Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Atrial septal defect

Atrial septal defect

Part of Heart Defects, Congenital

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Atrial septal defect

11 trials tracked for Atrial septal defect: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 6 citations.

11Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 3 1 Phase 2 1 Phase 1 1 Other / NA 7
  1. Phase 4 Regional Anesthesia Following Pediatric Cardiac Surgery Completed · 6 cited
  2. Phase 3 The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart Disease Completed
  3. Phase 2 Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol Completed
  4. Phase 1 Utilization of Confocal Microscopy During Cardiac Surgery Completed
  5. N/A Philips Intracardiac Echocardiography (ICE) Clinical Registry Completed
  6. N/A Safety and Efficacy Study of Transcatheter Closure of Ostium Secundum ASDs Completed
Show 5 more trials
  1. N/A Safety and Efficacy of the GORE® Septal Occluder to Treat Ostium Secundum Atrial Septal Defects Completed
  2. N/A Closure of Atrial Septal Defects With the AMPLATZER Septal Occluder - Post Approval Study Completed
  3. N/A Long-term Safety Study of the GORE® HELEX® Septal Occluder Completed
  4. N/A Safety and Efficacy Study of Absnow Absorbable ASD Closure System For Treating ASD Patients Completed
  5. N/A Feasibility Study on the VERAFEYE System Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Atrial septal defect: what the trials found

In the management of atrial septal defect, the administration of Ropivacaine 0.2% Injectable Solution was associated with a significant reduction in the total amount of opioid medications administered (p=0.004) 3.

The use of Dexmedetomidine in combination with Sevoflurane resulted in measurable changes in hemodynamic variables during administration (p=0.05) 4.

Recent results — preliminary, needs further review

  • Absnow Absorbable ASD Closure System is currently under investigation 1.
  • VERAFEYE System is currently under investigation 2.

For the clinician treating this condition

  • Ropivacaine 0.2% Injectable Solution can be utilized to reduce the total volume of opioids required during procedures 3.
  • Dexmedetomidine combined with Sevoflurane impacts hemodynamic variables during administration 4.

AI synthesis of 4 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Percutaneous closure using the poly-L-lactic acid (PLLA) device in pediatric patients with atrial septal defect
Cardiology Cohort
Percutaneous closure using the poly-L-lactic acid (PLLA) device in pediatric patients with atrial septal defect New Device Closes Heart Holes in Kids
This prospective, single-center, first-in-human trial evaluated percutaneous closure using the poly-L-lactic acid (PLLA) device in 36 pediat…
A new milk-protein heart device closed holes in kids for five years, letting their bodies heal naturally without permanent metal implants.
Frontiers Apr 20, 2026

Research across Heart Defects, Congenital

Related studies from across the Heart Defects, Congenital family.

Synchronous PCG-ECG monitoring may supplement echocardiography for pediatric VSD subtype diagnosis
Pediatrics Cohort
Synchronous PCG-ECG monitoring may supplement echocardiography for pediatric VSD subtype diagnosis A Stethoscope Upgrade May Spot Holes in Kids' Hearts Faster
A prospective cohort study of 59 children with suspected ventricular septal defect (VSD) found that synchronous phonocardiogram-electrocardi…
A wearable device that records a child's heartbeat and heart sounds together may flag subtle differences between two kinds of heart holes.
Frontiers Apr 13, 2026