Bayesian network meta-analysis compares CGRP therapies for episodic migraine
New migraine drugs show big benefits over placebo for monthly attack counts
This Bayesian network meta-analysis synthesized evidence on six CGRP-targeted therapies for episodic migraine. It found that monoclonal anti…
New migraine drugs cut monthly attacks more than placebo, with injectables slightly better than pills for some people.
Preliminary Italian data show intravenous eptinezumab reduces pain and symptoms in patients with ongoing episodic or chronic migraine attacks
The Big Discovery:** A preventive migraine drug can start easing pain and light sensitivity during an ongoing attack—in as little as 10 minutes
This preliminary observational study enrolled 31 patients with episodic or chronic migraine experiencing an ongoing attack in an Italian rea…
For the first time, real-world data shows a migraine prevention treatment can also act with surprising speed to stop an attack that’s alread…
Resting-state fMRI shows reduced brain entropy in episodic and chronic migraine compared to healthy controls
Brain entropy changes in migraine patients compared to healthy controls
This resting-state fMRI study examined brain entropy in adults with episodic migraine, chronic migraine, and healthy controls.
Migraine patients show lower brain complexity in key networks compared to healthy controls, with the biggest drop seen in chronic cases.
Research across Migraine
Related studies from across the Migraine family.
Neurotological evaluation distinguishes vestibular migraine from viral neuritis in acute unilateral vestibulopathy
A single case report shows rapid recovery in vestibular migraine
This case report describes a 40-year-old woman with a history of migraine with aura presenting to the emergency department with vestibular m…
A 40-year-old woman with vestibular migraine recovered her balance quickly. This case suggests that specific reflex patterns help doctors te…
Post-marketing data on CGRP inhibitors show paucity of data and additional risks from chronic biologic use
Post-marketing review highlights safety gaps for migraine CGRP drugs
This narrative review examines monoclonal antibodies and Calcitonin Gene-Related Peptide (CGRP) inhibitors for migraine in the post-marketin…
A review of migraine treatments notes limited data on long-term risks for CGRP inhibitors, urging caution during active monitoring.
Asia-Pacific experts reach consensus on migraine management and anti-CGRP mAb use in adolescents
Asia-Pacific experts find consensus on migraine diagnosis and treatment
This guideline presents a Delphi consensus involving 14 headache specialists from seven Asia-Pacific countries. The group evaluated statemen…
Headache specialists across Asia-Pacific agree on key migraine diagnosis and treatment steps, favoring anti-CGRP drugs for most patients but…
Narrative review refutes causal link between endometriosis and migraine
Endometriosis and Migraine Share Hidden Genetic Roots
This narrative review examines the association between endometriosis and migraine. The authors refute a causal relationship and discuss shar…
New genetic research suggests endometriosis and migraine are parallel conditions driven by shared inflammatory pathways, not just hormones.
Systematic review and meta-analysis compares Rome III and Rome IV criteria for functional abdominal pain disorder prevalence
New Rome IV rules show fewer people have functional abdominal pain compared to older guidelines
This systematic review and meta-analysis evaluates the prevalence of functional abdominal pain disorder (FAPD) and its subtypes using Rome I…
A big review found that using newer rules makes it look like fewer people have stomach pain problems. This change happens because the new ch…
Meta-analysis of Chinese decoctions for migraine shows varied efficacy rankings across three botanical interventions.
New analysis ranks best herbal treatments for migraine pain
This Bayesian network meta-analysis synthesizes data from 57 randomized controlled trials involving 6,005 patients with migraine.
A new analysis of dozens of Chinese herbal formulas reveals which ones may ease migraine pain, frequency, and duration better than others, o…
Individualized probabilistic migraine forecasts delivered via electronic diaries in adults with recurrent headaches
Migraine Forecasting Just Got Smarter
This prospective cohort study of 230 adults with recurrent migraine or tension-type headache evaluated individualized probabilistic forecast…
This tool could help you prepare for migraines before they strike.
Observational cohort study on smartphone-based cognitive assessment during migraine attacks
At-a-Glance
This primary research article is an observational cohort study of 139 adults with migraine using smartphone-based cognitive tasks.
This study proves that your brain's processing speed and memory can dip during a migraine attack, and a simple smartphone app can now track …
Feasibility of 30-day smartphone assessment in 177 adults with migraine
Smartphones Track Migraine Brain Fog Better Than Doctor Visits
This cohort study assessed the feasibility of a 30-day smartphone-based assessment involving once-daily ecological momentary assessments and…
Imagine trying to remember your keys during a severe migraine.
Add-on atogepant 60 mg daily reduced monthly migraine days in chronic migraine patients on stable onabotulinumtoxinA
Adding atogepant to botulinum toxin reduced migraine days in a small study
This Phase 3, multicenter, 24-week, open-label, single arm study evaluated add-on atogepant 60 mg once daily in 75 participants with chronic…
Adding atogepant to botulinum toxin cut migraine days by over 50% for 62% of patients in a study, with most finding it safe and well-tolerat…
Narrative review explores fMRI utility in otolaryngology disorders including tinnitus and vestibular migraine
The Brain Scan Changing How Doctors See Hearing and Balance Problems
This narrative review examines the application of functional magnetic resonance imaging (fMRI) in patients with otolaryngology–head and neck…
A new brain scan shows that tinnitus and hearing loss aren't just ear problems, but actually change how the brain works.
Senkyunolides show promise for migraine but face stability challenges requiring further development
New Hope for Migraine Sufferers
A systematic review evaluated senkyunolides as potential migraine treatments, noting their promising pharmacological mechanisms and homeosta…
Senkyunolides from traditional herbs cross the brain's strict security guard to calm pain nerves and protect cells without the heart risks o…
Questions about Episodic Migraine
Does resting-state fMRI show lower brain entropy in episodic migraine than in healthy people?
Yes, resting-state fMRI studies show that people with episodic migraine have lower brain entropy in key brain networks compared to healthy people.
Full answer →Do gepants help reduce monthly migraines in patients with episodic migraine?
Oral gepants like rimegepant and atogepant reduce monthly migraine days in episodic migraine, with rimegepant showing sustained benefits up to 52 weeks in trials.
Full answer →Does intravenous eptinezumab help reduce pain during an ongoing episodic migraine attack?
Intravenous eptinezumab can reduce pain and symptoms during an ongoing episodic migraine attack, with improvements seen within the first 10 to 20 minutes of infusion.
Full answer →