HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Drug Pipeline
Meta-analysis
Intrathecal chemotherapy provides objective response rates of 34.5% to 86.4% in non-small-cell lung cancer leptomeningeal metastasis
Intrathecal chemotherapy shows promise for lung cancer spreading to brain
This systematic review evaluates intrathecal chemotherapy for patients with leptomeningeal metastasis of non-small-cell lung cancer. The syn…
New data shows that delivering chemotherapy directly into the spinal fluid can help patients with lung cancer that has spread to the lining …
Frontiers
Jun 30, 2026
Oncology
Meta-analysis
Intrathecal chemotherapy via Ommaya reservoir improves survival in leptomeningeal metastasis
Ommaya reservoirs may help patients with leptomeningeal metastasis live longer than lumbar punctures
This systematic review and meta-analysis of four comparative studies found that intrathecal chemotherapy via Ommaya reservoir was associated…
A new analysis suggests Ommaya reservoirs improve survival and lower side effects for patients with leptomeningeal metastasis compared to lu…
Jun 6, 2026
Neurology
Guideline
Narrative review outlines multimodal decision-making for EGFR-mutant NSCLC with leptomeningeal metastasis
Doctors outline a pathway for treating lung cancer that spreads to the brain
This narrative review addresses patients with EGFR-mutant non-small cell lung cancer who develop resistance to tyrosine kinase inhibitors an…
This review outlines a clinical pathway to help physicians personalize treatment for lung cancer patients with brain spread.
Frontiers
May 21, 2026
Drug Pipeline
Meta-analysis
Systematic review of intrathecal therapy for leptomeningeal metastasis in non-small cell lung cancer
Intrathecal therapy may help some lung cancer patients with brain lining spread
This systematic review evaluates intrathecal therapy for adult patients with NSCLC-related leptomeningeal metastasis using ten original stud…
A review of ten studies suggests intrathecal therapy can improve symptoms and clear cancer cells from spinal fluid for some lung cancer pati…
Frontiers
May 20, 2026