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Home › Conditions › acute liver failure

Acute liver failure

Subtypes of Acute liver failure

Acute-on-chronic liver failure 3

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for acute liver failure

3 trials tracked for acute liver failure: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 120 citations.

3Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 2 Phase 2 1
  1. Phase 3 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF Completed · 120 cited
  2. Phase 3 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed
  3. Phase 2 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury Completed

Showing the 3 most-cited and recently-updated of 3 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

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Patient Mode — summaries use plain language, avoiding clinical jargon.
Narrative review on sepsis in end-stage liver disease and acute-on-chronic liver failure
Drug Pipeline Sys. Review
Narrative review on sepsis in end-stage liver disease and acute-on-chronic liver failure Patients with severe liver disease and sepsis face high risks and need careful care plans
This narrative review synthesizes evidence on sepsis in patients with end-stage liver disease and acute-on-chronic liver failure. It describ…
People with advanced liver sickness and sepsis often have weak immune systems and get hard-to-treat infections. Doctors say new treatments l…
Frontiers May 7, 2026
Five ACLF diagnostic models and prognostic scores identified markedly different proportions of patients at risk of 28-day mortality in a cohort study
Gastroenterology Cohort
Five ACLF diagnostic models and prognostic scores identified markedly different proportions of patients at risk of 28-day mortality in a cohort study Two new models find the sickest liver patients faster than old tools
This cohort study evaluated five acute-on-chronic liver failure (ACLF) diagnostic models and prognostic scores in 3,370 patients from the CO…
Two new scoring systems find the most dangerous liver failure patients better than older tools, potentially saving lives by catching risk ea…
medRxiv May 1, 2026
Cochrane review finds very low-certainty evidence on liver support systems for acute liver failure mortality
Psychiatry Sys. Review
Cochrane review finds very low-certainty evidence on liver support systems for acute liver failure mortality Liver support systems may not reduce death risk in acute liver failure
This Cochrane systematic review evaluates liver support systems versus standard medical care in adults with acute liver failure.
A major review of 681 patients found liver support systems likely offer little to no benefit over standard care for reducing death or seriou…
Cochrane Apr 28, 2026
Thymosin alpha1 added to standard therapy improved 90-day transplant-free survival in 73 patients with HBV-related acute-on-chronic liver failure
Gastroenterology RCT
Thymosin alpha1 added to standard therapy improved 90-day transplant-free survival in 73 patients with HBV-related acute-on-chronic liver failure Thymosin alpha1 may improve survival in hepatitis B liver failure patients
This open-label randomized controlled trial enrolled 73 patients with hepatitis B virus-related acute-on-chronic liver failure.
Adding thymosin alpha1 to standard therapy helped hepatitis B liver failure patients survive longer without needing a transplant.
Apr 9, 2026
CAM products associated with ACLF in 39.6% of patients with liver injury in retrospective cohort
Gastroenterology Cohort
CAM products associated with ACLF in 39.6% of patients with liver injury in retrospective cohort CAM products linked to liver failure and heavy metal contamination in patients
A retrospective cohort study of 91 consecutive patients with CAM-related adverse events at a South Indian tertiary center found that 39.6% d…
Many complementary medicine products tested contained dangerous heavy metals like cadmium linked to severe liver failure and death in patien…
Frontiers Apr 9, 2026