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Home › Conditions › Diabetic foot

Diabetic foot

Part of Diabetic neuropathy

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Diabetic foot

21 trials tracked for Diabetic foot: 6 in phase 3 or 4 and 2 with published results. The most-cited published study has 118 citations.

21Trials tracked
6Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 5 Phase 2 4 Other / NA 11
  1. Phase 3 Evaluate the Efficacy and Safety of ON101 Cream for the Treatment of Chronic Diabetic Foot Ulcers Completed · 118 cited
  2. Phase 3 Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers Completed · 40 cited
  3. Phase 4 Use of Santyl in Diabetic Foot Ulcers Completed
  4. Phase 3 Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers Completed
  5. Phase 3 Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection Completed
  6. Phase 3 Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis. Completed
Show 15 more trials
  1. Phase 2 Safety and Efficacy Study of DSC127 in Treating Subjects With Diabetic Ulcers Completed
  2. Phase 2 Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence Completed
  3. Phase 2 Phase 2 Pilot Trial of Subjects With Complex Non-healing Diabetic Foot Ulcers Treated With Standard Care Plus Cryopreserved Umbilical Cord Allograft (TTAX01) Completed
  4. Phase 2 BE Study of Metformin GSK 500mg Completed
  5. N/A Diabetic Foot Ulcer Study on Topical Interventions Completed
  6. N/A Less Infections for the Diabetic Foot Completed
  7. N/A Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ulcers Completed
  8. N/A TEsting for Arterial Disease in Diabetes (TrEAD) Study Completed
  9. N/A AQUACEL® Ag+ Extra™ and Cutimed™ Sorbact® Dressing in the Management of Venous Leg Ulcers Over a 12-week Period Completed
  10. N/A EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds Completed
  11. N/A Diagnostic Tools to Establish the Presence and Severity of Peripheral Arterial Disease in People With Diabetes Completed
  12. N/A Bioresorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers Completed
  13. N/A Multi-layer Insoles for a Patient-specific Approach to Shear and Pressure Reduction in Diabetes-related Foot Ulcer Completed
  14. N/A Implementation of Telemedicine for Patient With Lower Extremity Wounds Completed
  15. N/A Extracorporeal Shockwave Therapy for Diabetic Foot Wounds Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Diabetic foot: what the trials found

Treatment of diabetic foot ulcers with topical agents shows evidence of efficacy in reducing wound size and promoting healing. Santyl demonstrated a mean percent change in ulcer area from baseline to the end of treatment of 57.6% and 41.3% 2. Similarly, ON101 Cream showed high success rates for significant reduction, with 101% and 98% of participants achieving at least a 50% reduction in ulcer surface area 3.

Pharmacological management of infections associated with diabetic foot involves several agents. Moxifloxacin demonstrated high rates of clinical improvement during treatment (98.3% to 99.0% in the Per Protocol population) and significant cure rates at the test of cure visit (80.9% to 89.6% in the Intent to Treat population) 6. Tigecycline was also evaluated for clinical response, with various counts of patients achieving 'cure' versus 'failure' or 'indeterminate' outcomes recorded over a period of 25-27 weeks post-last dose 7.

Topical pexiganan cream 0.8% has been evaluated in multiple trials as an intervention for the condition [4, 5].

Recent results — preliminary, needs further review

  • An integrated care model was evaluated in a recent study 1.
  • AQUACEL® Ag+ Extra™ is being investigated in current clinical contexts 12.
  • Mirragen Advanced Wound Matrix showed significant results for complete wound healing (p=0.007) and significantly faster time to heal (p=0.049), though the percentage area reduction did not reach statistical significance (p=0.78) 13.
  • Telemedicine specialty consultation is being utilized as a management component 14.
  • Toe Brachial Pressure Index (TBPI) was evaluated for diagnostic accuracy with various ratios reported 15.

For the clinician treating this condition

  • Topical agents such as Santyl and ON101 Cream are established for reducing ulcer surface area [2, 3].
  • Moxifloxacin shows high rates of clinical improvement and cure in patients with associated infections 6.
  • Mirragen Advanced Wound Matrix has shown statistically significant improvements in complete wound healing and time to heal compared to other cohorts 13.

AI synthesis of 9 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Prospective observational cohort evaluates Tardivo Algorithm risk stratification and outcomes in diabetic foot patients
Diabetes & Endocrinology Cohort
Prospective observational cohort evaluates Tardivo Algorithm risk stratification and outcomes in diabetic foot patients What does a new risk tool mean for people with diabetic foot problems?
This prospective observational cohort study included 42 adult patients with diabetic foot in a vascular surgery outpatient setting.
A new risk tool tracked healing in 42 diabetic foot patients, showing 94% kept their limbs and wounds healed in about five months during rou…
Frontiers Apr 16, 2026
Higher UACR associates with Gram-negative dominance and worse inflammation in diabetic foot infections
Diabetes & Endocrinology Cohort
Higher UACR associates with Gram-negative dominance and worse inflammation in diabetic foot infections A Simple Urine Test Could Predict Your Diabetic Foot Infection
This retrospective cross-sectional observational study evaluated 325 diabetic foot infection patients from a northern Chinese tertiary hospi…
A common check for kidney health may also act as a crystal ball for foot infections, helping doctors pick the winning antibiotic from the st…
Frontiers Apr 10, 2026

Research across Diabetic neuropathy

Related studies from across the Diabetic neuropathy family.

Microbial dysbiosis impairs healing of diabetic foot ulcers through reduced diversity and biofilm formation
Diabetes & Endocrinology Sys. Review
Microbial dysbiosis impairs healing of diabetic foot ulcers through reduced diversity and biofilm formation Microbiome Balance May Help Heal Diabetic Foot Ulcers
This mini review examines the role of microbiome dysbiosis, probiotics, phage therapy, and faecal microbiota transplantation in managing dia…
Research suggests that restoring healthy bacteria and diversity in the skin and gut may help improve healing for people with diabetic foot u…
Frontiers Jul 17, 2026
Temperature-guided preventive care reduces recurrence risk in patients with diabetic foot ulcers
Primary Care & Family Medicine Meta-analysis
Temperature-guided preventive care reduces recurrence risk in patients with diabetic foot ulcers Temperature Monitoring May Reduce Recurrence of Diabetic Foot Ulcers
This meta-analysis evaluated the impact of temperature-guided preventive care compared to standard care for individuals at high risk for dia…
Monitoring skin temperature may help prevent the return of diabetic foot ulcers in high-risk patients, potentially improving long-term care …
Frontiers Jul 6, 2026
High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
Diabetes & Endocrinology Meta-analysis
High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes High rates of diabetes complications found in adult Ugandans
This meta-analysis examined the prevalence of various diabetic complications, including neuropathy and retinopathy, in a large cohort of adu…
More than half of Ugandan adults with diabetes suffer from nerve damage, highlighting a critical need for earlier screening and better care.
Jun 12, 2026
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Diabetes & Endocrinology Sys. Review
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Frontiers Jun 10, 2026
Review of ADSC-Exos for diabetic foot ulcers lacks reported efficacy data or safety outcomes in this narrative synthesis
Diabetes & Endocrinology Sys. Review
Review of ADSC-Exos for diabetic foot ulcers lacks reported efficacy data or safety outcomes in this narrative synthesis Stem cell exosomes may help heal diabetic foot ulcers
This narrative review addresses the use of adipose-derived stem cell exosomes for diabetic foot ulcers and diabetes. The authors note that k…
A review suggests that exosomes from stem cells could improve healing for diabetic foot ulcers, offering a new treatment option.
Frontiers Jun 4, 2026
Network meta-analysis reveals placenta-derived products significantly improve diabetic foot ulcer healing rates versus standard care options
Diabetes & Endocrinology Meta-analysis
Network meta-analysis reveals placenta-derived products significantly improve diabetic foot ulcer healing rates versus standard care options New topical treatments show strong promise for healing diabetic foot ulcers
A comprehensive network meta-analysis of 6,161 patients demonstrates that twelve topical therapies enhance wound healing in diabetic foot ul…
A major analysis of 6,161 patients found that 12 topical therapies significantly improved wound healing rates compared to standard care for …
May 22, 2026
Network meta-analysis ranks debridement strategies for venous and diabetic ulcers
Orthopedics & Sports Medicine Meta-analysis
Network meta-analysis ranks debridement strategies for venous and diabetic ulcers Biological debridement ranks highest for healing chronic leg wounds in new analysis
Biological debridement ranked highest for wound healing and complete debridement in a network meta-analysis of 25 RCTs. Enzymatic and autoly…
Biological debridement shows the highest chance of healing wounds, but experts warn the evidence has gaps and needs careful reading.
Frontiers May 22, 2026
Meta-analysis finds very uncertain evidence for CO therapy in wound healing
Diabetes & Endocrinology Meta-analysis
Meta-analysis finds very uncertain evidence for CO therapy in wound healing Carbon Dioxide Therapy May Help Stubborn Wounds Heal Faster
This meta-analysis of 127 wounds/participants evaluated highly concentrated carbon dioxide therapy for diabetic foot ulcers and pressure inj…
A new review suggests highly concentrated carbon dioxide therapy may help chronic wounds heal better, but the evidence is still early.
May 11, 2026
Topical pyroligneous extract hydrogel may improve wound shrinkage in diabetic foot ulcers
Diabetes & Endocrinology RCT
Topical pyroligneous extract hydrogel may improve wound shrinkage in diabetic foot ulcers New gel may help heal diabetic foot ulcers faster than standard care
This first-in-human randomized controlled trial enrolled sixteen volunteers with diabetic foot ulcers.
A new gel with plant extract showed faster healing and fewer infections in people with diabetic foot ulcers during this first-in-human trial…
May 1, 2026
Systematic review and meta-analysis shows antifungal resistance rates vary in diabetic foot ulcer patients
Diabetes & Endocrinology Meta-analysis
Systematic review and meta-analysis shows antifungal resistance rates vary in diabetic foot ulcer patients Antifungal resistance high in diabetic foot ulcers
This systematic review and meta-analysis evaluated antifungal resistance in patients with diabetic foot ulcers.
Many diabetic foot ulcer infections resist common antifungals, especially nystatin and itraconazole.
May 1, 2026
Bayesian network meta-analysis of seven debridement approaches for diabetic foot ulcers shows low certainty evidence
Diabetes & Endocrinology Meta-analysis
Bayesian network meta-analysis of seven debridement approaches for diabetic foot ulcers shows low certainty evidence New data ranks debridement methods for healing diabetic foot ulcers faster
This Bayesian network meta-analysis evaluated seven debridement approaches versus standard wound care for individuals with diabetic foot ulc…
New research shows biological and enzymatic debridement methods shrink diabetic foot ulcers the most, but experts warn the evidence is not y…
May 1, 2026
Bibliometric analysis reveals increasing research trends in intestinal microbiota and chronic wounds
Infectious Disease Meta-analysis
Bibliometric analysis reveals increasing research trends in intestinal microbiota and chronic wounds Research shows gut health may help heal chronic wounds
This bibliometric analysis of 553 English articles examines research trends regarding intestinal microbiota and chronic wounds from 2005 to …
New research trends suggest that the bacteria in your gut could play a vital role in healing difficult wounds like diabetic foot ulcers.
Frontiers Apr 30, 2026