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Home › Conditions › Precocious Puberty

Precocious Puberty

Subtypes of Precocious Puberty

Central precocious puberty 4

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Precocious Puberty

6 trials tracked for Precocious Puberty: 4 in phase 3 or 4.

6Trials tracked
4Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 3 4 Phase 2 2
  1. Phase 3 Effects of Triptorelin Pamoate in Children With Precocious Puberty - Follow up Study Completed
  2. Phase 3 Study of Lupron Depot In The Treatment of Central Precocious Puberty Completed
  3. Phase 3 Efficacy and Safety Study of Pamoate of Triptorelin in Children With Precocious Puberty Completed
  4. Phase 3 A Study of Leuprolide 11.25 mg and 30 mg Administered Every 3 Months to Treat Central Precocious Puberty Completed
  5. Phase 2 Pediatrics Testotoxicosis Study [Bicalutamide Anastrozole Treatment for Testotoxicosis] Completed
  6. Phase 2 Faslodex in McCune-Albright Syndrome Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Multifactorial risk factors and preventive strategies for children with precocious puberty
Pediatrics Sys. Review
Multifactorial risk factors and preventive strategies for children with precocious puberty Identifying Key Risk Factors for Children with Precocious Puberty
This narrative review synthesizes risk factors for precocious puberty across eight domains including genetic, environmental, and lifestyle f…
New research identifies eight different areas, from genetics to lifestyle, that may influence the risk of early puberty in children.
Frontiers Sep 14, 2026
Botanical drug preparations and East Asian medicine show favorable signals for central precocious puberty
Drug Pipeline Sys. Review
Botanical drug preparations and East Asian medicine show favorable signals for central precocious puberty Botanical medicines show promise for children with early puberty
This systematic umbrella review evaluates botanical drug preparations and East Asian medicine interventions for children with CPP and ICPP. …
New research suggests that certain East Asian botanical medicines may help manage early puberty in children when combined with standard trea…
Frontiers Sep 13, 2026
Risk factors for intracranial lesions in males with central precocious puberty include neurological symptoms
Diabetes & Endocrinology Guideline
Risk factors for intracranial lesions in males with central precocious puberty include neurological symptoms New Research Identifies Genetic Links in Central Precocious Puberty
This clinical guideline reviews the etiology and risk factors of central precocious puberty (CPP) in males. It highlights a significant decr…
Recent data shows a significant drop in brain lesion prevalence among boys with precocious puberty compared to historical records.
Frontiers Jul 19, 2026
GnRHa treatment for central precocious puberty is associated with 2.7 cm greater adult height gain
Diabetes & Endocrinology Meta-analysis
GnRHa treatment for central precocious puberty is associated with 2.7 cm greater adult height gain GnRHa treatment helps girls with early puberty gain height
This meta-analysis of 35 noncomparative and 21 comparative observational studies evaluates GnRHa treatment in children with Central Precocio…
Girls with central precocious puberty who receive GnRHa treatment may gain an average of 2.7 cm more in adult height compared to those witho…
Jul 16, 2026
Leuprolide acetate associated with final adult height exceeding mid-parental height in girls with central precocious puberty
Pediatrics Cohort
Leuprolide acetate associated with final adult height exceeding mid-parental height in girls with central precocious puberty More Than Half of Girls on Puberty Therapy Beat Their Genetic Height Potential
This retrospective cohort study included 73 girls with central precocious puberty or early puberty treated with depot leuprolide acetate.
More than half of girls treated for early puberty ended up taller than their genetic prediction, with younger age at treatment being the key…
Frontiers Apr 28, 2026
Quarterly triptorelin showed comparable hormonal suppression to monthly dosing in Chinese girls with central precocious puberty
Pediatrics Cohort
Quarterly triptorelin showed comparable hormonal suppression to monthly dosing in Chinese girls with central precocious puberty Less Frequent Injections Work Just as Well for Girls With Early Puberty
This retrospective cohort study evaluated 70 Chinese girls with central precocious puberty treated at Fuzhou First General Hospital.
Girls with early puberty treated with quarterly injections achieved the same growth protection as monthly shots in a new study.
Frontiers Apr 18, 2026
GnRHa treatment in familial hCG syndrome associated with concurrent beta-hCG elevation in blood and CSF
Diabetes & Endocrinology Sys. Review
GnRHa treatment in familial hCG syndrome associated with concurrent beta-hCG elevation in blood and CSF When a Pregnancy Hormone Shows Up in a Child — and It Is Not Cancer
This case report describes an 8-year-old girl with central precocious puberty treated with a gonadotropin-releasing hormone agonist (GnRHa).
An inherited condition can mimic a brain tumor in children by raising pregnancy hormones, leading to unnecessary surgery and chemotherapy be…
Frontiers Apr 14, 2026
Meta-analysis links postnatal BPA exposure to increased odds of early pubertal onset in children
Pediatrics Meta-analysis
Meta-analysis links postnatal BPA exposure to increased odds of early pubertal onset in children Study finds link between BPA exposure and earlier puberty in girls
A systematic review and meta-analysis of 5,549 predominantly female children found higher postnatal BPA exposure was observationally associa…
Higher exposure to the plastic chemical BPA is linked to earlier puberty in girls, though this review cannot prove it causes the change.
Frontiers Apr 2, 2026

Questions about Precocious Puberty

Are there brain lesions associated with central Precocious Puberty in boys?

While brain lesions were historically common in boys with central precocious puberty (CPP), recent data shows they occur in a much smaller percentage of cases, with most cases being idiopathic.

Full answer →
Does exposure to BPA increase the risk of Precocious Puberty in girls?

Research suggests that exposure to Bisphenol A (BPA) and its substitutes may increase the risk of precocious puberty in girls.

Full answer →