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Home › Conditions › Carpal Tunnel Syndrome

Carpal Tunnel Syndrome

Part of Peripheral neuropathy

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Carpal Tunnel Syndrome

17 trials tracked for Carpal Tunnel Syndrome: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 140 citations.

17Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 2 Other / NA 12
  1. Phase 4 Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome Completed · 140 cited
  2. Phase 4 Preoperative Antibiotics for Carpal Tunnel Release Surgery Completed
  3. Phase 3 Preoperative Gabapentine for Carpal Tunnel Completed
  4. Phase 2 A Study of Fisetin to Treat Carpal Tunnel Syndrome Completed
  5. Phase 2 BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome Completed
  6. N/A Local Effects of Acupuncture and Nerve Conduction Studies Completed
Show 11 more trials
  1. N/A Study Protocol for CTS and Keyboard Controlled Randomized Trial Completed
  2. N/A Testing of a Tool to Elicit Patient Preferences for CTS Completed
  3. N/A Comparison of Two Techniques for the Treatment of Carpal Tunnel Syndrome Completed
  4. N/A Static Magnetic Therapy for Carpal Tunnel Syndrome Completed
  5. N/A Comparative Effectiveness of Ultrasound and Paraffin Therapy in Patients With Carpal Tunnel Syndrome: A Randomized Trial Completed
  6. N/A Safety and Efficacy of a Novel Carpal Tunnel Tissue Manipulation Device in Treating Carpal Tunnel Syndrome Completed
  7. N/A Continuous And Pulsed Ultrasound Treatments On Carpal Tunnel Syndrome Completed
  8. N/A Trial of Ultrasound Guided Carpal Tunnel Release Versus Traditional Open Release (TUTOR) Completed
  9. N/A Multicenter Prospective Trial of Office-based Carpal Tunnel Release With Ultrasound Guidance (ROBUST) Completed
  10. N/A Non-invasive CTS Device Clinical Trial Completed
  11. N/A Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release? Completed

Showing the 17 most-cited and recently-updated of 17 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Carpal Tunnel Syndrome: what the trials found

Gabapentine was shown to significantly reduce chronic pain in patients with Carpal Tunnel Syndrome (p<0.05) 3.

While ultrasound has been utilized as an intervention or diagnostic tool in established protocols, clinical trials did not report statistically significant improvements in symptom severity (p=0.442), pain scores (p=0.083), or functional status (p=0.125) [11, 13].

Administration of Methylprednisolone 80 mg was evaluated for its impact on symptom severity, palmar pain, and DASH scores 1.

Recent results — preliminary, needs further review

  • Fisetin showed a change in the Boston Carpal Tunnel Syndrome (BCTQ) Score of -0.5 4.

For the clinician treating this condition

  • Gabapentine is an established intervention for reducing chronic pain associated with the condition 3.
  • Ultrasound-based interventions did not demonstrate statistically significant improvements in symptom severity or functional status in the studied cohorts 11.

AI synthesis of 4 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Gout Should Be Considered in Atypical, Acute, Severe, Recurrent, Bilateral, or Mass-Associated Carpal Tunnel Syndrome
Orthopedics & Sports Medicine Meta-analysis
Gout Should Be Considered in Atypical, Acute, Severe, Recurrent, Bilateral, or Mass-Associated Carpal Tunnel Syndrome Gout can cause carpal tunnel syndrome in some patients
This systematic review of 57 reports (at least 120 patients, 152 CTS wrists, 146 gout-attributable wrists) examines carpal tunnel syndrome a…
Gout is not just a joint issue; it can cause carpal tunnel syndrome, and doctors are identifying it in more cases.
Frontiers Oct 4, 2026
Kinesio Taping Plus Stretching Improves Pain and Function in Carpal Tunnel Syndrome
Anesthesiology & Pain Medicine RCT
Kinesio Taping Plus Stretching Improves Pain and Function in Carpal Tunnel Syndrome Home taping beats electrical stimulation for wrist pain and grip strength in adults
This randomized controlled trial in 42 adults with carpal tunnel syndrome compared home-based Kinesio taping plus myofascial stretching to T…
A home-based taping method combined with stretching improved wrist pain and grip strength more than electrical stimulation in adults with ca…
Apr 30, 2026