N/A N=78 Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
Alzheimer Disease · Dementia
Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=63 Effect of Mental Imagery Training on Brain Plasticity and Motor Function in Individuals With Parkinson's Disease
Parkinson Disease
Primary: Change in Right Insula-dorsomedial Frontal Cortex Functional Connectivity Strength. — 93.2; 97.8 percent change from baseline — p=0.981
Phase 2 N=73 Cognitive Stimulation
Substance Use Disorders
Primary: Working Memory — 0.86; 0.04 digits recalled
N/A N=49 Cognitive Dysfunction in Parkinson's Disease
Parkinson's Disease
Primary: Change in Magnetoencephalography (MEG) Connectivity Measures
Phase 2 N=30 The Efficient Brain Study
Metabolism - Cerebral Energy
Primary: Magnetic Resonance Spectroscopy (MRS) Will Measure a Change in Cerebral Energy Function in Brain Tissue — .011; .007; .009; .006 Difference in metabolite amplitude
N/A N=283 Polyunsaturated Fatty Acids (PUFA) Status and Cognitive Function in Healthy Young Adults
Attention · Memory · Mood
Primary: Simple Reaction Time (Attention) — 287.7 ms
N/A N=39 Theta Connectivity in Working Memory
Executive Function
Primary: Number of Remembered Items — 1.72; 1.68; 1.68; 1.65 remembered items — p=0.783
N/A N=36 Brain Function and Decision-Making
Behavior, Social · Psychology, Social · Social Interaction
Primary: Change in Prefrontal Cortex Brain Activity Assessed by fMRI — -0.002; 0.015 Percent BOLD Signal Change
N/A N=12 Brain Stimulation and Cognitive Training
Bipolar Disorder · Schizo Affective Disorder · Schizophrenia
Primary: Participant Retention in Combination Treatment — 4; 5 Participants
Phase 2 N=40 Metformin Effect on Brain Function in Insulin Resistant Elderly People
Insulin Resistance · Obesity · Obesity, Abdominal
Primary: Change From Baseline in Brain PCr/ATP Ratio as Measured by Phosphorus Magnetic Spectroscopy (31P-MRS) After 10 Months of Metformin Administration — -0.045; -0.016…
N/A N=15 Brain Stimulation and Cognitive Training - Efficacy
Schizophrenia · Schizo Affective Disorder · Bipolar Disorder
Primary: Change in Working Memory Performance - Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB)…
N/A N=178 The Effects of Executive Functions and Social Cognition on Mental Health
Autism or Autistic Traits · Mental Health Disorder · Executive Dysfunction
Primary: Depression_1 — 9.87; 10.24; 7.65; 9.15 score on a scale
Phase 3 N=11 Effects of Growth Hormone on Cognition and Cerebral Metabolism in Adults With Growth Hormone Deficiency
Hypopituitarism
Primary: BOLD Signal Measured by Functional MRI Scan to Functional Connectivity Measured by fMRI
N/A N=180 MINDSpeed Food and Brain Training RCT
Low Education · Cognition · Cognitive Training
Primary: Executive Cognitive Function Composite Score — 0.211; 0.100; 0.142; 0.196 units on a scale
N/A N=20 Aerobic Exercise to Improve Executive Language Function In Older Adults
Aging
Primary: Executive Language Functions — 31.6; 30.8; 33.7; 31.8 Mean outpoint by group at pre and post
N/A N=18 Brain Markers of Improvements in Cognitive Functioning
TBI (Traumatic Brain Injury) · Brain Injuries · Stress
Primary: Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery — 0.18; -0.06 units on a scale
N/A N=53 Mindfulness Training, Mental Fatigue, Endurance Performance and Neurocognitive Functions
Mindfulness Training · Neurocognitive Function · Sports Performance
Primary: Inhibitory Control: Reaction Time — 10.79; 5.47; 4.11; -0.61 millisecond — p=> 0.05
N/A N=42 Cerebral Haemodynamic Changes During Cognitive Testing: A fTCD Study
Mild Cognitive Impairment · Alzheimer Disease · Vascular Dementia
Primary: Percentage of Recruited Subjects Able to Comply With the Protocol — 12; 13; 3; 14 Participants
N/A N=19 The Effects of Noninvasive Brain Stimulation on Physical and Mental Functioning in Older Adults
Aging
Primary: Percent Change From Baseline to Post Intervention on Mobility — -3.0; 10.4; -6.1; 3.4 percent change of TUG time — p=0.24
Phase 4 N=143 Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression
Depression
Primary: Hamilton Depression Rating Scale (HDRS) Maintained Scores at Week 16 — 18.3; 18.7; 19.8 units on a scale
N/A N=91 Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS
Traumatic Brain Injury · Post-Traumatic Stress Disorder
Primary: Change From Baseline in Community Reintegration for Injured Service Members at 2 Months — 40.22; 37.79 score on a scale
N/A N=53 Theta Burst Transcranial Magnetic Stimulation of Fronto-parietal Networks: Modulation by Mental State
Healthy
Primary: 2-back Minus 1-back Blood Oxygen Level-Dependent (BOLD) Activation, Voxelwise in FPN — 0.74; 0.75; 0.58 arbitrary units — p==0.11
N/A N=40 Probing Cortical Excitability and Cognitive Function With TMS
Cognitive Dysfunction
Primary: Cortical Excitability: Resting Motor Threshold (RMT). — 51.1; 51.8 % of Max Stimulation Output (MSO)
N/A N=40 Preventing Cognitive Decline
Cognitive Decline
Primary: Percentage of Trials Correct On Working Memory Test — 87.69; 91.57; 88.01; 91.68 percentage of correct trials — p=>0.05
N/A N=211 Dietary Flavanols and Dentate Gyrus Function
Memory Loss
Primary: Modified Benton Recognition Task (ModBent) — 2807.98; 2579.94; 2603.65; 2732.79 ms — p=.393
N/A N=22 Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Change From Baseline in California Verbal Learning Task Score — 3.04; 5.17; 4.22; 7.04 score on a scale
N/A N=108 Behavioral Differences in Effortful Control
Healthy
Primary: Reaction Time on the Multi-Source Interference Task — 300; 330; 310; 280 milliseconds — p=0.159
Phase 3 N=17 Curcumin and Function in Older Adults
Older Adults · Physical Function · Cognitive Function
Primary: Curcumin and Physical Function -Walking — 0.014; 0.103 meters/second
N/A N=184 Using TMS to Increase Executive Function in Older Adults
Aging
Primary: Acute Effect of a rTMS Session on the Performance for a Working Memory Task, as Measured by Accuracy (in Percentage) — 50.43; 55.42; 83.93; 46.49 percentage of accuracy
Phase 4 N=2,176 Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo
Hypercholesterolemia
Primary: Change From Baseline in Cambridge Neuropsychological Test Automated Battery (CANTAB) Cognitive Domain Spatial Working Memory (SWM) Strategy Z-Score at Week 96 — -0.180…