Completed · 32 cited
  4. Phase 4 Hip Scope Fascia-iliaca (FI) Block Study Completed · 26 cited
  5. Phase 4 Effect of Epinephrine on Post-polypectomy Pain Completed · 15 cited
  6. Phase 4 Perineural Steroids for Peripheral Nerve Blocks Completed · 14 cited
Show 24 more trials
  1. Phase 4 Systemic Steroids for Peripheral Nerve Blocks Completed · 11 cited
  2. Phase 4 Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures Completed
  3. Phase 4 Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty Completed
  4. Phase 4 TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy Completed
  5. Phase 4 A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty Completed
  6. Phase 4 Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus Surgery Completed
  7. Phase 4 Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures Completed
  8. Phase 4 Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP Blocks Completed
  9. Phase 4 Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty Completed
  10. Phase 4 Periarticular Multimodal Drug Injections in Total Knee Arthroplasty Completed
  11. Phase 3 Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis Completed
  12. Phase 3 Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest Completed
  13. Phase 2 M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers Completed
  14. Phase 2 The Prevention of Hypotension After Epidural Analgesia After Major Surgery Completed
  15. Phase 2 Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation Completed
  16. Phase 2 A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis Completed
  17. N/A Decision Support for Intraoperative Low Blood Pressure Completed
  18. N/A Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA) Completed
  19. N/A Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration Completed
  20. N/A Voiding Function After Mid-Urethral Slings With and Without Local Anesthetic: Randomized Controlled Trial Completed
  21. N/A Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients Completed
  22. N/A Conscious Sedation for Epilepsy Surgery Completed
  23. N/A Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis Completed
  24. N/A Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation Completed

Showing the 30 most-cited and recently-updated of 30 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Adding adrenaline to bupivacaine for lipoma plane block reduces blood loss and pain
Oncology RCT
Adding adrenaline to bupivacaine for lipoma plane block reduces blood loss and pain Adrenaline in local blocks reduces pain and bleeding during lipoma surgery
This prospective randomized trial in 40 adults undergoing lipoma excision found that adding adrenaline (1:200,000) to bupivacaine for ultras…
Adding adrenaline to a local anesthetic block lessened pain and bleeding for patients having lipoma removal, based on a trial of 40 adults.
May 1, 2026
De-implementation of low-value bronchiolitis practices showed sustained adherence two years post-trial in a cluster RCT follow-up
Pediatrics RCT
De-implementation of low-value bronchiolitis practices showed sustained adherence two years post-trial in a cluster RCT follow-up Doctors Stick to Better Bronchiolitis Care—2 Years Later
This cluster randomised controlled trial (cRCT) follow-up study assessed the sustainability of de-implementing low-value bronchiolitis pract…
It’s 2 a.m. in a busy children’s hospital.
Apr 22, 2026
AQST-109 sublingual film shows faster time-to-peak concentration than epinephrine autoinjectors in healthy adults
Allergy & Immunology RCT
AQST-109 sublingual film shows faster time-to-peak concentration than epinephrine autoinjectors in healthy adults The Allergy Shot That Goes Under Your Tongue Instead
A phase 3 RCT in healthy adults compared AQST-109 sublingual film to intramuscular epinephrine.
A dissolving film under the tongue delivers epinephrine faster than an EpiPen, offering a needle-free option for severe allergy emergencies.
Apr 14, 2026
A single case report confirms rare IgE-mediated cocoa allergy causing anaphylaxis in a child
Pediatrics Sys. Review
A single case report confirms rare IgE-mediated cocoa allergy causing anaphylaxis in a child Your Child's Chocolate Reaction Might Not Be Milk or Nuts
This systematic review and case report describes a 2-year-old female with a history of allergic rhinitis and tree nut anaphylaxis who experi…
Most chocolate reactions aren't the cocoa itself, but a rare toddler case proves true cocoa allergies exist and require careful testing to f…
Frontiers Apr 14, 2026