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Avian Influenza

Part of Orthomyxoviridae Infections

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Avian Influenza

11 trials tracked for Avian Influenza: 2 in phase 3 or 4 and 2 with published results. The most-cited published study has 8 citations.

11Trials tracked
2Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 2 Phase 2 8 Phase 1 1
  1. Phase 3 A Safety and Immunogenicity Study of IVACFLU-A/H5N1 Completed · 8 cited
  2. Phase 3 A Study to Evaluate Safety, Immunogenicity, and Lot-to-Lot Consistency of H5N1 Subunit Influenza Virus Vaccine in Healthy Adult Subjects ≥18 Years of Age Completed · 3 cited
  3. Phase 2 Immunogenicity, Safety and Tolerability of Prepandemic Influenza and Seasonal Influenza Vaccine in Adult Subjects Completed
  4. Phase 2 Co-Administration of AS03 Adjuvanted A/H7N9 IIV With IIV4 Completed
  5. Phase 2 2017 A/H7N9 IIV Revaccination Completed
  6. Phase 2 2013/2017 H7N9 Prime-Boost Interval Completed
Show 5 more trials
  1. Phase 2 Sanofi 2017 H7N9 With/Without AS03 in Adults/Elderly Completed
  2. Phase 2 High-Dose Versus Standard-Dose Oseltamivir to Treat Severe Influenza and Avian Influenza Completed
  3. Phase 2 H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses Completed
  4. Phase 2 Safety/Efficacy Study of Seqirus A/H7N9 IIV With or Without MF59(R) Adjuvant to Prevent Avian Influenza Completed
  5. Phase 1 Safety Trial of Live Attenuated Influenza (H7N3) Vaccine Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Avian Influenza: what the trials found

Multiple trials evaluated the immunogenicity of various influenza vaccine candidates, including those targeting H5N1 and H7N9. For H5N1-specific vaccines, studies demonstrated varying levels of success in achieving Hemagglutination Inhibition (HAI) titers of 1:40 or greater; for example, one study showed a range of 13.0% to 95.0% across different age cohorts 2, while another reported seroconversion rates between 38% and 51% following the second vaccination 8.

Vaccines targeting H7N9 consistently demonstrated significant immunogenicity. Trials using the AS03 adjuvant showed HAI seroconversion rates ranging from 38% to 65% [7, 8] and neutralizing antibody seroconversions of up to 82% 8. Other H7N9 vaccine studies reported high rates of neutralizing antibody titers (up to 100%) and varying levels of HAI seroconversion across different study arms [4, 5, 6].

Specific trial data for the IVACFLU-A/H5N1 vaccine showed that a significant portion of participants achieved at least a 4-fold increase in HAI titers after vaccination, with rates reaching up to 93% 1.

Recent results — preliminary, needs further review

  • Oseltamivir was evaluated for viral RNA clearance and clinical failure; however, results did not reach statistical significance (p=0.54 and p=0.42 respectively) 9.
  • MF59-eH5N1 vaccine showed geometric mean ratios for various influenza strains, but these findings are currently not corroborated 10.
  • LAIV H7N3 was evaluated for seroconversion of HAI, neutralizing antibodies, and IgA, but results are not yet corroborated 11.

For the clinician treating this condition

  • Vaccines targeting H7N9 consistently induce significant neutralizing antibody titers (up to 100%) and high rates of HAI seroconversion across multiple trial designs [4, 5, 6].
  • The addition of the AS03 adjuvant in H7N9 vaccines is associated with robust immune responses, including neutralizing antibody seroconversions reaching up to 82% 8.
  • Immunogenicity for H5N1 varies significantly by cohort; however, specific formulations like IVACFLU-A/H5N1 have shown high rates of HAI titer increases in some participants [1, 2].

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.

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