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Chronic Wounds

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Chronic Wounds

31 trials tracked for Chronic Wounds: 11 in phase 3 or 4 and 5 with published results. The most-cited published study has 303 citations.

31Trials tracked

11Phase 3 & 4

0Recruiting

5With published results

Phase distribution

Phase 4 5 Phase 3 6 Phase 2 3 Phase 1 2 Other / NA 15

Phase 3 Oritavancin Versus IV Vancomycin for the Treatment of Participants With Acute Bacterial Skin and Skin Structure Infection (SOLO I) Completed · 303 cited
Phase 3 Oritavancin Versus IV Vancomycin for the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infection Completed · 219 cited
Phase 3 Single Dose vs. Two Dose Regimen of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Completed · 215 cited
Phase 4 A Randomized Clinical Trial Evaluating Negative Pressure Therapy to Decrease Vascular Groin Incision Complications Completed · 96 cited
Phase 4 Antimicrobial Dressing Versus Standard Dressing in Obese Women Undergoing Cesarean Delivery Completed · 4 cited
Phase 4 Prophylactic Antibiotics for Prevention of Wound Complications Following Vulvectomy Completed

Show 25 more trials

Phase 4 Comparing Outcomes for Prontosan Versus Normal Saline for Negative Pressure Wound Therapy With Instillation Completed
Phase 4 Serum and Tissue Cefazolin Concentrations in Patients Undergoing Cesarean Delivery Completed
Phase 3 Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection Completed
Phase 3 Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Completed
Phase 3 Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Completed
Phase 2 Randomized Clinical Trial of Skin Closure With Staples Versus Suture Completed
Phase 2 Insulin Complexation With Hydroxypropyl-beta-cyclodextrin: Use of the Complex in Gel for Healing of Pressure Ulcers Completed
Phase 2 StrataGraft™ Skin Tissue (Human Donor Skin) In The Surgical Management Of Complex Skin Defects Completed
Phase 1 Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients With Lower Limb Infections Completed
Phase 1 Tedizolid Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis Completed
N/A The Clinical Efficacy of Next Science Wound Gel (NXTSC) in the Healing of Chronic Wounds Completed
N/A ZIPS Study - Zip Incision aPproximation vs. Suture Completed
N/A Procellera and Negative Pressure Therapy for Acute Wounds Completed
N/A Supplemental Oxygen Reduces Surgical Infection Completed
N/A A Skin Glue Versus Subcuticular Suture for Cesarean Closure Study Completed
N/A Clinical Study to Compare 3 Multi-Layered Foam Dressings for the Management of Chronic Wounds Completed
N/A Prevention of Seroma Formation and Wound Complications Using NPWT Devices Completed
N/A Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed
N/A Effect of Peri-operative Supplemental Oxygen in Wound Infection After Appendectomy Completed
N/A Evaluation of the Effectiveness of Daily Pulse Lavage Therapy in Chronic Wounds Completed
N/A Evaluation of the Safety and Effectiveness of ALLEVYN Gentle Border Completed
N/A Negative Pressure Wound Therapy After Cesarean Delivery Completed
N/A Clinical Utility of a New Silver Gel for Use on Chronic Wounds Completed
N/A Prevena™ vs Dermabond in Groin Wound Infections in Vascular Surgery Completed
N/A Extracorporeal Shockwave Therapy for Diabetic Foot Wounds Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Chronic Wounds: what the trials found

Several interventions have been evaluated for the management of chronic wounds. These include Prevena Care ¹, ReliaTect™ Post-Op Dressing (containing chlorohexidine gluconate or CHG) ³, Cefazolin administered postoperatively [4, 6], normal saline ⁵, and single-dose IV Oritavancin Diphosphate [7, 8].

Antibiotic treatments showed specific clinical outcomes: Dalbavancin demonstrated a clinical responder rate of 81.4% to 84.2% at 48-72 hours ⁹, with various percentages of participants showing clinical status improvements at end-of-treatment and final visits ⁹. Moxifloxacin (Avelox, BAY12-8039) showed a cure rate of 80.9% to 89.6% in the per protocol population and an improvement rate of 98.3% to 99.0% during treatment days 3-5 ¹².

In trials involving single-dose IV Oritavancin Diphosphate, outcomes for cessation of spread or reduction in size of baseline lesion, absence of fever, and no rescue antibiotic medication at early clinical evaluation (48 to 72 hours) were reported as 391, 378, 84, and 101 ⁷. Additionally, investigator-assessed clinical cure for single-dose IV Oritavancin compared with IV Vancomycin for 7 to 10 days was recorded at 378, 383, 97, and 96 ⁷.

Recent results — preliminary, needs further review

Dermabond Prineo showed Patient Scar Satisfaction Scale Scores of 13 and 13.5 ².

For the clinician treating this condition

Multiple pharmacological options exist for chronic wound management, including Dalbavancin [9, 10, 11] and Oritavancin Diphosphate [7, 8].
Moxifloxin demonstrated high rates of improvement during the early treatment phase (days 3-5) ¹².
Local treatments such as ReliaTect™ Post-Op Dressing ³ and Prevena Care ¹ are established in clinical trials.

AI synthesis of 7 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.