Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
Trained liver doctors provided care that matched specialists for patients with serious liver disease
A US trial found hepatologist-delivered palliative care noninferior to specialist care for improving quality of life in advanced liver disea…
Patients with advanced liver disease saw similar quality of life improvements when cared for by trained liver doctors versus specialists. Bo…
L-taurine shows no overall fatigue benefit in decompensated cirrhosis but may help non-anemic patients
Taurine for cirrhosis fatigue fails overall but helps one group
This randomized controlled trial in 220 adults with decompensated cirrhosis found no significant difference in fatigue scores with L-taurine…
Taurine did not reduce fatigue in most cirrhosis patients, but those without anemia saw meaningful improvement, suggesting a targeted approa…
Influenza vaccine induces stronger immune responses in liver cirrhosis patients
Flu Shot Works Better in Advanced Liver Disease
This prospective observational study found that patients with liver cirrhosis mount stronger humoral and cell-mediated immune responses to t…
You’re living with cirrhosis. Every cold feels dangerous.
Nurse-assisted outpatient follow-up reduces 30-day readmissions but not mortality in decompensated cirrhosis
Nurse Care Cuts Hospital Returns for Liver Patients
A meta-analysis of 668 patients with decompensated liver cirrhosis found nurse-assisted outpatient follow-up significantly reduced 30-day re…
Adding nurses to liver care teams significantly cuts 30-day hospital readmissions and improves outcomes for patients with advanced liver dis…
First-in-human study finds VS-01 generally well tolerated in decompensated cirrhosis with ascites
Early safety study of VS-01 infusion in 12 patients with advanced liver disease
This phase 1b, open-label, non-randomized study in 12 patients with decompensated cirrhosis, ascites, and covert hepatic encephalopathy foun…
A new liver treatment called VS-01 was safe for patients with advanced disease, causing mostly mild stomach issues in an early study of 12 p…
Novel nomogram predicts long-term survival after TIPS in decompensated cirrhosis
Can we better predict survival for cirrhosis patients getting TIPS treatment?
A retrospective single-center cohort study of 409 patients with decompensated cirrhosis undergoing first TIPS developed and validated a nomo…
A new prediction tool outperforms standard scores at estimating how long patients with advanced liver disease will survive after a major shu…
Research across Cirrhosis
Related studies from across the Cirrhosis family.
Total glucosides of paeony may interrupt the gut-liver axis cycle in liver cirrhosis
TGP May Improve Gut Health in Liver Cirrhosis Patients
This narrative review explores how total glucosides of paeony (TGP) may impact liver cirrhosis through the gut-liver axis. The review synthe…
New research explores how a compound called TGP may improve gut health and liver function in people with liver cirrhosis.
Salvia miltiorrhiza components show potential for hepatocyte protection and hepatic stellate cell control
Salvia miltiorrhiza shows potential for treating liver fibrosis
This narrative review examines the roles of Salvia miltiorrhiza, salvianolic acid A, and tanshinones in liver fibrosis. The review suggests …
New research explores how compounds in Salvia miltiorrhiza might protect liver cells and control the scarring process in liver fibrosis.
Surgical resection plus postoperative TACE yields recurrence-free status in rare primary clear cell liver carcinoma
Rare Liver Cancer Case Treated With Surgery and TACE
This is a case report and literature review describing a 74-year-old woman with hepatitis B-related cirrhosis and primary clear cell carcino…
A 74-year-old woman with a rare liver cancer stayed cancer-free for years after surgery plus targeted chemotherapy delivered into the liver.
Refractory ascites significantly reduces social, mental, and physical functioning in patients with advanced chronic liver disease
Refractory ascites significantly lowers quality of life for liver patients
This systematic review and meta-analysis of 1040 patients with refractory ascites found significantly lower scores in social functioning (-1…
Living with fluid buildup from advanced liver disease causes significant drops in physical, mental, and social health for both patients and …
cGAS-STING pathway serves as a central axis for innate immune activation in MASLD and HCC
New research identifies a key immune pathway in fatty liver disease
This systematic review explores the role of the cGAS-STING pathway in metabolic dysfunction-associated steatotic liver disease and hepatocel…
A specific immune pathway called cGAS-STING may play a major role in how fatty liver disease progresses and leads to serious complications.
TIPS combined with embolization reduces rebleeding risk in patients with decompensated liver cirrhosis
TIPS Combined With Embolization Reduces Rebleeding in Liver Cirrhosis
This meta-analysis of 3079 patients with decompensated liver cirrhosis and variceal bleeding found that TIPS combined with embolization sign…
Adding embolization to TIPS procedures may lower rebleeding rates and the risk of liver-related complications for patients with severe liver…
Coagulopathy and hemodialysis significantly increase odds of post-ERCP bleeding in patients with cirrhosis
Risk factors for bleeding during and after ERCP procedures identified
This meta-analysis of 149,870 patients identified several risk factors for post-ERCP bleeding. Significant associations were found for coagu…
Identifying specific risk factors like cirrhosis and blood-thinning medications helps doctors better manage bleeding risks during ERCP proce…
Statins reduce overall mortality and hepatic venous pressure gradient in patients with liver cirrhosis
Statins may lower death rates for people with liver cirrhosis
This meta-analysis of patients with liver cirrhosis indicates that statin use is associated with a significantly decreased overall mortality…
New data suggests that statins can lower death rates and certain complications for people living with liver cirrhosis.
Hepatic macrophage metabolic reprogramming and bidirectional signaling dictate the balance between liver injury and regeneration
New research identifies how liver cells communicate during chronic disease
This systematic review synthesizes the role of hepatic macrophages in metabolic dysfunction-associated steatotic liver disease, alcohol-asso…
New research reveals how specific immune cells in the liver switch between causing inflammation and repairing tissue damage.
Lactylation Targeting Shows Preclinical Anti-Fibrotic Potential in Liver Fibrosis
New Research Identifies Potential Targets for Liver Fibrosis Treatment
This narrative review examines lactylation, particularly H3K18La, as a mechanistic driver of liver fibrosis and evaluates preclinical interv…
Scientists have identified specific biological pathways and natural compounds that may help slow down the progression of liver fibrosis in e…
Transcriptomic analysis identifies 846 genes and key pathways associated with MASLD fibrosis progression
New data reveals how liver scarring progresses in fatty liver disease
This meta-analysis of hepatic transcriptomic data in approximately 1000 patients identifies 846 genes associated with MASLD fibrosis progres…
Researchers identified specific genes and cell changes that drive liver scarring in patients with metabolic dysfunction-associated steatotic…
Dioscin shows therapeutic potential for various liver disorders including MASLD and hepatocellular carcinoma
Plant Compound Dioscin Shows Promise For Liver Disease
This systematic review evaluates the hepatoprotective effects and pharmacokinetics of Dioscin in various liver diseases. The review conclude…
A plant compound called Dioscin may help protect the liver, but human evidence is still missing and high doses carry risks.