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Diabetes & Endocrinology
Guideline
Risk factors for intracranial lesions in males with central precocious puberty include neurological symptoms
New Research Identifies Genetic Links in Central Precocious Puberty
This clinical guideline reviews the etiology and risk factors of central precocious puberty (CPP) in males. It highlights a significant decr…
Recent data shows a significant drop in brain lesion prevalence among boys with precocious puberty compared to historical records.
Frontiers
Jul 19, 2026
Diabetes & Endocrinology
Meta-analysis
GnRHa treatment for central precocious puberty is associated with 2.7 cm greater adult height gain
GnRHa treatment helps girls with early puberty gain height
This meta-analysis of 35 noncomparative and 21 comparative observational studies evaluates GnRHa treatment in children with Central Precocio…
Girls with central precocious puberty who receive GnRHa treatment may gain an average of 2.7 cm more in adult height compared to those witho…
Jul 16, 2026
Pediatrics
Cohort
Leuprolide acetate associated with final adult height exceeding mid-parental height in girls with central precocious puberty
More Than Half of Girls on Puberty Therapy Beat Their Genetic Height Potential
This retrospective cohort study included 73 girls with central precocious puberty or early puberty treated with depot leuprolide acetate.
More than half of girls treated for early puberty ended up taller than their genetic prediction, with younger age at treatment being the key…
Frontiers
Apr 28, 2026
Pediatrics
Cohort
Quarterly triptorelin showed comparable hormonal suppression to monthly dosing in Chinese girls with central precocious puberty
Less Frequent Injections Work Just as Well for Girls With Early Puberty
This retrospective cohort study evaluated 70 Chinese girls with central precocious puberty treated at Fuzhou First General Hospital.
Girls with early puberty treated with quarterly injections achieved the same growth protection as monthly shots in a new study.
Frontiers
Apr 18, 2026
Diabetes & Endocrinology
Sys. Review
GnRHa treatment in familial hCG syndrome associated with concurrent beta-hCG elevation in blood and CSF
When a Pregnancy Hormone Shows Up in a Child — and It Is Not Cancer
This case report describes an 8-year-old girl with central precocious puberty treated with a gonadotropin-releasing hormone agonist (GnRHa).
An inherited condition can mimic a brain tumor in children by raising pregnancy hormones, leading to unnecessary surgery and chemotherapy be…
Frontiers
Apr 14, 2026
Pediatrics
Meta-analysis
Meta-analysis links postnatal BPA exposure to increased odds of early pubertal onset in children
Study finds link between BPA exposure and earlier puberty in girls
A systematic review and meta-analysis of 5,549 predominantly female children found higher postnatal BPA exposure was observationally associa…
Higher exposure to the plastic chemical BPA is linked to earlier puberty in girls, though this review cannot prove it causes the change.
Frontiers
Apr 2, 2026