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Brain tumor

Part of Brain Metastasis

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for brain tumor

36 trials tracked for brain tumor: 9 in phase 3 or 4 and 1 with published results. The most-cited published study has 254 citations.

36Trials tracked
9Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 4 Phase 3 5 Phase 2 19 Phase 1 4 Other / NA 4
  1. Phase 3 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed · 254 cited
  2. Phase 4 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients Completed
  3. Phase 4 Multihance at 3 Tesla (3T) in Brain Tumors Completed
  4. Phase 4 A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients Completed
  5. Phase 4 Learning Impairments Among Survivors of Childhood Cancer Completed
  6. Phase 3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed
Show 30 more trials
  1. Phase 3 An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies Completed
  2. Phase 3 XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors Completed
  3. Phase 3 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed
  4. Phase 2 A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects Completed
  5. Phase 2 Suberoylanilide Hydroxamic Acid (SAHA), Bevacizumab, Daily Temozolomide for Recurrent Malignant Gliomas Completed
  6. Phase 2 Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas Completed
  7. Phase 2 Study of Tesevatinib Monotherapy in Patients With Recurrent Glioblastoma Completed
  8. Phase 2 Carboplatin and Temozolomide (Temodar) for Recurrent and Symptomatic Residual Brain Metastases Completed
  9. Phase 2 Zoledronate in Preventing Osteoporosis in Patients With Primary Malignant Glioma Completed
  10. Phase 2 Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM Completed
  11. Phase 2 A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas Completed
  12. Phase 2 PPX, Temozolomide, and Concurrent Radiation for Newly Diagnosed Brain Tumors Completed
  13. Phase 2 Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors Completed
  14. Phase 2 Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors Completed
  15. Phase 2 Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma Completed
  16. Phase 2 LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma Completed
  17. Phase 2 Radiation Therapy in Treating Young Patients With Gliomas Completed
  18. Phase 2 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed
  19. Phase 2 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed
  20. Phase 2 Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation Completed
  21. Phase 2 Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma Completed
  22. Phase 2 Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas Completed
  23. Phase 1 [F-18] Fluorothymidine (FLT) Imaging on Patients With Primary Brain Tumors Completed
  24. Phase 1 Nicardipine vs Esmolol Craniotomy Emergence Completed
  25. Phase 1 IDH1 Peptide Vaccine for Recurrent Grade II Glioma Completed
  26. Phase 1 Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma Completed
  27. N/A Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer Completed
  28. N/A Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma Completed
  29. N/A Pilot Study Effect of Sulfasalazine on Glutamate Levels by(Magnetic Resonance Spectroscopy)MRS in Patients With Glioma Completed
  30. N/A Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma Completed

Showing the 36 most-cited and recently-updated of 36 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Brain Metastasis

Related studies from across the Brain Metastasis family.

NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions
Radiology & Imaging Meta-analysis
NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions Brain scan technique helps tell gliomas from metastases
This meta-analysis evaluates the use of Neurite orientation dispersion and density imaging (NODDI) to distinguish gliomas from brain metasta…
A new imaging method may help doctors distinguish between gliomas and brain metastases without invasive biopsy.
ctDNA positivity linked to increased risk of brain metastases in advanced solid tumors
Oncology Meta-analysis
ctDNA positivity linked to increased risk of brain metastases in advanced solid tumors ctDNA in blood and spinal fluid predicts brain metastases risk
This systematic review and meta-analysis of 1763 patients with advanced solid tumors found that ctDNA positivity is associated with a signif…
A new analysis finds that tumor DNA in blood or spinal fluid can signal a higher risk of brain metastases and worse survival.
Local brain therapies associated with reduced mortality in HNSCC patients with brain metastasis
Oncology Cohort
Local brain therapies associated with reduced mortality in HNSCC patients with brain metastasis Local brain treatments linked to modest survival gains in rare head and neck cancer cases
This retrospective cohort analysis evaluated 201 patients with head and neck squamous cell carcinoma and brain metastasis from three tertiar…
Local brain treatments linked to lower death risk for rare head and neck cancer patients who develop brain metastases, though most still die…
WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
Oncology Meta-analysis
WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis Whole-brain radiation shows no clear survival benefit for thyroid cancer brain metastases
A systematic review and individual patient data meta-analysis of 247 patients with thyroid cancer brain metastases found whole-brain radiati…
Whole-brain radiation therapy showed no clear survival benefit for patients with thyroid cancer that spread to their brain.
Adding WBRT to SRS cuts brain metastasis recurrence but raises cognitive decline without survival gain
Oncology Meta-analysis
Adding WBRT to SRS cuts brain metastasis recurrence but raises cognitive decline without survival gain Adding whole-brain radiation to SRS lowers recurrence but does not extend life for brain metastases patients
This meta-analysis of 1,757 patients with brain metastases found that adding whole-brain radiotherapy (WBRT) to stereotactic radiosurgery (S…
Combining SRS with whole-brain radiation lowers tumor recurrence but does not improve survival compared to SRS alone for patients with brain…
Systematic review examines tumor microenvironment mechanisms in lung cancer brain metastases
Infectious Disease Sys. Review
Systematic review examines tumor microenvironment mechanisms in lung cancer brain metastases New brain strategies target lung cancer before it spreads
This systematic review explores the complex mechanisms driving brain metastasis in patients with lung cancer.
Doctors are finding clever new ways to fight lung cancer that has spread to the brain without breaking the body's natural barriers
Narrative Review Examines Stereotactic Radiotherapy Use in Cancer Patients With Brain Metastases
Oncology Sys. Review
Narrative Review Examines Stereotactic Radiotherapy Use in Cancer Patients With Brain Metastases More Brain Mets? This Radiation Advance Changes Everything
This narrative review examines the role of stereotactic radiotherapy in cancer patients with brain metastases.
Every year, more cancer patients face a terrifying diagnosis: brain metastases.
Retrospective observational study evaluates systemic therapy surveillance in brain metastases patients
Oncology Guideline
Retrospective observational study evaluates systemic therapy surveillance in brain metastases patients Observational study examines MRI surveillance patterns in patients with active brain metastases
This retrospective observational study abstract examines surveillance practices in 33 patients with active brain metastases treated with sys…
Doctors monitoring brain metastasis patients with new drugs found no difference in tumor growth or radiation needs whether they followed gui…
Stereotactic radiation improves symptoms versus hippocampal-avoidance whole brain radiation in patients with 5 to 20 brain metastases
Drug Pipeline RCT
Stereotactic radiation improves symptoms versus hippocampal-avoidance whole brain radiation in patients with 5 to 20 brain metastases Targeted Brain Radiation Eases Symptoms More Than Full-Brain Treatment
This Phase 3 randomized clinical trial enrolled 196 patients with 5 to 20 brain metastases and no prior brain-directed radiation across four…
Targeted radiation for brain tumors preserves daily functioning and quality of life better than whole-brain treatment in cancer patients wit…
First-line osimertinib shows high response rates in EGFR-mutated NSCLC with active brain metastases
Pulmonology & Critical Care Phase II
First-line osimertinib shows high response rates in EGFR-mutated NSCLC with active brain metastases Untreated Brain Metastases Respond Well to Osimertinib
This single-arm phase II trial evaluated first-line osimertinib in 100 patients with EGFR-mutated non-small cell lung cancer, including thos…
Osimertinib, a lung cancer drug, effectively treats untreated brain metastases, with an 81.8% response rate for measurable brain spots in a …
Elevated neutrophil-to-lymphocyte ratio predicts brain metastasis risk in lung cancer patients
Oncology Meta-analysis
Elevated neutrophil-to-lymphocyte ratio predicts brain metastasis risk in lung cancer patients Could a simple blood test help find who is most at risk for brain metastasis from lung cancer?
This systematic review and meta-analysis evaluated three immune inflammatory markers in 3,643 participants with lung cancer.
A simple blood test showing high inflammation markers can predict who is most likely to develop brain metastasis from lung cancer.
Hypofractionated stereotactic radiation therapy showed high local control in breast cancer brain metastases
OB/GYN & Women's Health Phase II
Hypofractionated stereotactic radiation therapy showed high local control in breast cancer brain metastases FSRT shows promising results for brain metastases in breast cancer patients
This prospective single-arm phase 2 trial evaluated fractionated stereotactic radiation therapy (FSRT) in 173 patients with breast cancer an…
Fractionated stereotactic radiation therapy kept brain cancer controlled in 88.6% of breast cancer patients after one year with no severe si…

Questions about brain tumor

How does the new framework improve brain tumor MRI analysis accuracy?

New frameworks improve brain tumor MRI analysis by using geometric math to handle missing scans, combining deep learning with data balancing, and standardizing how doctors measure tumor response.

Full answer →