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Home › Medications › Saline

Saline

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of Saline

144 trials tracked of Saline: 65 in phase 3 or 4 and 26 with published results. The most-cited published study has 306 citations.

144Trials tracked
65Phase 3 & 4
0Recruiting
26With published results
Phase distribution
Phase 4 46 Phase 3 19 Phase 2 39 Phase 1 11 Other / NA 29
  1. Phase 3 Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP Completed · 306 cited
  2. Phase 3 Convalescent Plasma in Outpatients With COVID-19 Completed · 210 cited
  3. Phase 4 Adding Liraglutide to High Dose Insulin: Breaking the Cycle Completed · 73 cited
  4. Phase 3 A Trial to Assess the Lot Consistency, Safety, Tolerability and Immunogenicity of Bivalent rLP2086 Vaccine When Given to Healthy Subjects Aged ≥10 to <19 Years Completed · 71 cited
  5. Phase 4 Genicular Nerve Block for Total Knee Arthroplasty Completed · 51 cited
  6. Phase 4 Sonographic Hysterosalpingography: Oil vs Water Based Media (SHOW Trial) Completed · 47 cited
Show 44 more trials
  1. Phase 4 Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women Completed · 43 cited
  2. Phase 3 Intravenous Thyroxine for Heart-Eligible Organ Donors Completed · 42 cited
  3. Phase 4 Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen Completed · 40 cited
  4. Phase 4 Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery Completed · 36 cited
  5. Phase 4 Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy Completed · 26 cited
  6. Phase 4 Determine the Clinical Advantage of IV vs PO Acetaminophen Completed · 21 cited
  7. Phase 4 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Completed · 21 cited
  8. Phase 3 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Completed · 21 cited
  9. Phase 3 Black Widow Spider Antivenin for Patients With Systemic Latrodectism Completed · 18 cited
  10. Phase 4 Femoral Peri-arterial Local Anesthetic Injection Decreases Tourniquet Associated Ischemic Hypertension Completed · 17 cited
  11. Phase 3 A Trial to Describe the Immunogenicity and Safety of 2 Doses of Bivalent rLP2086 (Trumenba) and a Pentavalent Meningococcal Vaccine in Healthy Subjects >=10 to <26 Years of Age. Completed · 17 cited
  12. Phase 4 Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus Surgery Completed · 15 cited
  13. Phase 4 The Effects of Dexmedetomidine on the Heart Beat During Elective Surgery in Children Completed · 13 cited
  14. Phase 4 Human Fibrinogen Concentrate in Pediatric Cardiac Surgery Completed · 12 cited
  15. Phase 4 Systemic Steroids for Peripheral Nerve Blocks Completed · 11 cited
  16. Phase 3 Endogenous GLP-1 Secretion on Islet Function in People With and Without Type 2 Diabetes Completed · 9 cited
  17. Phase 3 Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda Completed · 7 cited
  18. Phase 3 Using BCG to Protect Senior Citizens During the COVID-19 Pandemic Completed · 7 cited
  19. Phase 4 Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS) Completed · 5 cited
  20. Phase 4 Steroids in Bilateral Total Knee Replacement Completed
  21. Phase 4 Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery Completed
  22. Phase 4 Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection Completed
  23. Phase 4 Intranasal Midazolam for Treatment of Anxiety in Children Undergoing Suturing in the Pediatric Emergency Department Completed
  24. Phase 4 Eovist vs. Dotarem Healthy Volunteer MRI Completed
  25. Phase 4 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed
  26. Phase 4 Bupivacaine Liposomal Injection (Exparel) for Postsurgical Analgesia in Patient Undergoing Laparoscopic Bariatric Surgery Completed
  27. Phase 4 Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration Completed
  28. Phase 4 Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery? Completed
  29. Phase 4 Efficacy of Continuous Infusion Ropivacaine Interscalene Blocks Completed
  30. Phase 4 Effects of Intramuscular Oxytocin on Sensory Function in Healthy Volunteers With Ultraviolet Burn Injury to the Skin Completed
  31. Phase 4 Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty. Completed
  32. Phase 4 Testosterone for Peripheral Vascular Disease Completed
  33. Phase 4 Unilateral TAP Block for Laparoscopic Gastric Sleeve Surgery Completed
  34. Phase 4 Hip Fracture Exparel Administration Trial Capsule During Hemiarthroplasty Completed
  35. Phase 4 Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation Completed
  36. Phase 4 Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal) Completed
  37. Phase 4 Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication Completed
  38. Phase 4 Calcitonin Gene-related Peptide Levels in Chronic Migraine Completed
  39. Phase 4 Intranasal Fentanyl as an Analgesic for Cystoscopic Procedures Completed
  40. Phase 4 Analgesic Benefits of Perineural Versus Intravenous Dexamethasone in Patients Receiving Sciatic Nerve Block Completed
  41. Phase 4 Dexmedetomidine vs Fentanyl for BMT Completed
  42. Phase 4 Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy Completed
  43. Phase 4 Variable Rate Phenylephrine Infusion for Prevention of Spinal-induced Hypotension for Cesarean Delivery Completed
  44. Phase 4 Preventing Propofol-associated Injection Pain Completed

Showing the 50 most-cited and recently-updated of 144 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Intravenous Recombinant Human Plasma Gelsolin Safety and Pharmacokinetics Evaluated in Phase 1 Trial of Healthy Volunteers
Drug Pipeline RCT
Intravenous Recombinant Human Plasma Gelsolin Safety and Pharmacokinetics Evaluated in Phase 1 Trial of Healthy Volunteers Can this new IV drug be safely given? Early results show mild effects
This Phase 1 randomized controlled trial evaluated the safety and pharmacokinetics of intravenous recombinant human plasma gelsolin in 32 he…
A new IV drug caused only mild side effects in healthy volunteers, but doctors must wait for more data before using it to treat sick patient…
medRxiv Apr 19, 2026
Phase 1 cohort study assesses prophylactic pDNA vaccine safety and immunogenicity in healthy adults
Infectious Disease Cohort
Phase 1 cohort study assesses prophylactic pDNA vaccine safety and immunogenicity in healthy adults Early study of a COVID-19 DNA vaccine in healthy adults showed no serious safety issues
This Phase 1 cohort study enrolled 42 eligible healthy subjects to evaluate a prophylactic COVID-19 pDNA vaccine compared to placebo (Saline…
A new COVID-19 DNA vaccine showed no serious safety issues in healthy adults after six months of monitoring.
Frontiers Apr 17, 2026