Early-Onset Colorectal Cancer Shows Superior Survival vs Late-Onset in Retrospective Cohort
Younger Colon Cancer Patients Live Longer After Surgery
A retrospective cohort study of 4,596 colorectal cancer patients found that early-onset disease (EOCRC) was associated with significantly be…
Even with tougher tumors, younger colon cancer patients are living longer after surgery than older patients, and doctors now have hard data …
Global burden of early-onset colorectal cancer from alcohol, tobacco, and inactivity declined 1990-2021
More Young Adults Getting Colorectal Cancer — But One Risk Stands Out
This global cohort review analyzed early-onset colorectal cancer attributable to behavioral risk factors from 1990 to 2021.
While smoking and drinking risks drop, lack of physical activity is driving a sharp rise in colon cancer for adults under 50 worldwide.
Observational study suggests colibactin mutations are enriched in rectum regardless of polyp status
Why do some colon cancers start in the rectum while others do not?
This observational study analyzed whole-genome sequencing of colon crypts from 11 donors without polyps and 10 with polyps.
A toxin from E. coli bacteria causes specific DNA damage in the rectum, which may explain why some colon cancers start there, especially in …
Research across Cancer
Related studies from across the Cancer family.
Review of rectal abscess case after endoscopic mucosal resection highlights diagnostic considerations
Rectal Surgery Complication Doctors Rarely See But Must Spot Fast
This narrative review discusses a case of rectal submucosal abscess following endoscopic mucosal resection for a rectal polyp in a 74-year-o…
A 74-year-old woman developed a dangerous hidden infection after standard polyp removal, proving why doctors must recognize rare complicatio…
AI-Assisted Colonoscopy Improves Right-Sided Adenoma Detection in Gastroenterology Fellows
AI helps trainee doctors find more polyps in colonoscopies
This pragmatic randomized controlled trial assigned 16 gastroenterology fellows to AI-enhanced or conventional colonoscopy for 1045 procedur…
AI-assisted colonoscopy helped gastroenterology fellows detect more polyps on the right side of the colon, a hard-to-see area.
Neoadjuvant mFOLFOXIRI plus bevacizumab reduces peritoneal tumor burden in colorectal cancer patients
Chemo before surgery may reduce tumor burden in colorectal cancer patients
This phase II randomized controlled trial evaluated 53 patients with resectable peritoneal metastasis of colorectal cancer.
A trial suggests chemo before surgery might lower tumor markers for colorectal cancer patients with spread to the abdomen.
Tumor debulking plus chemotherapy did not improve overall survival in multiorgan metastatic colorectal cancer patients
Surgery Doesn’t Extend Life for Advanced Colon Cancer
This randomized clinical trial enrolled 382 adult patients with multiorgan metastatic colorectal cancer across 27 hospitals in the Netherlan…
This large study shows that removing tumors in advanced colon cancer doesn’t help people live longer.
Colonic stents versus diverting stoma for malignant left-sided colorectal obstruction show similar long-term oncologic results
Two Paths Through a Blocked Colon — Which One Is Safer?
This single-center retrospective cohort study compared 24 patients treated with colonic stents to 32 patients who underwent a diverting stom…
For a blocked colon from cancer, a temporary stent works just as well as surgery to open the bowel, getting patients to treatment faster wit…
Observational study links inherited genetic variants to young-onset lung cancer risk
Lung Cancer Before 45: New Study Reveals Hidden Genetic Clues
This primary research article reports an observational analysis of 9,065 patients, finding that rare pathogenic germline variants in DNA dam…
Lung cancer before 45 often stems from rare inherited gene flaws in DNA repair and immune systems, giving families clearer answers about thi…
Robotic simultaneous resection for synchronous colorectal cancer and liver metastases shows feasibility and safety in a meta-analysis
Robots Are Removing Colon Cancer and Liver Tumors in One Operation
This single-arm meta-analysis included 165 patients aged 18 or older with synchronous colorectal cancer and liver metastases.
Robotic surgery safely removes colon cancer and liver tumors in one operation, sparing some patients a second major procedure.
Phase I trial of regorafenib plus ipilimumab and nivolumab shows 27.6% response in MSS colorectal cancer
Who Really Responds to a Stubborn Colon Cancer Combo?
A phase I trial in 29 patients with microsatellite-stable metastatic colorectal cancer tested the combination of regorafenib, ipilimumab, an…
A three-drug combo helped some patients with stubborn colon cancer, and immune markers now predict who will benefit most.
Phase II RCT finds no OS benefit for hepatectomy in colorectal cancer with liver and lung metastases
Does removing liver tumors help when lung tumors remain? A small trial offers mixed answers
A phase II randomized trial in 27 patients with colorectal adenocarcinoma and resectable liver/unresectable lung metastases compared hepatec…
A small trial stopped early found no survival benefit for liver surgery when lung tumors remain, yet patients who actually got the operation…
Anti-EGFR rechallenge improves response and PFS but not OS in ctDNA wild-type chemorefractory mCRC
Anti-EGFR rechallenge shows benefit for some advanced colorectal cancer patients
A meta-analysis of three phase II randomized trials (n=320) in pretreated ctDNA RAS/BRAF wild-type mCRC found anti-EGFR rechallenge signific…
Giving anti-EGFR drugs again helps some advanced colorectal cancer patients shrink tumors and delay growth, though it does not extend overal…
Post hoc analysis links TMB ≥9 or BRAF-V600E to longer PFS with chemo-nivolumab in MSS/pMMR mCRC
Could two simple blood tests help predict which colon cancer patients benefit from immunotherapy?
A post hoc analysis of the METIMMOX RCT in patients with metastatic MSS/pMMR colorectal cancer found that in the experimental arm (alternati…
Two simple blood tests and tumor markers can predict which colon cancer patients live longer on immunotherapy combined with chemotherapy.
FDA Approves Krazati (adagrasib) for KRAS G12C-Mutated NSCLC and in Combination for Colorectal Cancer
FDA approves a new targeted cancer drug called Krazati for lung and colorectal cancers
The FDA has approved Krazati as a single agent for adult patients with KRAS G12C-mutated locally advanced or metastatic NSCLC after at least…
FDA approves Krazati, a new targeted drug for lung and colorectal cancers with a specific genetic change after other treatments fail.