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Home › Medications › methotrexate

methotrexate

23 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of methotrexate

313 trials tracked of methotrexate: 155 in phase 3 or 4 and 68 with published results. The most-cited published study has 1687 citations.

313Trials tracked
155Phase 3 & 4
0Recruiting
68With published results
Phase distribution
Phase 4 42 Phase 3 113 Phase 2 137 Phase 1 10 Other / NA 11
  1. Phase 3 Pembrolizumab (MK-3475) Versus Standard Treatment for Recurrent or Metastatic Head and Neck Cancer (MK-3475-040/KEYNOTE-040) Completed · 1,687 cited
  2. Phase 3 Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Head and Neck Carcinoma (CheckMate 141) Completed · 799 cited
  3. Phase 4 Mechanism of Action Study for Psoriasis Completed · 721 cited
  4. Phase 3 A Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Participants With CD30-Positive Cutaneous T-Cell Lymphoma (ALCANZA Study) Completed · 579 cited
  5. Phase 3 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Completed · 535 cited
  6. Phase 3 TAC/MTX vs. TAC/MMF/PTCY for Prevention of Graft-versus-Host Disease and Microbiome and Immune Reconstitution Study (BMT CTN 1703/1801) Completed · 535 cited
Show 44 more trials
  1. Phase 3 Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL) Completed · 322 cited
  2. Phase 3 Evaluation of Sarilumab (SAR153191/REGN88) on Top of Methotrexate in Rheumatoid Arthritis Patients Completed · 269 cited
  3. Phase 3 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 248 cited
  4. Phase 3 05-001: Treatment of Acute Lymphoblastic Leukemia in Children Completed · 238 cited
  5. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 226 cited
  6. Phase 3 Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission Completed · 223 cited
  7. Phase 3 Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis Completed · 216 cited
  8. Phase 3 To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET) Completed · 209 cited
  9. Phase 4 Study to Assess the Short- and Long-term Efficacy of Certolizumab Pegol Plus Methotrexate Compared to Adalimumab Plus Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis (RA) Inadequately Responding to Methotrexate Completed · 179 cited
  10. Phase 3 Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301) Completed · 167 cited
  11. Phase 3 A Study in Moderate to Severe Rheumatoid Arthritis Completed · 158 cited
  12. Phase 3 A Study in Participants With Moderate to Severe Rheumatoid Arthritis Completed · 158 cited
  13. Phase 4 Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid Arthritis Completed · 157 cited
  14. Phase 3 A Double Blind Study in Pediatric Subjects With Chronic Plaque Psoriasis, Studying Adalimumab vs. Methotrexate Completed · 148 cited
  15. Phase 4 MTX Discontinuation and Vaccine Response Completed · 138 cited
  16. Phase 3 An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA) Completed · 131 cited
  17. Phase 3 A Study to Evaluate Efficacy and Safety of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to Methotrexate (MTX) Treatment Completed · 129 cited
  18. Phase 4 Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis. Completed · 128 cited
  19. Phase 3 To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN) Completed · 124 cited
  20. Phase 3 A Study to Evaluate the Safety and Efficacy of MabThera (Rituximab) in Combination With Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Who Failed on Anti-Tumor Necrosis Factor Alpha Therapy Completed · 105 cited
  21. Phase 3 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Completed · 100 cited
  22. Phase 4 Triple Combination Therapy in High Risk Crohn's Disease (CD) Completed · 87 cited
  23. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Completed · 84 cited
  24. Phase 4 Treatments Against RA and Effect on FDG-PET/CT Completed · 73 cited
  25. Phase 4 IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA Completed · 70 cited
  26. Phase 4 Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout Completed · 65 cited
  27. Phase 3 Efficacy of Golimumab in Combination With Methotrexate (MTX) Versus MTX Monotherapy, in Improving Dactylitis, in MTX naïve Psoriatic Arthritis Patients Completed · 62 cited
  28. Phase 3 LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy Completed · 58 cited
  29. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed · 57 cited
  30. Phase 4 Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout Completed · 54 cited
  31. Phase 4 Study to Assess Changes in the Immune Profile in Adults With Early Rheumatoid Arthritis Completed · 51 cited
  32. Phase 3 A Study of Tocilizumab and Methotrexate in Combination or as Monotherapy in Treatment-Naïve Patients With Early Rheumatoid Arthritis Completed · 51 cited
  33. Phase 3 A Study to Compare Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have Not Previously Taken Methotrexate Completed · 51 cited
  34. Phase 3 A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY) Completed · 51 cited
  35. Phase 3 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Completed · 50 cited
  36. Phase 3 A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous (SC) Tocilizumab (TCZ) With MTX Completed · 50 cited
  37. Phase 3 Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Completed · 48 cited
  38. Phase 3 A Study Assessing the Efficacy and Safety of Sarilumab Added to MTX in Japanese Patients With Moderately to Severely Active Rheumatoid Arthritis (SARIL-RA-KAKEHASI) Completed · 46 cited
  39. Phase 3 Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed · 46 cited
  40. Phase 3 A Study of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque Psoriasis Naive to Systemic Treatment Completed · 43 cited
  41. Phase 3 Open-Label Extension Study Of Tofacitinib In Psoriatic Arthritis Completed · 41 cited
  42. Phase 3 Low Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) Therapy Completed · 40 cited
  43. Phase 3 A Study on Safety and Efficacy of Tocilizumab (RoActemra/Actemra) Alone or in Combination With Non-Biologic Antirheumatics in Participants With Rheumatoid Arthritis Completed · 37 cited
  44. Phase 3 A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent Completed · 37 cited

Showing the 50 most-cited and recently-updated of 313 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Short-term prednisolone bridging enables 95% discontinuation in new rheumatoid arthritis patients after 24 months
Rheumatology RCT
Short-term prednisolone bridging enables 95% discontinuation in new rheumatoid arthritis patients after 24 months Most patients stop steroid use after a short bridge to methotrexate treatment
This randomized controlled trial enrolled 230 patients with newly diagnosed rheumatoid arthritis naive to disease-modifying antirheumatic dr…
A trial of 230 patients with new rheumatoid arthritis found that most could stop using prednisolone after just seven weeks of short-term bri…
Jun 5, 2026
Review discusses pharmacogenomic biomarkers for pediatric B-ALL chemotherapy dosing
Drug Pipeline Sys. Review
Review discusses pharmacogenomic biomarkers for pediatric B-ALL chemotherapy dosing New review looks at using genetic tests to adjust cancer drug doses for kids
This narrative review examines the role of pharmacogenomic biomarkers and genotype-guided dose adjustments in pediatric B-cell acute lymphob…
A recent review suggests that checking specific genes before treatment can help doctors give the right amount of chemotherapy to children wi…
Frontiers May 24, 2026
Systematic review of intrathecal therapy for leptomeningeal metastasis in non-small cell lung cancer
Drug Pipeline Meta-analysis
Systematic review of intrathecal therapy for leptomeningeal metastasis in non-small cell lung cancer Intrathecal therapy may help some lung cancer patients with brain lining spread
This systematic review evaluates intrathecal therapy for adult patients with NSCLC-related leptomeningeal metastasis using ten original stud…
A review of ten studies suggests intrathecal therapy can improve symptoms and clear cancer cells from spinal fluid for some lung cancer pati…
Frontiers May 20, 2026
Living systematic review finds low-certainty evidence that stopping csDMARDs before surgery may increase flare risk in inflammatory arthritis
Allergy & Immunology Sys. Review
Living systematic review finds low-certainty evidence that stopping csDMARDs before surgery may increase flare risk in inflammatory arthritis Stopping arthritis drugs before surgery may raise flare risk
This living systematic review evaluates perioperative management of conventional synthetic DMARDs in adults with rheumatoid arthritis, psori…
Low-certainty evidence suggests stopping certain arthritis drugs before surgery might increase the chance of a disease flare, but infection …
Cochrane May 20, 2026
Systematic review and meta-analysis of herpes zoster risk in rheumatoid arthritis patients
Rheumatology Meta-analysis
Systematic review and meta-analysis of herpes zoster risk in rheumatoid arthritis patients Rheumatoid Arthritis Patients Face Higher Shingles Risk Than General Public
This systematic review and meta-analysis synthesized data on herpes zoster risk in rheumatoid arthritis patients. The pooled proportion of h…
People with rheumatoid arthritis have a much higher chance of getting shingles, and doctors must watch for specific risk factors like high s…
Frontiers May 9, 2026
Narrative review of treatment strategies for primary central nervous system lymphoma
Dermatology Sys. Review
Narrative review of treatment strategies for primary central nervous system lymphoma A Smarter Way to Treat a Rare Brain Lymphoma Is Emerging
This narrative review covers treatment strategies for primary central nervous system lymphoma, including HD-MTX-based regimens, HDC-ASCT, an…
A rare lymphoma hiding in the brain now has sharper risk tools and smarter drug combos that could mean fewer relapses and less toxic treatme…
Frontiers May 8, 2026
Narrative review of transposable element methylation in autoimmune diseases
Diabetes & Endocrinology Sys. Review
Narrative review of transposable element methylation in autoimmune diseases Genetic elements may link autoimmune diseases to inflammation
This narrative review examines the role of transposable element (TE) methylation and expression in Type 1 diabetes, systemic lupus erythemat…
Changes in certain genetic elements could explain how the body triggers inflammation in diseases like lupus and rheumatoid arthritis.
Frontiers May 1, 2026
Systematic review and meta-analysis supports adalimumab plus methotrexate for JIA-associated uveitis
Pediatrics Meta-analysis
Systematic review and meta-analysis supports adalimumab plus methotrexate for JIA-associated uveitis Combination therapy reduces relapse risk in children with eye inflammation from arthritis
This systematic review and meta-analysis of RCTs evaluated adalimumab plus methotrexate in children with juvenile idiopathic arthritis-assoc…
Combining adalimumab with methotrexate lowers relapse risk and helps reduce steroid use in children with arthritis-related eye inflammation.
May 1, 2026
PD-L1-armored CAR-T followed by allo-HSCT yields 7-year remission in refractory B-cell ALL
Allergy & Immunology Cohort
PD-L1-armored CAR-T followed by allo-HSCT yields 7-year remission in refractory B-cell ALL New Leukemia Treatment Keeps Adult Patient Cancer Free For Seven Years
This retrospective observational analysis of a single clinical case describes an adult patient with early-relapsed, chemorefractory B-cell a…
A new dual-targeted therapy helped an adult with tough leukemia stay cancer-free for seven years after standard treatments failed.
Frontiers Apr 27, 2026
Case Report Describes Treatment of Severe Mosquito Bite Allergy and EBV-Associated NK-Cell Lymphoproliferative Disorder
Allergy & Immunology Sys. Review
Case Report Describes Treatment of Severe Mosquito Bite Allergy and EBV-Associated NK-Cell Lymphoproliferative Disorder Why a 70-Year-Old Man’s Mosquito Bites Turned Deadly
This case report details the clinical management of a 70-year-old male with severe mosquito bite allergy and EBV-associated NK-cell lymphopr…
A single mosquito bite can sometimes signal a hidden immune problem, especially in older adults.
Frontiers Apr 23, 2026
Combined Therapy for Febrile Ulceronecrotic Mucha-Habermann Disease in Young Children: Case Report and Review
Pediatrics Sys. Review
Combined Therapy for Febrile Ulceronecrotic Mucha-Habermann Disease in Young Children: Case Report and Review Doctors Heal Rare Skin Condition in Toddler Using Drug Combo
This publication is a case report and literature review focusing on Febrile ulceronecrotic Mucha-Habermann disease in preschool-aged childre…
A rare and painful skin disease in young children may now have a clearer path to recovery.
Frontiers Apr 23, 2026
Systematic Review and Network Meta-Analysis Compares Enteral Nutrition and Medications in Pediatric Crohn's Disease
Pediatrics Meta-analysis
Systematic Review and Network Meta-Analysis Compares Enteral Nutrition and Medications in Pediatric Crohn's Disease Exclusive nutrition therapy beats steroids for healing Crohn's in kids
This systematic review and network meta-analysis evaluates enteral nutrition versus immunomodulators and corticosteroids in 1,182 pediatric …
Exclusive nutrition therapy was far better than steroids at healing Crohn's disease in children, with fewer side effects and no serious risk…
Frontiers Apr 22, 2026

All methotrexate Articles