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Home › Medications › nicotine replacement therapy

nicotine replacement therapy

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of nicotine replacement therapy

21 trials tracked of nicotine replacement therapy: 10 in phase 3 or 4 and 4 with published results. The most-cited published study has 41 citations.

21Trials tracked
10Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 8 Phase 3 2 Phase 2 3 Phase 1 1 Other / NA 7
  1. Phase 4 Changing the Default for Tobacco Treatment Completed · 41 cited
  2. Phase 3 Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers Completed · 30 cited
  3. Phase 4 Post-Discharge Smoking Cessation Strategies: Helping HAND 4 Completed · 24 cited
  4. Phase 4 Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers Completed · 4 cited
  5. Phase 4 A Smoking Cessation Intervention for Yale Dining Employees Completed
  6. Phase 4 Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia Completed
Show 15 more trials
  1. Phase 4 Tobacco Use Treatment in Cancer Patients Completed
  2. Phase 4 Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH) Completed
  3. Phase 4 Testing Integrative Smoking Cessation for HIV Patients Completed
  4. Phase 3 Metabolism Informed Smoking Treatment: The MIST RCT Completed
  5. Phase 2 A Pilot Study Evaluating Nicotine Lozenges and Self Help Completed
  6. Phase 2 Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence Completed
  7. Phase 2 Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties Completed
  8. Phase 1 Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine Completed
  9. N/A Mindfulness-based Smoking Cessation Enhanced With Mobile Technology Completed
  10. N/A Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP) Completed
  11. N/A Financial Incentives for Smoking Cessation Among Mothers Completed
  12. N/A Acceptability of Less Harmful Alternatives to Cigarettes Completed
  13. N/A Stop Smoking Therapy for Ontario Patients Completed
  14. N/A Preventing Weight Gain and Controlling Blood Pressure During Smoking Cessation in Hypertensive Smokers Completed
  15. N/A Smoking Cessation Using Motivational Therapy and Varenicline Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Smoking Cessation Aids Parents of Chronically Ill Children
Pediatrics Meta-analysis
Smoking Cessation Aids Parents of Chronically Ill Children Smoking Cessation Programs Show Mixed Results for Parents of Children
Meta-analysis finds counseling boosts short-term quit rates in parents of children with chronic disease, but effects fade.
New data shows that while some smoking cessation programs help parents quit for a short time, they do not always reduce a child's exposure t…
Sep 8, 2026
Virtual sustained treatment increases 6-month abstinence rates to 28.4% compared to 14.7% in cancer patients
Oncology RCT
Virtual sustained treatment increases 6-month abstinence rates to 28.4% compared to 14.7% in cancer patients Virtual counseling and nicotine therapy help cancer patients quit smoking
This randomized controlled trial of 306 English- and Spanish-speaking cancer patients found that virtual sustained treatment (VST) significa…
A new trial shows that virtual coaching combined with nicotine replacement helps significantly more cancer patients quit smoking than standa…
Aug 22, 2026
Personalised CT feedback fails to boost quit rates overall in lung cancer screening
Pulmonology & Critical Care RCT
Personalised CT feedback fails to boost quit rates overall in lung cancer screening Personalized images of lung damage do not increase smoking quit rates
In a randomized controlled trial of 1003 individuals attending lung cancer screening, a personalised smoking cessation package with annotate…
Showing patients their own lung scans does not improve overall smoking quit rates, though it may show different results for women.
Aug 15, 2026
HMA plus NRT protocol aims to reduce nicotine craving and boost abstinence in TUD
Primary Care & Family Medicine RCT
HMA plus NRT protocol aims to reduce nicotine craving and boost abstinence in TUD New Trial to Test Acupuncture for Smoking Cessation
This randomized controlled trial protocol will compare harmonizing mind acupuncture plus nicotine replacement therapy against nicotine repla…
A new trial will test if adding acupuncture to nicotine patches helps people quit smoking and curb cravings.
Frontiers Aug 7, 2026
Early assessment at 4 weeks versus 8 weeks increases abstinence odds in tobacco users
Pulmonology & Critical Care RCT
Early assessment at 4 weeks versus 8 weeks increases abstinence odds in tobacco users Early Assessment May Improve Success Rates for Quitting Smoking
This randomized controlled trial of 636 daily smokers eligible for lung cancer screening found that a 4-week assessment interval was associa…
Checking progress at 4 weeks instead of 8 weeks may help people who smoke daily successfully quit using nicotine replacement therapy.
Jul 24, 2026
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
Infectious Disease RCT
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
May 1, 2026
Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality
Cardiology Cohort
Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality Adding Prescription Meds to Nicotine Patches Lowers Heart Death Risk
This retrospective cohort study of 8,574 propensity-matched pairs found that adding bupropion or varenicline to NRT after ACS was associated…
Heart attack survivors who quit smoking with extra prescription help live longer.
medRxiv Apr 24, 2026