Research across Septic Shock
Related studies from across the Septic Shock family.
Impact of Early Vasopressor Therapy and Restricted Fluids in Septic Shock Management
Early Vasopressors for Septic Shock: Fewer Fluids, Same Survival
A large-scale randomized trial evaluates if early vasopressors and restricted fluids improve survival outcomes in patients with septic shock…
Giving septic shock patients less fluid and vasopressors sooner cut dangerous lung fluid buildup, but didn't extend survival.
Higher H3.1 nucleosome levels associate with 48% increased 28-day mortality in septic shock
H3.1 Nucleosome Levels Linked to Sepsis Mortality and Kidney Risk
This secondary analysis of a multicenter randomized controlled trial involved 971 patients with sepsis and septic shock. Higher plasma H3.1 …
Higher levels of H3.1 nucleosomes in patients with sepsis and septic shock are linked to a higher risk of death and need for kidney replacem…
Point-of-care ultrasound supports source identification and physiologic reassessment in patients with sepsis and septic shock
Ultrasound helps doctors identify infection sources in sepsis patients
This narrative review examines the role of point-of-care ultrasound (POCUS) for source-oriented assessment and physiologic reassessment in e…
Point-of-care ultrasound can help emergency doctors find infection sources and monitor fluid levels in patients with life-threatening sepsis…
Precision-oriented resuscitation for septic shock emphasizes titrated fluid therapy and individualized vasopressor management
New precision approach aims to improve care for septic shock
This narrative review explores a precision-oriented approach to septic shock involving titrated fluid therapy, individualized vasopressor su…
Doctors are moving toward a precision approach for septic shock that focuses on individual patient needs rather than using a one size fits a…
Anisodamine hydrobromide plus standard therapy reduces 28-day mortality in septic shock (hazard ratio 0.64)
Anisodamine hydrobromide reduces death rates in patients with septic shock
This randomized controlled trial of 296 patients with septic shock found that anisodamine hydrobromide plus standard therapy significantly r…
A new trial shows that adding anisodamine hydrobromide to standard care significantly lowers the risk of death for patients in septic shock.
Intravenous vitamin C associated with reduced mortality in patients with sepsis and septic shock
Vitamin C May Reduce Mortality in Patients with Sepsis
This meta-analysis evaluated the impact of intravenous vitamin C on outcomes for patients with sepsis or septic shock. The authors observed …
A review of data suggests intravenous vitamin C may lower death rates for patients with sepsis, though the evidence quality remains low.
Early vasopressin initiation in septic shock shows mixed mortality outcomes across different study designs
Early Vasopressin Initiation May Help Patients with Septic Shock
This meta-analysis of 15 studies evaluates early vasopressin initiation in adults with septic shock. While observational studies suggest low…
Early use of vasopressin in septic shock patients may link to better outcomes, though results vary significantly depending on the type of st…
Elevated syndecan-1 levels correlate with severity and poor outcomes in patients with sepsis
Higher syndecan-1 levels linked to severe sepsis and poor outcomes
This meta-analysis of 4985 patients, including 3902 with sepsis, found significantly higher circulating syndecan-1 levels in sepsis patients…
A new analysis shows that higher levels of a specific protein can help doctors identify patients with the most severe forms of sepsis.
Low-dose corticosteroids reduce 90-day mortality in adults with severe community-acquired pneumonia
Low dose steroids may lower death rates in severe lung infections
This meta-analysis of 4,622 patients found that low-dose corticosteroids (≤400 mg hydrocortisone-equivalent daily) significantly reduced sho…
A review of clinical trials suggests that low-dose corticosteroids can reduce 90-day mortality for adults with severe lung infections like p…
IgM-enriched immunoglobulin shows directionally favorable but statistically inconclusive results for short-term mortality in sepsis
IgM Therapy for Sepsis Shows Promise but Not Proof
This meta-analysis of 411 adults with sepsis or septic shock found that IgM-enriched immunoglobulin (Pentaglobin) showed a favorable trend f…
A new analysis hints IgM therapy may lower sepsis deaths, but the evidence isn't strong enough to recommend it yet.
Skin perfusion parameters Mottling Score, CRT, and PPI correlate with higher mortality in sepsis patients
Skin Perfusion Markers Linked to Higher Sepsis Mortality Risk
This meta-analysis of 22 articles involving 2,727 subjects indicates that skin perfusion markers are associated with increased mortality ris…
Specific skin signs like mottling and slow capillary refill may help doctors identify patients with sepsis who are at a higher risk of death…
Arterial hypotension is a late sign of decompensated shock linked to increased mortality and adverse neurologic outcomes in critically ill children
Low blood pressure in sick kids signals danger and needs careful management
This guideline narrative review addresses arterial hypotension, septic shock, and traumatic brain injury in critically ill infants and child…
Low blood pressure in critically ill children often means shock is worsening. Experts now suggest aiming for targets at least at the 10th pe…