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Home › Conditions › Diabetic Foot Ulcers

Diabetic Foot Ulcers

Part of Diabetic neuropathy

15 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Diabetic Foot Ulcers

61 trials tracked for Diabetic Foot Ulcers: 16 in phase 3 or 4 and 3 with published results. The most-cited published study has 63 citations.

61Trials tracked
16Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 8 Phase 3 8 Phase 2 9 Other / NA 36
  1. Phase 4 Efficacy and Safety of Garamycin® Sponge in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection Completed · 63 cited
  2. Phase 3 VA MERIT: A Comparative Efficacy Study: Treatment of Non-Healing Diabetic Completed · 62 cited
  3. Phase 3 Phase 3 Study to Evaluate the Safety and Efficacy of Galnobax® in Treating Diabetic Foot Ulcers Completed · 22 cited
  4. Phase 4 GrafixPL PRIME Evaluation Case Study Completed
  5. Phase 4 Using Santyl on Diabetic Foot Ulcers Completed
  6. Phase 4 Study of Oasis Ultra in Diabetic Foot Ulcers Completed
Show 44 more trials
  1. Phase 4 Enzymatic Versus (vs) Autolytic Debridement of Diabetic Foot Ulcers Completed
  2. Phase 4 Wound Edge Changes Following Treatment With Santyl Completed
  3. Phase 4 Santyl vs. Sharp Debridement of Diabetic Foot Wounds Completed
  4. Phase 4 A Study to Look at the Effects of Four Weeks of Treatment on the Healing of Diabetic Foot Ulcers Completed
  5. Phase 3 Efficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot Ulcers Completed
  6. Phase 3 Comparative Effectiveness of Two Acellular Matrices (Dermacell vs. Integra) for Management of Deep Diabetic Foot Ulcers Completed
  7. Phase 3 The Effect Of Fragmin In The Treatment Of Neuroischaemic Foot Ulcers In Diabetic Patients (A6301086) Completed
  8. Phase 3 Transdermal Continuous Oxygen Therapy for Diabetic Foot Ulcers Completed
  9. Phase 3 Effectiveness of dermaPACE™ Device and Standard Treatment Compared to Standard Treatment Alone for Diabetic Foot Ulcers Completed
  10. Phase 3 Study Of The Effect Of Fragmin In The Treatment Of Neuroischaemic Foot Ulcers In Diabetic Patients Completed
  11. Phase 2 Clinical Investigation of Galnobax® for the Treatment of Diabetic Foot Ulcers Completed
  12. Phase 2 The Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With Moderately Infected Foot Ulcers Completed
  13. Phase 2 TWB-103 for Treating Lower Limb Ulcers on Patients With DM Completed
  14. Phase 2 Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers Completed
  15. Phase 2 Preventing Diabetic Foot Ulcers Through Cleaner Feet Completed
  16. Phase 2 Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With a Mild Infection of a Foot Ulcer Completed
  17. Phase 2 Novel Offloading for Diabetic Foot Ulcers With PulseFlow: A Prospective Study Completed
  18. Phase 2 Herbal Preparation Used as Adjuvant Therapy on Diabetic Ulcers Completed
  19. Phase 2 CSTC1 for Diabetic Foot Ulcers Phase II Study Completed
  20. N/A Evaluating the Ease of Use of a VAC GranuFoam Bridge Dressing on Diabetic Foot Ulcers Receiving VAC Negative Pressure Wound Therapy Completed
  21. N/A Clinical Performance and Cost Effectiveness of Biatain® Silicone Compared With Standard of Care Completed
  22. N/A Instant Total Contact Cast to Heal Diabetic Foot Ulcers Completed
  23. N/A LeucoPatch™ Study A Multicenter Study on the Effect of LeucoPatch™ in Diabetic Foot Ulcers Completed
  24. N/A Acellular Porcine Dermal Matrix Wound Dressing in the Management of Diabetic Foot Ulcers Completed
  25. N/A A Non-significant Risk Clinical Study of Therapeutic Ultrasound for Patients With Diabetic Foot Ulcers. Completed
  26. N/A Electrical Stimulation to Accelerate Wound Healing Completed
  27. N/A MIRODERM H2H DFU Study Completed
  28. N/A The Effect of Natrox® Oxygen Wound Therapy on the Healing Rate of Chronic Diabetic Foot Ulcers Completed
  29. N/A Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT) Completed
  30. N/A A Prospective, Randomized, Double-Blind Multicenter Study Comparing CDO Therapy to Standard MWT in the Treatment of DFUs Completed
  31. N/A CO2-Laser Treatment in Patients With Diabetic Infected Foot Ulcers Completed
  32. N/A Evaluation Of An Advanced Borderless Dressing Completed
  33. N/A Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers Completed
  34. N/A Efficacy, Safety and Economic Benefits of Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers Completed
  35. N/A TEsting for Arterial Disease in Diabetes (TrEAD) Study Completed
  36. N/A Clinical Study to Compare 3 Multi-Layered Foam Dressings for the Management of Chronic Wounds Completed
  37. N/A Clinical Outcomes After Treatment With RestrataTM Wound Matrix in Diabetic Foot Ulcers (DFU) Completed
  38. N/A Efficacy of Laser Debridement on Pain and Bacterial Load in Chronic Wounds Completed
  39. N/A Open, Non-comparative, Multi-centre Post Marketing Clinical Follow-up Investigation to Evaluate Performance and Safety on Diabetic Foot Ulcer, DFU When Using Fast Gelling Dressing as Intended. Completed
  40. N/A Characterization of AmnioExcel Plus in Two Treatment Paradigms Completed
  41. N/A Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers Completed
  42. N/A Improving DFU Outcomes: Early Detection of Foot Ulcers Using Novel Technology Completed
  43. N/A PriMatrix for the Management of Diabetic Foot Ulcers Completed
  44. N/A TITLE: An Open, Non-comparative, Multi-centre Post Marketing Clinical Follow-up (PMCF) Investigation to Evaluate Performance and Safety on Diabetic Foot Ulcer, DFU, When Using Mepilex Transfer Ag as Intended Completed

Showing the 50 most-cited and recently-updated of 61 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Silver/copper nanoparticle dressing shows greater wound reduction than ionic silver in infected diabetic foot ulcers
Diabetes & Endocrinology RCT
Silver/copper nanoparticle dressing shows greater wound reduction than ionic silver in infected diabetic foot ulcers Small pilot study finds silver-copper dressing may reduce wound size in diabetic foot ulcers
A small pilot RCT of 30 patients with infected diabetic foot ulcers compared silver/copper nanoparticle dressings to ionic silver dressings.
A new silver-copper dressing shrank infected diabetic foot ulcers by 43% in just one week, outperforming standard silver dressings in a smal…
Apr 13, 2026
Posterior slab cast shows higher healing rate than total contact cast for diabetic foot ulcers in single-center RCT
Diabetes & Endocrinology RCT
Posterior slab cast shows higher healing rate than total contact cast for diabetic foot ulcers in single-center RCT Posterior slab cast may heal diabetic foot ulcers faster than total contact cast in small trial
A single-center, open-label RCT of 99 adults with Type 2 diabetes and plantar diabetic foot ulcers compared posterior slab cast (PSC) to tot…
A new cast type helped more diabetic foot wounds heal in six months compared to the standard method in a small trial.
Apr 8, 2026
Minimal offloading dressing shows similar healing rates to felted foam for plantar diabetic foot ulcers in pilot trial
Diabetes & Endocrinology RCT
Minimal offloading dressing shows similar healing rates to felted foam for plantar diabetic foot ulcers in pilot trial Can a simpler dressing help heal diabetic foot ulcers as well as standard care?
A pilot RCT of 40 patients with plantar diabetic foot ulcers found similar 12-week healing rates between minimal offloading dressing (95%) a…
A simpler diabetic foot dressing healed 95% of wounds faster than standard foam, though the study was small and results weren't statisticall…
Apr 3, 2026

Research across Diabetic neuropathy

Related studies from across the Diabetic neuropathy family.

Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Diabetes & Endocrinology Sys. Review
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Frontiers Jun 10, 2026
Prospective observational cohort evaluates Tardivo Algorithm risk stratification and outcomes in diabetic foot patients
Diabetes & Endocrinology Cohort
Prospective observational cohort evaluates Tardivo Algorithm risk stratification and outcomes in diabetic foot patients What does a new risk tool mean for people with diabetic foot problems?
This prospective observational cohort study included 42 adult patients with diabetic foot in a vascular surgery outpatient setting.
A new risk tool tracked healing in 42 diabetic foot patients, showing 94% kept their limbs and wounds healed in about five months during rou…
Frontiers Apr 16, 2026
Higher UACR associates with Gram-negative dominance and worse inflammation in diabetic foot infections
Diabetes & Endocrinology Cohort
Higher UACR associates with Gram-negative dominance and worse inflammation in diabetic foot infections A Simple Urine Test Could Predict Your Diabetic Foot Infection
This retrospective cross-sectional observational study evaluated 325 diabetic foot infection patients from a northern Chinese tertiary hospi…
A common check for kidney health may also act as a crystal ball for foot infections, helping doctors pick the winning antibiotic from the st…
Frontiers Apr 10, 2026

Questions about Diabetic Foot Ulcers

Did autologous cell therapy improve healing rates for diabetic foot ulcers?

Autologous cell therapy significantly improved healing rates and reduced ulcer area in patients with diabetic foot ulcers compared to standard care.

Full answer →
How do we accurately diagnose severe diabetic foot ulcers in hospitals?

Diagnosing severe diabetic foot ulcers in hospitals involves clinical exam, imaging, lab tests (CRP/albumin ratio, CBC), and advanced tools like nomograms and microbiome sequencing to assess infection, ischemia, and prognosis.

Full answer →
Can a blood test predict major limb events for diabetic foot ulcers?

Yes, the C-reactive protein-to-albumin ratio (CAR) blood test can help predict major limb events in diabetic foot ulcer patients within 6 months.

Full answer →
Do diabetic foot ulcers often have antifungal resistance?

Yes, diabetic foot ulcers often show antifungal resistance, especially to fluconazole and itraconazole, though rates vary by drug and region.

Full answer →