Research across Cancer
Related studies from across the Cancer family.
Review of rectal abscess case after endoscopic mucosal resection highlights diagnostic considerations
Rectal Surgery Complication Doctors Rarely See But Must Spot Fast
This narrative review discusses a case of rectal submucosal abscess following endoscopic mucosal resection for a rectal polyp in a 74-year-o…
A 74-year-old woman developed a dangerous hidden infection after standard polyp removal, proving why doctors must recognize rare complicatio…
Neoadjuvant mFOLFOXIRI plus bevacizumab reduces peritoneal tumor burden in colorectal cancer patients
Chemo before surgery may reduce tumor burden in colorectal cancer patients
This phase II randomized controlled trial evaluated 53 patients with resectable peritoneal metastasis of colorectal cancer.
A trial suggests chemo before surgery might lower tumor markers for colorectal cancer patients with spread to the abdomen.
Early-Onset Colorectal Cancer Shows Superior Survival vs Late-Onset in Retrospective Cohort
Younger Colon Cancer Patients Live Longer After Surgery
A retrospective cohort study of 4,596 colorectal cancer patients found that early-onset disease (EOCRC) was associated with significantly be…
Even with tougher tumors, younger colon cancer patients are living longer after surgery than older patients, and doctors now have hard data …
Tumor debulking plus chemotherapy did not improve overall survival in multiorgan metastatic colorectal cancer patients
Surgery Doesn’t Extend Life for Advanced Colon Cancer
This randomized clinical trial enrolled 382 adult patients with multiorgan metastatic colorectal cancer across 27 hospitals in the Netherlan…
This large study shows that removing tumors in advanced colon cancer doesn’t help people live longer.
Global burden of early-onset colorectal cancer from alcohol, tobacco, and inactivity declined 1990-2021
More Young Adults Getting Colorectal Cancer — But One Risk Stands Out
This global cohort review analyzed early-onset colorectal cancer attributable to behavioral risk factors from 1990 to 2021.
While smoking and drinking risks drop, lack of physical activity is driving a sharp rise in colon cancer for adults under 50 worldwide.
Colonic stents versus diverting stoma for malignant left-sided colorectal obstruction show similar long-term oncologic results
Two Paths Through a Blocked Colon — Which One Is Safer?
This single-center retrospective cohort study compared 24 patients treated with colonic stents to 32 patients who underwent a diverting stom…
For a blocked colon from cancer, a temporary stent works just as well as surgery to open the bowel, getting patients to treatment faster wit…
Observational study suggests colibactin mutations are enriched in rectum regardless of polyp status
Why do some colon cancers start in the rectum while others do not?
This observational study analyzed whole-genome sequencing of colon crypts from 11 donors without polyps and 10 with polyps.
A toxin from E. coli bacteria causes specific DNA damage in the rectum, which may explain why some colon cancers start there, especially in …
Robotic simultaneous resection for synchronous colorectal cancer and liver metastases shows feasibility and safety in a meta-analysis
Robots Are Removing Colon Cancer and Liver Tumors in One Operation
This single-arm meta-analysis included 165 patients aged 18 or older with synchronous colorectal cancer and liver metastases.
Robotic surgery safely removes colon cancer and liver tumors in one operation, sparing some patients a second major procedure.
Phase I trial of regorafenib plus ipilimumab and nivolumab shows 27.6% response in MSS colorectal cancer
Who Really Responds to a Stubborn Colon Cancer Combo?
A phase I trial in 29 patients with microsatellite-stable metastatic colorectal cancer tested the combination of regorafenib, ipilimumab, an…
A three-drug combo helped some patients with stubborn colon cancer, and immune markers now predict who will benefit most.
Phase II RCT finds no OS benefit for hepatectomy in colorectal cancer with liver and lung metastases
Does removing liver tumors help when lung tumors remain? A small trial offers mixed answers
A phase II randomized trial in 27 patients with colorectal adenocarcinoma and resectable liver/unresectable lung metastases compared hepatec…
A small trial stopped early found no survival benefit for liver surgery when lung tumors remain, yet patients who actually got the operation…
Anti-EGFR rechallenge improves response and PFS but not OS in ctDNA wild-type chemorefractory mCRC
Anti-EGFR rechallenge shows benefit for some advanced colorectal cancer patients
A meta-analysis of three phase II randomized trials (n=320) in pretreated ctDNA RAS/BRAF wild-type mCRC found anti-EGFR rechallenge signific…
Giving anti-EGFR drugs again helps some advanced colorectal cancer patients shrink tumors and delay growth, though it does not extend overal…
Post hoc analysis links TMB ≥9 or BRAF-V600E to longer PFS with chemo-nivolumab in MSS/pMMR mCRC
Could two simple blood tests help predict which colon cancer patients benefit from immunotherapy?
A post hoc analysis of the METIMMOX RCT in patients with metastatic MSS/pMMR colorectal cancer found that in the experimental arm (alternati…
Two simple blood tests and tumor markers can predict which colon cancer patients live longer on immunotherapy combined with chemotherapy.