Invasive spinal cord stimulation provides variable relief across diverse chronic neuropathic pain conditions
Different types of spinal cord stimulation help various chronic pains
This narrative review synthesizes evidence on invasive spinal cord stimulation (SCS) for various neurological and pain conditions. The autho…
Newer forms of spinal cord stimulation offer promising relief for complex nerve pain and failed back surgeries, but results vary by conditio…
Resina Draconis plus conventional therapy improves healing response in diabetic foot ulcers
Resina Draconis may speed healing for diabetic foot ulcers
This meta-analysis of randomized controlled trials evaluated Resina Draconis combined with conventional therapy for diabetic foot ulcers. Po…
Adding Resina Draconis to standard care could help heal diabetic foot ulcers faster and lower signs of inflammation in the body.
Sarcopenia doubles mortality and amputation risk in diabetic foot patients
Muscle loss increases death and amputation risks for diabetic foot
This meta-analysis of 9 studies including 2,888 individuals with diabetic foot found that sarcopenia was associated with a more than 2-fold …
Patients with a diabetic foot and muscle loss face much higher risks of severe ulcers, limb amputation, and death.
Spinal cord stimulation with medical management reduces pain intensity in painful diabetic neuropathy
Spinal Cord Stimulation Shows Promise for Diabetic Neuropathy Pain
This meta-analysis of adults with painful diabetic neuropathy found that spinal cord stimulation combined with conventional medical manageme…
Adding spinal cord stimulation to standard medical care may significantly reduce pain intensity for adults living with painful diabetic neur…
Microbial dysbiosis impairs healing of diabetic foot ulcers through reduced diversity and biofilm formation
Microbiome Balance May Help Heal Diabetic Foot Ulcers
This mini review examines the role of microbiome dysbiosis, probiotics, phage therapy, and faecal microbiota transplantation in managing dia…
Research suggests that restoring healthy bacteria and diversity in the skin and gut may help improve healing for people with diabetic foot u…
Temperature-guided preventive care reduces recurrence risk in patients with diabetic foot ulcers
Temperature Monitoring May Reduce Recurrence of Diabetic Foot Ulcers
This meta-analysis evaluated the impact of temperature-guided preventive care compared to standard care for individuals at high risk for dia…
Monitoring skin temperature may help prevent the return of diabetic foot ulcers in high-risk patients, potentially improving long-term care …
High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
High rates of diabetes complications found in adult Ugandans
This meta-analysis examined the prevalence of various diabetic complications, including neuropathy and retinopathy, in a large cohort of adu…
More than half of Ugandan adults with diabetes suffer from nerve damage, highlighting a critical need for earlier screening and better care.
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Review of ADSC-Exos for diabetic foot ulcers lacks reported efficacy data or safety outcomes in this narrative synthesis
Stem cell exosomes may help heal diabetic foot ulcers
This narrative review addresses the use of adipose-derived stem cell exosomes for diabetic foot ulcers and diabetes. The authors note that k…
A review suggests that exosomes from stem cells could improve healing for diabetic foot ulcers, offering a new treatment option.
Network meta-analysis reveals placenta-derived products significantly improve diabetic foot ulcer healing rates versus standard care options
New topical treatments show strong promise for healing diabetic foot ulcers
A comprehensive network meta-analysis of 6,161 patients demonstrates that twelve topical therapies enhance wound healing in diabetic foot ul…
A major analysis of 6,161 patients found that 12 topical therapies significantly improved wound healing rates compared to standard care for …
Network meta-analysis ranks debridement strategies for venous and diabetic ulcers
Biological debridement ranks highest for healing chronic leg wounds in new analysis
Biological debridement ranked highest for wound healing and complete debridement in a network meta-analysis of 25 RCTs. Enzymatic and autoly…
Biological debridement shows the highest chance of healing wounds, but experts warn the evidence has gaps and needs careful reading.
Meta-analysis finds very uncertain evidence for CO therapy in wound healing
Carbon Dioxide Therapy May Help Stubborn Wounds Heal Faster
This meta-analysis of 127 wounds/participants evaluated highly concentrated carbon dioxide therapy for diabetic foot ulcers and pressure inj…
A new review suggests highly concentrated carbon dioxide therapy may help chronic wounds heal better, but the evidence is still early.
Research across Diabetes
Related studies from across the Diabetes family.
Euonymus alatus may improve glucose metabolism and reduce urinary protein in diabetic nephropathy
Plant extract shows promise in managing diabetes and kidney health
This systematic review of preclinical and clinical data indicates that Euonymus alatus may lower blood glucose, reduce urinary protein, and …
A review of the plant Euonymus alatus suggests it may lower blood sugar and protect kidneys in people with diabetes.
Pharmacist-led medication therapy management improves adherence and glycemic control in a patient with complex T2DM
Pharmacist-led care improves blood sugar for woman with long-term diabetes
This case report describes a single patient with type 2 diabetes who received pharmacist-led medication therapy management. The intervention…
A pharmacist-led review helped a woman with a 30-year history of Type 2 Diabetes significantly improve her medication adherence and blood su…
Intravenous alpha-lipoic acid optimizes symptom relief while oral administration supports structural repair in DPN
Different ways to give alpha-lipoic acid help diabetic nerve pain
This Bayesian network meta-analysis evaluates various alpha-lipoic acid (ALA) administration routes for diabetic peripheral neuropathy. Find…
New data shows that intravenous and oral versions of alpha-lipoic acid offer different benefits for managing symptoms and repairing nerves i…
Microvascular alteration is a statistically significant determinant for diabetic peripheral neuropathy prevalence
New data reveals key drivers of nerve damage in diabetes
This meta-analysis of 83,560 patients across 24 countries identified a global diabetic peripheral neuropathy (DPN) prevalence of 57.42% (95%…
Over half of people with diabetes suffer from nerve damage, but new data highlights specific blood vessel changes as a primary driver of the…
Nerve decompressive surgery of the lower limbs reduces pain scores in patients with diabetic peripheral neuropathy
Nerve surgery may reduce pain for patients with diabetic neuropathy
This meta-analysis of 7 trials involving 207 patients found that nerve decompressive surgery of the lower limbs (NDSLL) significantly reduce…
New analysis shows nerve decompression surgery can lower pain scores for some people with diabetic peripheral neuropathy.
AI-OCT reports reduced false-positive DME referral rates from 69.1% to 24.1%
AI technology reduces unnecessary referrals for diabetic macular edema
This randomized clinical trial evaluated the impact of AI-OCT reports on identifying diabetic macular edema (DME) in patients with diabetes.…
New research shows that adding AI-powered imaging can significantly cut down on false alarms when screening patients for eye issues caused b…
Vitamin D supplementation shows low certainty reductions in urinary markers for diabetic kidney disease
Vitamin D shows limited benefit for diabetic kidney disease
This umbrella review meta-analysis evaluates vitamin D and its analogs in patients with diabetic kidney disease. While some reduction in uri…
Vitamin D may lower protein in urine for diabetic kidney disease, but evidence is weak and no benefit for kidney function or survival.
Balanced crystalloids reduce time to DKA resolution by 1.60 hours compared to 0.9% saline
Balanced Crystalloids May Speed Recovery in Pediatric Diabetic Ketoacidosis
This meta-analysis of 320 pediatric patients with diabetic ketoacidosis found that balanced crystalloids significantly reduced the time to D…
A review of data suggests balanced crystalloid fluids may resolve diabetic ketoacidosis faster than standard saline in children.
Early subcutaneous basal insulin plus IV insulin reduces time to DKA resolution by 4.06 hours
Early Subcutaneous Insulin Shortens Recovery Time for Diabetic Ketoacidosis
This meta-analysis of randomized controlled trials evaluated adding early subcutaneous basal insulin to intravenous insulin for adults with …
Adding early subcutaneous insulin to IV treatment can speed up recovery for patients with diabetic ketoacidosis without increasing safety ri…
Fluocinolone Acetonide Implant Shows Reduced Injection Frequency for Diabetic Macular Edema
Fluocinolone Acetonide Implant May Reduce Injection Frequency for DME
A Phase 4 trial shows fluocinolone acetonide implants achieve similar visual outcomes to aflibercept with significantly fewer total injectio…
A new eye implant for diabetic macular edema may significantly reduce the number of monthly injections needed to maintain vision.
miR-29a-3p and miR-204-5p are downregulated in diabetic nephropathy as potential biomarker candidates
Specific MicroRNA Signatures Linked to Type 1 Diabetes Complications
This systematic review and meta-analysis of 9 studies involving 34 contrasts identified specific circulating miRNA signatures associated wit…
Researchers identified specific microRNA signals that may help track kidney and eye damage in patients with Type 1 Diabetes.
Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
New research explores how inflammation drives nerve damage in diabetes
This narrative review explores the pathophysiology of diabetic peripheral neuropathy, focusing on how hyperglycemia, lipotoxicity, and intes…
Chronic high blood sugar causes more than just high glucose; it triggers a cycle of inflammation and immune stress that damages nerves.
All diabetic neuropathy Articles
- Invasive spinal cord stimulation provides variable relief across diverse chronic neuropathic pain conditions
- Resina Draconis plus conventional therapy improves healing response in diabetic foot ulcers
- Sarcopenia doubles mortality and amputation risk in diabetic foot patients
- Spinal cord stimulation with medical management reduces pain intensity in painful diabetic neuropathy
- Microbial dysbiosis impairs healing of diabetic foot ulcers through reduced diversity and biofilm formation
- Temperature-guided preventive care reduces recurrence risk in patients with diabetic foot ulcers
- High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
- Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
- Review of ADSC-Exos for diabetic foot ulcers lacks reported efficacy data or safety outcomes in this narrative synthesis
- Network meta-analysis ranks debridement strategies for venous and diabetic ulcers
- Network meta-analysis reveals placenta-derived products significantly improve diabetic foot ulcer healing rates versus standard care options
- Meta-analysis finds very uncertain evidence for CO therapy in wound healing
- Bayesian network meta-analysis of seven debridement approaches for diabetic foot ulcers shows low certainty evidence
- Topical pyroligneous extract hydrogel may improve wound shrinkage in diabetic foot ulcers
- Systematic review and meta-analysis shows antifungal resistance rates vary in diabetic foot ulcer patients
- Bibliometric analysis reveals increasing research trends in intestinal microbiota and chronic wounds
- C-reactive protein-to-albumin ratio predicts 6-month major adverse limb events in hospitalized diabetic foot ulcer patients
- Retrospective cohort study assesses diagnostic accuracy for Wagner Grade ≥2 DFUs in hospitalized type 2 diabetes patients
- Prospective observational cohort evaluates Tardivo Algorithm risk stratification and outcomes in diabetic foot patients
- BOPPPS instruction improves vascular surgery resident outcomes in diabetic foot ulcer training compared to traditional methods
- Silver/copper nanoparticle dressing shows greater wound reduction than ionic silver in infected diabetic foot ulcers
- Autologous cell therapy improved healing rates and reduced ulcer area in patients with diabetic foot ulcers compared to control
- Higher UACR associates with Gram-negative dominance and worse inflammation in diabetic foot infections
- Posterior slab cast shows higher healing rate than total contact cast for diabetic foot ulcers in single-center RCT
- Minimal offloading dressing shows similar healing rates to felted foam for plantar diabetic foot ulcers in pilot trial