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Home › Medications › nicotine replacement therapy

nicotine replacement therapy

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of nicotine replacement therapy

21 trials tracked of nicotine replacement therapy: 10 in phase 3 or 4 and 4 with published results. The most-cited published study has 37 citations.

21Trials tracked
10Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 8 Phase 3 2 Phase 2 3 Phase 1 1 Other / NA 7
  1. Phase 4 Changing the Default for Tobacco Treatment Completed · 37 cited
  2. Phase 3 Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers Completed · 30 cited
  3. Phase 4 Post-Discharge Smoking Cessation Strategies: Helping HAND 4 Completed · 24 cited
  4. Phase 4 Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers Completed · 4 cited
  5. Phase 4 A Smoking Cessation Intervention for Yale Dining Employees Completed
  6. Phase 4 Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia Completed
Show 15 more trials
  1. Phase 4 Tobacco Use Treatment in Cancer Patients Completed
  2. Phase 4 Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH) Completed
  3. Phase 4 Testing Integrative Smoking Cessation for HIV Patients Completed
  4. Phase 3 Metabolism Informed Smoking Treatment: The MIST RCT Completed
  5. Phase 2 A Pilot Study Evaluating Nicotine Lozenges and Self Help Completed
  6. Phase 2 Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence Completed
  7. Phase 2 Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties Completed
  8. Phase 1 Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine Completed
  9. N/A Mindfulness-based Smoking Cessation Enhanced With Mobile Technology Completed
  10. N/A Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP) Completed
  11. N/A Financial Incentives for Smoking Cessation Among Mothers Completed
  12. N/A Acceptability of Less Harmful Alternatives to Cigarettes Completed
  13. N/A Stop Smoking Therapy for Ontario Patients Completed
  14. N/A Preventing Weight Gain and Controlling Blood Pressure During Smoking Cessation in Hypertensive Smokers Completed
  15. N/A Smoking Cessation Using Motivational Therapy and Varenicline Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Early assessment at 4 weeks versus 8 weeks increases abstinence odds in tobacco users
Pulmonology & Critical Care RCT
Early assessment at 4 weeks versus 8 weeks increases abstinence odds in tobacco users Early Assessment May Improve Success Rates for Quitting Smoking
This randomized controlled trial of 636 daily smokers eligible for lung cancer screening found that a 4-week assessment interval was associa…
Checking progress at 4 weeks instead of 8 weeks may help people who smoke daily successfully quit using nicotine replacement therapy.
Jul 24, 2026
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
Infectious Disease RCT
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
May 1, 2026
Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality
Cardiology Cohort
Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality Adding Prescription Meds to Nicotine Patches Lowers Heart Death Risk
This retrospective cohort study of 8,574 propensity-matched pairs found that adding bupropion or varenicline to NRT after ACS was associated…
Heart attack survivors who quit smoking with extra prescription help live longer.
medRxiv Apr 24, 2026