Research across Epilepsy
Related studies from across the Epilepsy family.
28% recurrence rate after antiseizure medication withdrawal in children with epilepsy
Stopping seizure meds in children: 28% recurrence risk
This meta-analysis of 3,226 children with epilepsy found a pooled recurrence rate of 28% (95% CI: 23%–33%) after antiseizure medication with…
About 28% of children with epilepsy who stop antiseizure medications will have a seizure return. Several factors can increase this risk.
MRgLITT provides comparable QALYs to open resection for children with drug-resistant focal epilepsy
Laser surgery shows better survival for children with drug-resistant epilepsy
This systematic review utilizes a Markov decision analytic model to compare MRgLITT and open resective surgery against medical management in…
A new analysis suggests laser surgery can offer a 4.6 year survival advantage over medical management for children with certain types of epi…
Exercise training promotes adult hippocampal neurogenesis by influencing the neurochemical environment and cell cycle dynamics
Exercise training may help grow new neurons in the brain
This narrative review synthesizes evidence regarding exercise training and its effects on adult hippocampal neurogenesis in conditions such …
Physical exercise can trigger the growth of new neurons and stem cells, potentially offering new paths for treating brain disorders like Alz…
Longer epilepsy duration correlates with significantly lower DTI-ALPS index scores across multiple epilepsy subtypes
Longer Epilepsy Duration Linked to Lower Glymphatic Function
This meta-analysis of 449 patients found a significant negative association between epilepsy duration and the DTI-ALPS index, suggesting imp…
Research suggests that the length of time a person lives with epilepsy may be linked to changes in how the brain clears waste.
Ketogenic diet therapies improve seizure reduction rates in children and adults with drug-resistant epilepsy
Ketogenic diet shows promise for people with drug-resistant epilepsy
This systematic review and meta-analysis evaluates ketogenic diet therapies for drug-resistant epilepsy across children, adolescents, and ad…
A ketogenic diet can significantly reduce seizure frequency for children, teens, and adults living with drug-resistant epilepsy.
Comprehensive intervention measures improve health literacy and self-management ability in patients with epilepsy
Better health literacy helps people manage epilepsy more effectively
This narrative review examines the factors influencing health literacy and the impact of comprehensive interventions on patient outcomes in …
Improving how patients understand their condition can lead to better self-management and higher quality of life for those living with epilep…
Perampanel provides seizure freedom for 42% of patients with brain tumor-related epilepsy
Perampanel Shows Promise for Seizures Linked to Brain Tumors
This meta-analysis of real-world clinical data evaluates perampanel for managing seizures in patients with brain tumors. The analysis found …
A review of real-world data suggests that the medication perampanel can help many patients manage seizures caused by brain tumors.
DPP-4 inhibitors may reduce drug-resistant epilepsy risk via the gut microbiota and GLP-1 axis
DPP-4 Inhibitors May Offer New Hope for Drug-Resistant Epilepsy
This systematic review explores how DPP-4 inhibitors might mitigate drug-resistant epilepsy through a hypothesized gut microbiota-SCFA-GLP-1…
New research explores how a common class of medications might protect the brain and improve gut health in patients with drug-resistant epile…
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
First case report links zonisamide to homicidal ideation in epilepsy patient
First case report links zonisamide to homicidal thoughts in an epilepsy patient
A case report and literature review describes a patient with epilepsy who developed homicidal ideation during zonisamide uptitration. Sympto…
A patient developed homicidal thoughts after taking zonisamide. This rare case highlights a serious psychiatric side effect of the drug that…
MRI-guided laser interstitial thermal therapy shows variable seizure freedom in drug-resistant epilepsy
MRI laser therapy for drug-resistant epilepsy shows wide seizure freedom rates
A systematic review of systematic reviews evaluated MRI-guided laser interstitial thermal therapy for patients with drug-resistant epilepsy.…
A review of 16 studies finds MRI-guided laser therapy can free some patients from seizures, but the success rate varies widely and safety ri…
Systematic review and meta-analysis of levetiracetam efficacy in pediatric epilepsy patients
Levetiracetam shows seizure benefits over placebo in children with epilepsy
This systematic review and meta-analysis evaluated levetiracetam (LEV) in patients 16 years or younger with epilepsy. The analysis included …
A large analysis found levetiracetam improved seizure freedom and responder rates compared to placebo in children, though it did not consist…