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Home › Medications › heparin

heparin

15 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of heparin

15 trials tracked of heparin: 7 in phase 3 or 4 and 3 with published results. The most-cited published study has 45 citations.

15Trials tracked
7Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 2 Phase 3 5 Phase 2 5 Phase 1 1 Other / NA 2
  1. Phase 3 Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection Completed · 45 cited
  2. Phase 3 Prospective Study on Preoperative Versus Postoperative Venous Thromboprophylaxis in Patients Undergoing Major Colorectal Surgery Completed · 36 cited
  3. Phase 3 Assessing Safety, Hospitalization and Efficacy of rNAPc2 in COVID-19 Completed · 12 cited
  4. Phase 4 Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients Completed
  5. Phase 4 Innohep® in Elderly Patients With Impaired Renal Function Treated for Acute Deep Vein Thrombosis Completed
  6. Phase 3 European Ambulance Acute Coronary Syndrome (ACS) Angiography Trial Completed
Show 9 more trials
  1. Phase 3 Study Comparing Desirudin With Heparin to Prevent Vein Clots After Heart and Lung Surgery Completed
  2. Phase 2 Study on Safety and Effectiveness of Three Doses of Argatroban as Anticoagulant in Percutaneous Coronary Intervention (PCI) Completed
  3. Phase 2 t-PA Prophylaxis to Prevent Catheter-associated Thrombosis and Infection Completed
  4. Phase 2 Enriched Heparin Anti COVID-19 Trial Completed
  5. Phase 2 Racial Differences in Vagal Control of Glucose Homeostasis Completed
  6. Phase 2 A Study to Investigate the Effect of Triferic Plus Heparin Infusion Compared to Heparin Alone on Coagulation Parameters in Hemodialysis Patients Completed
  7. Phase 1 Study to Characterize the Effect of Heparin on Palifermin Activity Completed
  8. N/A Effect of Increased Free Fatty Acids on Leptin Function Completed
  9. N/A Using Intravenous Heparin Versus Standard of Care Subcutaneous Heparin to Prevent Clots After Surgery Completed

Showing the 15 most-cited and recently-updated of 15 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Low-dose heparin strategy supports ECMO weaning in pediatric protein S deficiency with pulmonary embolism
Pediatrics Guideline
Low-dose heparin strategy supports ECMO weaning in pediatric protein S deficiency with pulmonary embolism Low Dose Heparin Strategy Helps Child with Pulmonary Embolism
This is a single case report describing a pediatric patient with protein S deficiency and acute pulmonary embolism who was managed with an i…
A specialized heparin strategy helped a child with a rare blood condition successfully recover from a life-threatening blood clot in the lun…
Frontiers Oct 24, 2026
Heparin Shows No Mortality Benefit in Sepsis Meta-Analysis of 426 Patients
Drug Pipeline Meta-analysis
Heparin Shows No Mortality Benefit in Sepsis Meta-Analysis of 426 Patients Heparin treatment shows mixed results for patients with sepsis
This meta-analysis examined heparin use in critically ill patients with sepsis, pooling data from 426 patients. No significant mortality red…
New data on heparin for sepsis shows it does not significantly reduce death rates, and its role in blood clotting remains unclear.
Frontiers Oct 12, 2026
Bivalirudin reduces in-hospital major bleeding and 30-day mortality in patients with acute coronary syndrome
Cardiology Meta-analysis
Bivalirudin reduces in-hospital major bleeding and 30-day mortality in patients with acute coronary syndrome Bivalirudin shows lower bleeding risks than heparin for heart patients
This meta-analysis of 584,249 patients with acute coronary syndrome undergoing percutaneous coronary intervention found that bivalirudin sig…
A large analysis suggests bivalirudin may reduce major bleeding and mortality in patients undergoing procedures for acute coronary syndrome.
NEJM Sep 27, 2026
Local cooling techniques reduce immediate pain after subcutaneous heparin injection with SMD -0.64
Hematology Meta-analysis
Local cooling techniques reduce immediate pain after subcutaneous heparin injection with SMD -0.64 Cooling Techniques May Reduce Pain From Heparin Injections
This meta-analysis of randomized controlled trials involving 807 participants found that local physical cooling techniques reduced immediate…
Local cooling techniques like ice packs or cold sprays may reduce immediate pain and bruising after heparin injections.
Frontiers Aug 11, 2026
Heparinized saline flush associated with higher risk of multiple and bilateral embolic lesions
Radiology & Imaging RCT
Heparinized saline flush associated with higher risk of multiple and bilateral embolic lesions Heparin flush methods linked to more complex brain lesion patterns
This secondary analysis of a randomized controlled trial evaluated 456 patients undergoing transradial cerebral angiography. The study found…
A new look at heart and brain procedures shows that certain heparin flushing techniques may lead to more widespread brain tissue damage.
Aug 6, 2026
Intravesical aminoglycoside instillations reduce recurrent urinary tract infection risk with an IRR of 0.23
Infectious Disease Meta-analysis
Intravesical aminoglycoside instillations reduce recurrent urinary tract infection risk with an IRR of 0.23 New findings show ways to reduce recurring urinary tract infections
This systematic review and meta-analysis of 25 studies evaluates intravesical instillations for preventing recurrent urinary tract infection…
Doctors are looking at new ways to stop repeat urinary tract infections using local treatments like aminoglycosides or hyaluronic acid.
Jul 25, 2026
LMWH remains useful when oral anticoagulants are difficult to use safely in venous thromboembolism patients
Drug Pipeline Sys. Review
LMWH remains useful when oral anticoagulants are difficult to use safely in venous thromboembolism patients Low-molecular-weight heparin remains useful when oral anticoagulants are difficult to use safely
This narrative review examines low-molecular-weight heparin dosing, anti-factor Xa monitoring, treatment interruption, and switching strateg…
A review suggests low-molecular-weight heparin stays useful when oral anticoagulants are difficult to use safely for patients with venous th…
Frontiers Jun 5, 2026
Prehospital unfractionated heparin bolus improved TIMI flow in STEMI without increasing bleeding risk
Cardiology RCT
Prehospital unfractionated heparin bolus improved TIMI flow in STEMI without increasing bleeding risk Pretreatment with UFH improves artery flow for STEMI patients without extra bleeding risk
This single-center randomized trial evaluated pretreatment with unfractionated heparin in patients with ST-segment-elevation myocardial infa…
Giving unfractionated heparin early at first medical contact improved artery flow in heart attack patients without increasing bleeding risk.
May 19, 2026
Meta-analysis shows systemic heparinization reduces early patency loss in adult AVF or graft placement
Nephrology Meta-analysis
Meta-analysis shows systemic heparinization reduces early patency loss in adult AVF or graft placement Systemic heparin lowers early clot risk but raises bleeding danger for arm access patients
This meta-analysis evaluated systemic heparinization versus standard care in adults undergoing arm arteriovenous fistula or graft placement.
A large analysis shows systemic heparin cuts early clot risk for arm access but increases bleeding complications, requiring careful balance.
May 1, 2026
Saudi Arabia study finds most insulin and anticoagulant errors occur during prescribing
Drug Pipeline Cohort
Saudi Arabia study finds most insulin and anticoagulant errors occur during prescribing Insulin and Blood Thinners Behind Thousands of Drug Errors
This retrospective observational real-world study analyzed 63,817 medication error reports from Saudi Arabia involving adults (>18 years).
Insulin and blood thinners caused most of the 63,817 drug errors reported in Saudi Arabia between 2020 and 2023, with pharmacists catching t…
Frontiers Apr 19, 2026
Protocol outlines individualized anticoagulation monitoring in critically ill adults using unfractionated or low-molecular-weight heparin
Rheumatology Cohort
Protocol outlines individualized anticoagulation monitoring in critically ill adults using unfractionated or low-molecular-weight heparin ICU Blood Clot Prevention Has a Monitoring Problem — This Study Aims to Fix It
This study protocol describes a prospective observational cohort design evaluating individualized anticoagulation monitoring in critically i…
A new prospective study is testing whether a real-time clotting test called viscoelastic testing can give ICU doctors a more complete pictur…
Frontiers Apr 18, 2026
Observational study identifies PF4-dependent antibodies in ELISA-negative HIT patients via functional testing
Hematology
Observational study identifies PF4-dependent antibodies in ELISA-negative HIT patients via functional testing Could stopping blood thinners because of a false negative test actually harm you?
This observational research article with an animal component evaluates PF4-dependent platelet-activating antibodies in ELISA-negative patien…
Standard blood tests for a dangerous clotting disorder missed six patients, leading doctors to stop life-saving medicine and causing new clo…
medRxiv Apr 18, 2026

All heparin Articles