N/A N=11 Gastric pH and Anthocyanin Absorption
Anthocyanin Metabolism
Primary: Gastric pH — 0.96; 2.31 pH
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=35 Anthocyanin Extract and Phospholipid Curcumin in Colorectal Adenoma
Colorectal Adenoma · Risk Reduction
Primary: Change in Beta Catenin Expression — 100; 100; 100; 100 percentage of positive cells
Phase 2 N=12 Novel 13C Carotenoids for Absorption and Metabolism Studies in Humans
Healthy
Primary: Plasma Half Life of Labeled Carotenoid — 6.2; 2.3 days
N/A N=29 Evaluating the Availability of Berry Phytonutrients Post-consumption of Fresh and Processed Blueberry by Healthy Adults
Healthy
Primary: Total Urinary Recovery of (Poly)Phenolic Metabolites Across Treatments — 179.50; 142.41; 127.78; 83.15 mg — p=<0.05
N/A N=48 Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans
Human Health · Reactive Carbonyl Species · Polyphenols
Primary: Change in Urinary Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 8 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry…
Phase 2 N=10 Inflammation, Polyphenols, and Genetics
Overweight · Obese
Primary: Serum IL-6 — 42.4; 34.3 (pg*hr)/mL
N/A N=55 Blueberry Consumption and Type 2 Diabetes
Type2 Diabetes
Primary: Blood Pressure — 125.6; 126.0; 74.6; 75.1 mm Hg — p=0.56
N/A N=10 Matrix on Fruit Constituent Bioavailability
Healthy Non-smoker
Primary: CMax in Polyphenol Anthocyanin Concentrations — 8.7; 22.1; 7.6; 11.3 nmol/L
N/A N=360 Alcohol Metabolism and Disease Risk in Asians
Healthy
Primary: Peak Number of Alcohol Drinks Consumed in a Day — 3.7; 4.2; 3.4; 3.0 drinks — p=.81
N/A N=30 Role of Flavanols In Cardiovascular Function in Healthy Aging
Aging
Primary: Cutaneous Blood Flow Response to Local Heating of the Skin. — 68; 70 percent change in mean skin blood flow
N/A N=8 A Single Supplement of a Standardised Bilberry Extract Modifies Glycaemic Response
Type 2 Diabetes
Primary: Plasma Glucose iAUC (Incremental Area Under the Curve; mM*Min) — 836; 693 glucose iAUC (mM*min) — p=0.003
N/A N=10 Physiological Effects of New Polyphenol-enriched Foods in Humans
Healthy
Primary: Serum Polyphenol Concentrations Over 24h From Food Consumption — 1.7; 12.1; 7.7; 0.01 nmol*h/L — p=0.02
N/A N=38 Impacts of Lentils on Metabolism and Inflammation
Hypertriglyceridemia · Inflammation · Waist, Hypertriglyceridemic
Primary: Change in Postprandial Serum Triglyceride — -0.1; 0.2 mmol*hr/L
N/A N=20 Berries, Bugs, and the Blues
Depressive Symptoms
Primary: Depressive Symptom Severity — -5; -4 scores on a scale
N/A N=29 Blueberries, Inflammation, Motivation, and Physical Activity
Depressive Symptoms
Primary: Change in Engagement in Physical Activity — 318; 346 steps per day
N/A N=6 ABSORB (Amount of Blueberries So Older Adults Reap Benefits)
Depressive Symptoms · Aging
Primary: Urinary Flavonoid Biomarkers — 398863; 1045795 Unitless
Phase 3 N=70 Efficacy of Anthocyanin Mouthrinse for Oral Anti-inflammation From Orthodontic Treatment
Inflammation of Mouth · Acute Mucous Inflammation
Primary: Wound Size (mm^2) Reduction — 11.26; 8.92 mm^2
N/A N=70 The Purple Grape Juice Study
Cardiovascular Disease
Primary: Compare Change in Platelet Aggregation as Measured by Adenosine Diphosphate (ADP) Between PGJ and Placebo — 1.59; -12.3 percent
N/A N=14 Response of Alkylresorcinols to Different Cereals
Healthy
Primary: Plasma Alkylresorcinol Compounds — 19357; 1548; 17307; 5385 nmol/L*h
N/A N=44 The Blueberry Study
Healthy
Primary: Phenolic Acid Metabolites Measured in Plasma and Urine After Dietary Intervention — 13; 0; 25; 3 Counts of metabolites
N/A N=12 Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress
Inflammation
Primary: Reduced Glutathione (GSH) Concentrations in Red Blood Cells — 1.38; 1.22; 1.23; 1.12 mmol/L
N/A N=18 Impacts of a Combined Berry Extract Supplement on Vascular Function and Oxygen Utility Capacity in Young Adults
Healthy
Primary: Endothelial Function — 11.7; 8.2 percent dilation
Phase 1 N=24 Purple Grape Juice in Improving Vascular Health in Childhood Cancer Survivors
Cardiovascular Disease
Primary: Change in Endothelial Function (Reactive Hyperemia Peripheral Arterial Tonometry (RH-PAT) Index Score) — 0.06; 0.22 units on a scale — p=0.25
Phase 2 N=30 The Efficient Brain Study
Metabolism - Cerebral Energy
Primary: Magnetic Resonance Spectroscopy (MRS) Will Measure a Change in Cerebral Energy Function in Brain Tissue — .011; .007; .009; .006 Difference in metabolite amplitude
Phase 2 N=32 Healthy Aging Through Functional Food
Glucose Intolerance · Aortic Stiffness · Vasodilation
Primary: Area Under the Curve for Oral Glucose Tolerance Test (oGGT) — 10.8; 11.0; 9.9; 10.6 mM h
Phase 1 N=60 Aborption and Metabolism of Lyophilized Black Raspberry Food Products in Men With Prostate Cancer Undergoing Surgery
Stage I Prostate Cancer · Stage IIA Prostate Cancer · Stage IIB Prostate Cancer
Primary: Adverse Events Assessed Using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0 — 0; 0; 0; 0 Participants
Phase 1 N=12 Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin
Pre-diabetes
Primary: Change From Baseline in Circulating Urinary Concentrations of Intact Epicatechin and Epi Metabolites — 105.8; 132.7; 162.3; 291.3 nM*hr — p=0.05
N/A N=23 Red and Processed Meat Effects on the Metabolome and Microbiome
Controlled Feeding Trial · Healthy Eating Index · Red Meat
Primary: Test the Effects of Red and Processed Meat on Aqueous Biomarkers of the Blood Metabolome — 0.87; 0.60; 3.48; 5.66 ratio of day 21 to day 0
N/A N=38 Mechanisms of Obesity and Its Metabolic Complications in Youth
Obesity, Childhood
Primary: Rate of Appearance of Acetate — 7.40; 7.69; 9.29; 14.7 umol/kg/min
N/A N=18 Comparing the Effect of Whey and Soy Protein on the Absorption of Pomegranate Polyphenols in the Human Body
Healthy
Primary: Plasma Ellagic Acid Concentration 0 to 24 Hours Post-dose Area Under the Curve — 0.074; 0.075 micromol*h/L — p=0.82