Narrative review on sepsis in end-stage liver disease and acute-on-chronic liver failure
Patients with severe liver disease and sepsis face high risks and need careful care plans
This narrative review synthesizes evidence on sepsis in patients with end-stage liver disease and acute-on-chronic liver failure. It describ…
People with advanced liver sickness and sepsis often have weak immune systems and get hard-to-treat infections. Doctors say new treatments l…
Five ACLF diagnostic models and prognostic scores identified markedly different proportions of patients at risk of 28-day mortality in a cohort study
Two new models find the sickest liver patients faster than old tools
This cohort study evaluated five acute-on-chronic liver failure (ACLF) diagnostic models and prognostic scores in 3,370 patients from the CO…
Two new scoring systems find the most dangerous liver failure patients better than older tools, potentially saving lives by catching risk ea…
Thymosin alpha1 added to standard therapy improved 90-day transplant-free survival in 73 patients with HBV-related acute-on-chronic liver failure
Thymosin alpha1 may improve survival in hepatitis B liver failure patients
This open-label randomized controlled trial enrolled 73 patients with hepatitis B virus-related acute-on-chronic liver failure.
Adding thymosin alpha1 to standard therapy helped hepatitis B liver failure patients survive longer without needing a transplant.
Research across Acute liver failure
Related studies from across the Acute liver failure family.
Cochrane review finds very low-certainty evidence on liver support systems for acute liver failure mortality
Liver support systems may not reduce death risk in acute liver failure
This Cochrane systematic review evaluates liver support systems versus standard medical care in adults with acute liver failure.
A major review of 681 patients found liver support systems likely offer little to no benefit over standard care for reducing death or seriou…
CAM products associated with ACLF in 39.6% of patients with liver injury in retrospective cohort
CAM products linked to liver failure and heavy metal contamination in patients
A retrospective cohort study of 91 consecutive patients with CAM-related adverse events at a South Indian tertiary center found that 39.6% d…
Many complementary medicine products tested contained dangerous heavy metals like cadmium linked to severe liver failure and death in patien…