Research across Cancer
Related studies from across the Cancer family.
Transrectal Ultrasound Characterization of Rectal Neuroendocrine Neoplasms Shows Feasibility in Small Retrospective Cohort
Doctors use ultrasound to map rare rectal tumors before surgery
This retrospective case analysis evaluated transrectal ultrasound and contrast-enhanced ultrasound in 17 patients with rectal neuroendocrine…
A new ultrasound method helps doctors map rare rectal tumors before surgery to plan better treatment plans for patients today
Retrospective analysis finds sarcopenia associated with shorter disease-free survival in pancreatic neuroendocrine tumor patients
Low muscle mass linked to shorter disease-free survival in pancreatic tumor patients
This retrospective cohort study included 86 patients who underwent curative-intent resection for pancreatic neuroendocrine tumors.
Low muscle mass before surgery was linked to shorter disease-free survival in patients with pancreatic neuroendocrine tumors, though this li…
Nivolumab plus ipilimumab versus nivolumab in advanced neuroendocrine carcinoma phase II trial
New Combo Shows Modest Promise for Hard-to-Treat Neuroendocrine Cancers
This randomized phase II trial enrolled 185 patients with advanced neuroendocrine carcinoma refractory to platinum-based chemotherapy.
For patients with rare, aggressive neuroendocrine cancers that resist initial treatment, this study offers a new, though modest, combination…
Phase II RCT finds no benefit for adding capecitabine to 177Lu-Dotatate in advanced NETs
Adding a Drug Actually Hurted These Patients
A Phase II randomized controlled trial in 111 patients with advanced somatostatin receptor-positive GEP or bronchopulmonary NETs compared…
Adding a common chemotherapy drug to cancer treatment actually made tumors grow faster and reduced survival time for these patients.
Meta-analysis of splenic-preserving vs splenectomy distal pancreatectomy for resectable body/tail pNETs
Meta-analysis suggests splenic-preserving surgery may reduce complications for certain pancreatic tumors
This systematic review and meta-analysis evaluated splenic-preserving distal pancreatectomy (SPDP) versus distal pancreatectomy with splenec…
Keeping the spleen during pancreatic surgery led to less blood loss, fewer complications, shorter hospital stays, and lower transfusion need…
Comprehensive geriatric assessment modifies treatment plans and associates with survival in older adults with gastrointestinal malignancies
Does a pre-surgery check-up actually change treatment plans and help older adults with cancer live longer?
This retrospective cohort study evaluated 273 adults aged ≥65 years referred for preoperative comprehensive geriatric assessment (CGA) at a …
A pre-surgery health check changed treatment plans for 21% of older cancer patients and was linked to better survival.
![In a phase 2 trial, [Ga]Ga-SSO120 PET/CT detected malignancies in 18 of 19 patients with small cell or large cell neuroendocrine lung cancer](https://images.unsplash.com/photo-1766297247924-6638d54e7c89?crop=entropy&cs=tinysrgb&fit=max&fm=jpg&ixid=M3w5MDg5NDR8MHwxfHNlYXJjaHw5fHxtZWRpY2FsJTIwcmVzZWFyY2glMjBzY2llbmNlfGVufDF8MHx8fDE3NzU4ODUyMzd8MA&ixlib=rb-4.1.0&q=80&w=1080)
In a phase 2 trial, [Ga]Ga-SSO120 PET/CT detected malignancies in 18 of 19 patients with small cell or large cell neuroendocrine lung cancer
A New Scan That Lights Up Hidden Lung Cancer Spread
This prospective, phase 2, cross-sectional imaging trial evaluated [Ga]Ga-SSO120 PET/CT versus CT in 19 patients with small cell lung cancer…
A new kind of PET scan found hidden tumors in patients with aggressive lung cancer, including bone and brain spread that standard imaging mi…
Systematic review examines HIF-1α role in digestive system inflammation and cancer
Could a single protein be fueling both gut inflammation and cancer?
A systematic review synthesizing existing literature found HIF-1α contributes to pathogenesis of inflammatory digestive diseases and promote…
A single protein called HIF-1α may be driving both gut inflammation and digestive cancers while helping tumors resist drugs and evade the im…
H2H nutrition management improves PG-SGA scores in malnourished GI cancer patients on chemotherapy
Can better nutrition management help cancer patients fight fatigue and stay stronger during chemo?
A 100-patient RCT in gastric/colorectal cancer patients with malnutrition risk (PG-SGA ≥2) found that whole-cycle nutrition management based…
A new nutrition plan for stomach and colon cancer patients during chemo improved strength, reduced fatigue, and boosted quality of life comp…
Phase 1b/2 study of ERAS-007 combinations in advanced GI malignancies completes enrollment of 101 patients
Can a new drug combination help people with advanced colorectal or pancreatic cancer?
A Phase 1b/2 platform study evaluated ERAS-007 in combination with other cancer therapies in patients with advanced gastrointestinal maligna…
A new drug combination tested in advanced colorectal and pancreatic cancer aims to find safe doses and early signs of tumor shrinkage in pat…
Axitinib + Octreotide Shows PFS Benefit in Extrapancreatic NETs per Central Review (HR 0.71)
Can a blood vessel blocker help slow rare gut tumors? Study shows mixed results for new combination treatment
In the AXINET phase II/III trial, axitinib plus octreotide LAR significantly improved median PFS per blinded independent central review (16.…
A new blood vessel blocker combined with standard hormone shots helped rare gut tumors shrink and delayed growth longer than placebo, despit…