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Drug Pipeline
Cohort
Prospective observational study identifies 2,504 potential drug-drug interactions among hospitalized patients with acute coronary syndrome.
Heart Patients Face Hidden Risks From Common Drug Mixes
This prospective observational cohort study evaluated 371 hospitalized patients with acute coronary syndrome at Assiut University Heart Hosp…
Taking several heart medications at once can create dangerous hidden interactions that increase the risk of treatment failure and hospital s…
Frontiers
Apr 19, 2026
Cardiology
RCT
Ticagrelor Not Noninferior to Prasugrel in Diabetes Patients With Multivessel CAD After PCI
New study shows ticagrelor did not beat prasugrel for heart attack prevention in diabetics
This randomized clinical trial of 1,800 patients with diabetes and multivessel coronary artery disease undergoing PCI compared ticagrelor pl…
For diabetics with heart stents, a new study found ticagrelor offered no clear advantage over prasugrel in preventing death, heart attacks, …
JAMA Cardiol
Apr 9, 2026
Cardiology
RCT
Adding low-dose rivaroxaban to DAPT did not significantly reduce LV thrombus in anterior STEMI patients.
Adding low-dose rivaroxaban to standard heart attack drugs did not clearly prevent blood clots in the heart
This randomized clinical trial evaluated 560 patients with anterior ST-segment elevation myocardial infarction (STEMI) across 29 centers in …
Adding a low-dose blood thinner to standard heart attack drugs did not clearly prevent dangerous clots in the heart, based on a trial of 560…
JAMA Cardiol
Apr 9, 2026
Neurology
RCT
Lp-PLA2 activity does not significantly modify dual antiplatelet therapy efficacy in minor stroke/TIA with CYP2C19 loss-of-function alleles
Blood enzyme levels don't change which stroke prevention drug works better, study finds
This subgroup analysis of the CHANCE-2 RCT examined 5919 patients with minor stroke/TIA and CYP2C19 loss-of-function alleles. Lp-PLA2 activi…
A simple blood test for inflammation doesn't predict which stroke prevention drug works best for patients with a specific genetic trait.
Apr 5, 2026
Cardiology
Phase II
Phase 2 pilot study evaluates ticagrelor monotherapy safety after stenting for acute MI
Can a single blood thinner prevent heart attacks after stent placement?
A single-center, single-arm, prospective phase II pilot study of 200 patients assessed the initial safety of ticagrelor monotherapy after co…
A new pilot study tests if one blood thinner alone can safely prevent heart attacks and stent clots after stent placement for heart attack p…
CT.gov
Mar 30, 2026
Cardiology
Meta-analysis
Early Aspirin Withdrawal Post-PCI Reduces Bleeding, No MI Increase with P2Y12 Monotherapy
Could Stopping Aspirin Early Help Heart Patients Avoid Bleeding Risks?
Meta-analysis shows early aspirin withdrawal (≤3 months) post-PCI with ticagrelor/prasugrel reduces bleeding (HR=0.55, 95% CI [0.42, 0.71]; …
Stopping aspirin within three months after a heart procedure reduces bleeding risk without increasing heart attack chances for many patients…
Mar 27, 2026