Baricitinib showed limited efficacy in pediatric JIA-uveitis patients refractory to methotrexate or biologics at week 24
New Hope for Kids with Stubborn Eye Inflammation
This open-label, active-controlled phase-3 multicenter trial enrolled 30 pediatric patients with juvenile idiopathic arthritis-associated uv…
A new drug shows early promise for children with stubborn eye inflammation who didn't respond to standard treatments, offering hope when oth…
Sudden sensorineural hearing loss risk factors in ankylosing spondylitis patients on adalimumab plus methotrexate
Could long-term arthritis treatment raise your risk of sudden hearing loss?
This retrospective case-control analysis drew on 2,564 ankylosing spondylitis patients at Henan Provincial People's Hospital (2015-2024), co…
Patients with long-term ankylosing spondylitis taking adalimumab and methotrexate are more likely to experience sudden hearing loss than tho…
Oral tofacitinib monotherapy with fire needling induced marked regression of cutaneous Rosai-Dorfman disease lesions in a single patient
A pill and a heated needle tamed a stubborn face disease
This case report and literature review describes a 55-year-old female with refractory cutaneous Rosai-Dorfman disease who failed prior thera…
A woman whose face was covered in stubborn red nodules finally saw improvement when doctors tried a surprising combination that crossed medi…
Interstitial lung disease reduces achievement of rheumatoid arthritis treatment goals over 24 months
Why Interstitial Lung Disease Blocks Rheumatoid Arthritis Goals
This retrospective cohort study examined 254 patients with newly diagnosed rheumatoid arthritis who underwent chest CT within one year of on…
Rheumatoid arthritis treatments often fail to reach pain-free goals when the disease also attacks the lungs, making standard care harder for…
Biological DMARDs show marginal patient-reported outcome benefits over conventional therapy in early rheumatoid arthritis
Early rheumatoid arthritis patients report similar symptom relief with different treatment approaches
This open-label randomized trial in 795 newly diagnosed, DMARD-naïve RA patients compared three biological DMARDs plus methotrexate against …
In early rheumatoid arthritis, patients reported similar pain relief and quality-of-life improvements whether they started with conventional…
Post-hoc analysis of RCTs and cohorts identifies predictors of remission in ACPA-positive early RA treated with abatacept plus methotrexate or methotrexate alone
Early disease activity and response predict remission in ACPA-positive rheumatoid arthritis patients
This post-hoc analysis of randomized controlled trials and an observational cohort evaluated predictors of DAS28-CRP remission in ACPA-posit…
Only early disease activity and treatment response predict remission in ACPA-positive rheumatoid arthritis, while genetic markers and imagin…
Case report: Orelabrutinib-rituximab with intravitreal methotrexate shows response in primary vitreoretinal lymphoma
Can a new drug combination help treat a rare eye cancer?
A case report with literature review describes one patient with primary vitreoretinal lymphoma (PVRL) treated with orelabrutinib and rituxim…
A new drug combination improved vision and controlled tumors in a patient with a rare eye cancer, with no reported side effects.
Machine learning model predicts delayed methotrexate clearance in pediatric osteosarcoma patients
Study develops model to predict delayed drug clearance in pediatric bone cancer
A retrospective cohort study of 181 pediatric osteosarcoma patients treated with high-dose methotrexate developed a web-based prediction mod…
A new computer model predicts which children with bone cancer face delayed drug clearance, helping doctors monitor treatment risks before co…
FPGS Gene Variants Linked to Methotrexate Efficacy and Toxicity in Rheumatoid Arthritis
Could your genes explain why methotrexate works better for some people?
A meta-analysis of 2345 rheumatoid arthritis patients on methotrexate found FPGS polymorphisms rs10106 and rs1544105 were significantly asso…
Your genes might explain why methotrexate works better for some rheumatoid arthritis patients but also raises their risk of harmful side eff…
Case report tracks urinary ADEV GluN1 levels in anti-NMDAR encephalitis patient during treatment
Single case study tracks brain inflammation marker in urine during treatment
A case report of a single female patient with anti-NMDAR encephalitis analyzed urinary astrocyte-derived extracellular vesicles (ADEVs).
Urine tests tracked brain inflammation changes in a patient with anti-NMDAR encephalitis, showing protein levels dropped over treatment and …
Meta-analysis finds nausea in 24% and abdominal pain in 20% of RA patients on methotrexate
How common is nausea and stomach pain for RA patients on methotrexate?
A systematic review and meta-analysis of 37 studies involving 19,986 adult RA patients on methotrexate found pooled prevalence rates of 24.3…
Nearly one in five rheumatoid arthritis patients taking methotrexate experience nausea or stomach pain, with about 8.5% stopping the drug du…