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Diabetic foot

Part of Diabetic neuropathy

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Diabetic foot

21 trials tracked for Diabetic foot: 6 in phase 3 or 4 and 2 with published results. The most-cited published study has 117 citations.

21Trials tracked
6Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 5 Phase 2 4 Other / NA 11
  1. Phase 3 Evaluate the Efficacy and Safety of ON101 Cream for the Treatment of Chronic Diabetic Foot Ulcers Completed · 117 cited
  2. Phase 3 Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers Completed · 40 cited
  3. Phase 4 Use of Santyl in Diabetic Foot Ulcers Completed
  4. Phase 3 Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers Completed
  5. Phase 3 Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection Completed
  6. Phase 3 Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis. Completed
Show 15 more trials
  1. Phase 2 Safety and Efficacy Study of DSC127 in Treating Subjects With Diabetic Ulcers Completed
  2. Phase 2 Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence Completed
  3. Phase 2 Phase 2 Pilot Trial of Subjects With Complex Non-healing Diabetic Foot Ulcers Treated With Standard Care Plus Cryopreserved Umbilical Cord Allograft (TTAX01) Completed
  4. Phase 2 BE Study of Metformin GSK 500mg Completed
  5. N/A Diabetic Foot Ulcer Study on Topical Interventions Completed
  6. N/A Less Infections for the Diabetic Foot Completed
  7. N/A Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ulcers Completed
  8. N/A TEsting for Arterial Disease in Diabetes (TrEAD) Study Completed
  9. N/A AQUACEL® Ag+ Extra™ and Cutimed™ Sorbact® Dressing in the Management of Venous Leg Ulcers Over a 12-week Period Completed
  10. N/A EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds Completed
  11. N/A Diagnostic Tools to Establish the Presence and Severity of Peripheral Arterial Disease in People With Diabetes Completed
  12. N/A Bioresorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers Completed
  13. N/A Multi-layer Insoles for a Patient-specific Approach to Shear and Pressure Reduction in Diabetes-related Foot Ulcer Completed
  14. N/A Implementation of Telemedicine for Patient With Lower Extremity Wounds Completed
  15. N/A Extracorporeal Shockwave Therapy for Diabetic Foot Wounds Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Diabetic neuropathy

Related studies from across the Diabetic neuropathy family.

Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Diabetes & Endocrinology Sys. Review
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Review of ADSC-Exos for diabetic foot ulcers lacks reported efficacy data or safety outcomes in this narrative synthesis
Diabetes & Endocrinology Sys. Review
Review of ADSC-Exos for diabetic foot ulcers lacks reported efficacy data or safety outcomes in this narrative synthesis Stem cell exosomes may help heal diabetic foot ulcers
This narrative review addresses the use of adipose-derived stem cell exosomes for diabetic foot ulcers and diabetes. The authors note that k…
A review suggests that exosomes from stem cells could improve healing for diabetic foot ulcers, offering a new treatment option.
Network meta-analysis reveals placenta-derived products significantly improve diabetic foot ulcer healing rates versus standard care options
Diabetes & Endocrinology Meta-analysis
Network meta-analysis reveals placenta-derived products significantly improve diabetic foot ulcer healing rates versus standard care options New topical treatments show strong promise for healing diabetic foot ulcers
A comprehensive network meta-analysis of 6,161 patients demonstrates that twelve topical therapies enhance wound healing in diabetic foot ul…
A major analysis of 6,161 patients found that 12 topical therapies significantly improved wound healing rates compared to standard care for …
Network meta-analysis ranks debridement strategies for venous and diabetic ulcers
Orthopedics & Sports Medicine Meta-analysis
Network meta-analysis ranks debridement strategies for venous and diabetic ulcers Biological debridement ranks highest for healing chronic leg wounds in new analysis
Biological debridement ranked highest for wound healing and complete debridement in a network meta-analysis of 25 RCTs. Enzymatic and autoly…
Biological debridement shows the highest chance of healing wounds, but experts warn the evidence has gaps and needs careful reading.
Meta-analysis finds very uncertain evidence for CO therapy in wound healing
Diabetes & Endocrinology Meta-analysis
Meta-analysis finds very uncertain evidence for CO therapy in wound healing Carbon Dioxide Therapy May Help Stubborn Wounds Heal Faster
This meta-analysis of 127 wounds/participants evaluated highly concentrated carbon dioxide therapy for diabetic foot ulcers and pressure inj…
A new review suggests highly concentrated carbon dioxide therapy may help chronic wounds heal better, but the evidence is still early.
Topical pyroligneous extract hydrogel may improve wound shrinkage in diabetic foot ulcers
Diabetes & Endocrinology RCT
Topical pyroligneous extract hydrogel may improve wound shrinkage in diabetic foot ulcers New gel may help heal diabetic foot ulcers faster than standard care
This first-in-human randomized controlled trial enrolled sixteen volunteers with diabetic foot ulcers.
A new gel with plant extract showed faster healing and fewer infections in people with diabetic foot ulcers during this first-in-human trial…
Systematic review and meta-analysis shows antifungal resistance rates vary in diabetic foot ulcer patients
Diabetes & Endocrinology Meta-analysis
Systematic review and meta-analysis shows antifungal resistance rates vary in diabetic foot ulcer patients Antifungal resistance high in diabetic foot ulcers
This systematic review and meta-analysis evaluated antifungal resistance in patients with diabetic foot ulcers.
Many diabetic foot ulcer infections resist common antifungals, especially nystatin and itraconazole.
Bayesian network meta-analysis of seven debridement approaches for diabetic foot ulcers shows low certainty evidence
Diabetes & Endocrinology Meta-analysis
Bayesian network meta-analysis of seven debridement approaches for diabetic foot ulcers shows low certainty evidence New data ranks debridement methods for healing diabetic foot ulcers faster
This Bayesian network meta-analysis evaluated seven debridement approaches versus standard wound care for individuals with diabetic foot ulc…
New research shows biological and enzymatic debridement methods shrink diabetic foot ulcers the most, but experts warn the evidence is not y…
Bibliometric analysis reveals increasing research trends in intestinal microbiota and chronic wounds
Infectious Disease Meta-analysis
Bibliometric analysis reveals increasing research trends in intestinal microbiota and chronic wounds Research shows gut health may help heal chronic wounds
This bibliometric analysis of 553 English articles examines research trends regarding intestinal microbiota and chronic wounds from 2005 to …
New research trends suggest that the bacteria in your gut could play a vital role in healing difficult wounds like diabetic foot ulcers.
C-reactive protein-to-albumin ratio predicts 6-month major adverse limb events in hospitalized diabetic foot ulcer patients
Diabetes & Endocrinology Cohort
C-reactive protein-to-albumin ratio predicts 6-month major adverse limb events in hospitalized diabetic foot ulcer patients One Blood Test Could Save Diabetic Feet From Amputation
This retrospective cohort study of 139 hospitalized patients with diabetic foot ulcers at a regional referral center in Northwest China eval…
New blood test ratio helps doctors predict which diabetic foot ulcers might lead to amputation or death within six months.
Retrospective cohort study assesses diagnostic accuracy for Wagner Grade ≥2 DFUs in hospitalized type 2 diabetes patients
Diabetes & Endocrinology Cohort
Retrospective cohort study assesses diagnostic accuracy for Wagner Grade ≥2 DFUs in hospitalized type 2 diabetes patients New Tool Predicts Severe Foot Ulcers in Diabetic Patients Before They Worsen
This retrospective cohort study evaluated diagnostic accuracy for Wagner Grade ≥2 diabetic foot ulcers (DFUs) in 510 hospitalized patients w…
This new calculator could help doctors spot dangerous foot ulcers in diabetic patients sooner, giving them a chance to act before it’s too l…
BOPPPS instruction improves vascular surgery resident outcomes in diabetic foot ulcer training compared to traditional methods
Orthopedics & Sports Medicine Cohort
BOPPPS instruction improves vascular surgery resident outcomes in diabetic foot ulcer training compared to traditional methods New teaching method improved test scores for vascular surgery residents in diabetic foot care training
This retrospective cohort study evaluated 196 vascular surgery residents at Xuanwu Hospital, Capital Medical University.
A new teaching method helped vascular surgery residents score higher on exams and perform better in diabetic foot care skills.